pioglitazone-5972 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the pioglitazone-5972 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMT aminomethyltransferase
ARL4C ADP-ribosylation factor-like 4C
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEGAIN brain-enriched guanylate kinase-associated
C14ORF79 chromosome 14 open reading frame 79
CCDC186 coiled-coil domain containing 186
CCDC9 coiled-coil domain containing 9
CCNO cyclin O
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CNN1 calponin 1, basic, smooth muscle
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL6A1 collagen, type VI, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DICER1 dicer 1, ribonuclease type III
DIXDC1 DIX domain containing 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DTNA dystrobrevin, alpha
EPHX2 epoxide hydrolase 2, cytoplasmic
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPOR erythropoietin receptor
ERP44 endoplasmic reticulum protein 44
ETNK1 ethanolamine kinase 1
EXOC7 exocyst complex component 7
FBXL5 F-box and leucine-rich repeat protein 5
FBXO11 F-box protein 11
FGF2 fibroblast growth factor 2 (basic)
FMO2 flavin containing monooxygenase 2 (non-functional)
GAMT guanidinoacetate N-methyltransferase
GPATCH2L G patch domain containing 2-like
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRB10 growth factor receptor-bound protein 10
HFE hemochromatosis
HHAT hedgehog acyltransferase
HIPK2 homeodomain interacting protein kinase 2
HIST1H2AJ histone cluster 1, H2aj
HSF4 heat shock transcription factor 4
HSPA12A heat shock 70kDa protein 12A
HTATSF1 HIV-1 Tat specific factor 1
IL12RB1 interleukin 12 receptor, beta 1
IL1RAP interleukin 1 receptor accessory protein
IL2RB interleukin 2 receptor, beta
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KRT83 keratin 83, type II
LIMCH1 LIM and calponin homology domains 1
LIN7B lin-7 homolog B (C. elegans)
LRP2 low density lipoprotein receptor-related protein 2
LRRC14 leucine rich repeat containing 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MUC3B mucin 3B, cell surface associated
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFX1 nuclear transcription factor, X-box binding 1
NMT2 N-myristoyltransferase 2
NOD1 nucleotide-binding oligomerization domain containing 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OCLM oculomedin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PARVA parvin, alpha
PCDHGB5 protocadherin gamma subfamily B, 5
PDE3B phosphodiesterase 3B, cGMP-inhibited
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITX1 paired-like homeodomain 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PVR poliovirus receptor
RAB27B RAB27B, member RAS oncogene family
RANBP3 RAN binding protein 3
RGS10 regulator of G-protein signaling 10
RGS12 regulator of G-protein signaling 12
RGS14 regulator of G-protein signaling 14
RIN3 Ras and Rab interactor 3
ROM1 retinal outer segment membrane protein 1
SCAMP1 secretory carrier membrane protein 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SH3BP2 SH3-domain binding protein 2
SIPA1 signal-induced proliferation-associated 1
SIRT3 sirtuin 3
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMC1A structural maintenance of chromosomes 1A
TAZ tafazzin
TCF25 transcription factor 25 (basic helix-loop-helix)
TDRD12 tudor domain containing 12
TPMT thiopurine S-methyltransferase
TRIM5 tripartite motif containing 5
USP12 ubiquitin specific peptidase 12
VASH2 vasohibin 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZNF304 zinc finger protein 304
ZNF37BP zinc finger protein 37B, pseudogene
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AIM2 absent in melanoma 2
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASIC4 acid sensing (proton gated) ion channel family member 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BAG4 BCL2-associated athanogene 4
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BICC1 BicC family RNA binding protein 1
BTF3P11 basic transcription factor 3 pseudogene 11
C19ORF73 chromosome 19 open reading frame 73
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CBX8 chromobox homolog 8
CCDC134 coiled-coil domain containing 134
CCDC7 coiled-coil domain containing 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD83 CD83 molecule
CLSPN claspin
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTN5 contactin 5
CPNE7 copine VII
CST4 cystatin S
CTRL chymotrypsin-like
DSPP dentin sialophosphoprotein
EGFL7 EGF-like-domain, multiple 7
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EMCN endomucin
EREG epiregulin
EXD3 exonuclease 3'-5' domain containing 3
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FOS FBJ murine osteosarcoma viral oncogene homolog
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAS2 growth arrest-specific 2
GAST gastrin
GEMIN8 gem (nuclear organelle) associated protein 8
GFAP glial fibrillary acidic protein
GGTLC1 gamma-glutamyltransferase light chain 1
GMEB1 glucocorticoid modulatory element binding protein 1
GREB1L growth regulation by estrogen in breast cancer-like
GRIP2 glutamate receptor interacting protein 2
HAMP hepcidin antimicrobial peptide
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-J major histocompatibility complex, class I, J (pseudogene)
HPR haptoglobin-related protein
HSF2BP heat shock transcription factor 2 binding protein
ITM2C integral membrane protein 2C
KIAA1456 KIAA1456
LAMP5 lysosomal-associated membrane protein family, member 5
LHX3 LIM homeobox 3
LINS lines homolog (Drosophila)
LOC729164 hCG1732469
LRP4 low density lipoprotein receptor-related protein 4
LRRTM2 leucine rich repeat transmembrane neuronal 2
MMP17 matrix metallopeptidase 17 (membrane-inserted)
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OVGP1 oviductal glycoprotein 1, 120kDa
PCBP3 poly(rC) binding protein 3
PCDHA5 protocadherin alpha 5
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
POM121 POM121 transmembrane nucleoporin
POU3F2 POU class 3 homeobox 2
PRB3 proline-rich protein BstNI subfamily 3
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRMT8 protein arginine methyltransferase 8
PRR4 proline rich 4 (lacrimal)
RAB3A RAB3A, member RAS oncogene family
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SHARPIN SHANK-associated RH domain interactor
SIX1 SIX homeobox 1
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMR3A submaxillary gland androgen regulated protein 3A
SOCS7 suppressor of cytokine signaling 7
TMEM104 transmembrane protein 104
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPAN2 tetraspanin 2
UNC13A unc-13 homolog A (C. elegans)
VGF VGF nerve growth factor inducible
WFDC2 WAP four-disulfide core domain 2
ZFHX2 zinc finger homeobox 2
ZNF423 zinc finger protein 423
ZNF639 zinc finger protein 639
ZNF76 zinc finger protein 76