pioglitazone-5930 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pioglitazone-5930 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABR active BCR-related
ACACA acetyl-CoA carboxylase alpha
ADAM8 ADAM metallopeptidase domain 8
ADM adrenomedullin
AEN apoptosis enhancing nuclease
AK5 adenylate kinase 5
AKR1C2 aldo-keto reductase family 1, member C2
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARHGAP22 Rho GTPase activating protein 22
ARHGAP26 Rho GTPase activating protein 26
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP10A ATPase, class V, type 10A
BTN3A2 butyrophilin, subfamily 3, member A2
CACYBP calcyclin binding protein
CDH7 cadherin 7, type 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHKA choline kinase alpha
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIDEC cell death-inducing DFFA-like effector c
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAH3 dynein, axonemal, heavy chain 3
DSCC1 DNA replication and sister chromatid cohesion 1
DUSP2 dual specificity phosphatase 2
EDNRA endothelin receptor type A
EFNB1 ephrin-B1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELOVL6 ELOVL fatty acid elongase 6
EMP1 epithelial membrane protein 1
EPN1 epsin 1
FABP4 fatty acid binding protein 4, adipocyte
FRS3 fibroblast growth factor receptor substrate 3
FYB FYN binding protein
GFOD2 glucose-fructose oxidoreductase domain containing 2
GK glycerol kinase
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL12A interleukin 12A
IL17RB interleukin 17 receptor B
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KDM6B lysine (K)-specific demethylase 6B
KIAA1467 KIAA1467
KLF4 Kruppel-like factor 4 (gut)
LAMA4 laminin, alpha 4
LPIN1 lipin 1
LYPD3 LY6/PLAUR domain containing 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPT microtubule-associated protein tau
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1B myosin IB
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOL10 nucleolar protein 10
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPY2R neuropeptide Y receptor Y2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGFR opioid growth factor receptor
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PFDN4 prefoldin subunit 4
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLCH1 phospholipase C, eta 1
PLIN2 perilipin 2
PML promyelocytic leukemia
POTEKP POTE ankyrin domain family, member K, pseudogene
PPARD peroxisome proliferator-activated receptor delta
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKCD protein kinase C, delta
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAB33B RAB33B, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBPMS RNA binding protein with multiple splicing
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RPGRIP1L RPGRIP1-like
RRP1 ribosomal RNA processing 1
SCN9A sodium channel, voltage gated, type IX alpha subunit
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC30A1 solute carrier family 30 (zinc transporter), member 1
STK17B serine/threonine kinase 17b
SUMO1 small ubiquitin-like modifier 1
SYMPK symplekin
TLN2 talin 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPST2 tyrosylprotein sulfotransferase 2
TRIM29 tripartite motif containing 29
URI1 URI1, prefoldin-like chaperone
ZNF267 zinc finger protein 267
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AFF4 AF4/FMR2 family, member 4
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALS2CL ALS2 C-terminal like
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX4 armadillo repeat containing, X-linked 4
ARSJ arylsulfatase family, member J
ASPHD1 aspartate beta-hydroxylase domain containing 1
AURKC aurora kinase C
C11ORF80 chromosome 11 open reading frame 80
C17ORF80 chromosome 17 open reading frame 80
C1S complement component 1, s subcomponent
C22ORF29 chromosome 22 open reading frame 29
C8A complement component 8, alpha polypeptide
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CD1C CD1c molecule
CD70 CD70 molecule
CHRDL1 chordin-like 1
CLCN2 chloride channel, voltage-sensitive 2
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CTSO cathepsin O
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ETAA1 Ewing tumor-associated antigen 1
EXOSC1 exosome component 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM118A family with sequence similarity 118, member A
FBRS fibrosin
FBXO2 F-box protein 2
FZD8 frizzled class receptor 8
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRM4 glutamate receptor, metabotropic 4
GRPR gastrin-releasing peptide receptor
HDAC11 histone deacetylase 11
HIST1H2AI histone cluster 1, H2ai
HIST1H2AL histone cluster 1, H2al
HIST1H2BC histone cluster 1, H2bc
HOXB2 homeobox B2
IBSP integrin-binding sialoprotein
IL33 interleukin 33
IQCC IQ motif containing C
ISL1 ISL LIM homeobox 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD7 potassium channel tetramerization domain containing 7
KRT4 keratin 4, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LPAR4 lysophosphatidic acid receptor 4
MAGIX MAGI family member, X-linked
MANSC1 MANSC domain containing 1
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MIR622 microRNA 622
MMP13 matrix metallopeptidase 13
NABP1 nucleic acid binding protein 1
NCS1 neuronal calcium sensor 1
NDE1 nudE neurodevelopment protein 1
NDP Norrie disease (pseudoglioma)
NOL12 nucleolar protein 12
NRTN neurturin
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PARM1 prostate androgen-regulated mucin-like protein 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PDGFRL platelet-derived growth factor receptor-like
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLAU plasminogen activator, urokinase
PLD3 phospholipase D family, member 3
PLK2 polo-like kinase 2
POM121 POM121 transmembrane nucleoporin
PRB3 proline-rich protein BstNI subfamily 3
PRR14L proline rich 14-like
PRR15L proline rich 15-like
PRSS8 protease, serine, 8
RAB36 RAB36, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
REM1 RAS (RAD and GEM)-like GTP-binding 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC17A4 solute carrier family 17, member 4
SLC46A3 solute carrier family 46, member 3
SLITRK5 SLIT and NTRK-like family, member 5
SNRPN small nuclear ribonucleoprotein polypeptide N
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM180 transmembrane protein 180
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIB2 tribbles pseudokinase 2
TTC33 tetratricopeptide repeat domain 33
TXK TXK tyrosine kinase
WFDC2 WAP four-disulfide core domain 2
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB38 zinc finger and BTB domain containing 38
ZNF253 zinc finger protein 253
ZNF749 zinc finger protein 749