pioglitazone-5977 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the pioglitazone-5977 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
AKAP7 A kinase (PRKA) anchor protein 7
AMBRA1 autophagy/beclin-1 regulator 1
ANGPTL4 angiopoietin-like 4
ANKRD55 ankyrin repeat domain 55
AQP3 aquaporin 3 (Gill blood group)
ARHGAP26 Rho GTPase activating protein 26
ATP10A ATPase, class V, type 10A
BTBD18 BTB (POZ) domain containing 18
BTN3A1 butyrophilin, subfamily 3, member A1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C14ORF1 chromosome 14 open reading frame 1
CDH7 cadherin 7, type 2
CDK18 cyclin-dependent kinase 18
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCN1 chloride channel, voltage-sensitive 1
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
DHODH dihydroorotate dehydrogenase (quinone)
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
EMC3 ER membrane protein complex subunit 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FABP4 fatty acid binding protein 4, adipocyte
FBXL7 F-box and leucine-rich repeat protein 7
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FRMD1 FERM domain containing 1
GAL galanin/GMAP prepropeptide
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
HBQ1 hemoglobin, theta 1
HCRP1 hepatocellular carcinoma-related HCRP1
HIC2 hypermethylated in cancer 2
HIGD2A HIG1 hypoxia inducible domain family, member 2A
IFFO1 intermediate filament family orphan 1
IL11 interleukin 11
IL17RA interleukin 17 receptor A
IL1B interleukin 1, beta
IQCK IQ motif containing K
JUN jun proto-oncogene
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIRREL kin of IRRE like (Drosophila)
KLF2 Kruppel-like factor 2
KRT31 keratin 31, type I
LPIN1 lipin 1
LRRN2 leucine rich repeat neuronal 2
LUZP4 leucine zipper protein 4
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MBD2 methyl-CpG binding domain protein 2
MECP2 methyl CpG binding protein 2
MFN2 mitofusin 2
MRPS12 mitochondrial ribosomal protein S12
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPFFR1 neuropeptide FF receptor 1
NRP2 neuropilin 2
NSUN6 NOP2/Sun domain family, member 6
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PCDHGB5 protocadherin gamma subfamily B, 5
PDE10A phosphodiesterase 10A
PDGFB platelet-derived growth factor beta polypeptide
PDZK1 PDZ domain containing 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLIN2 perilipin 2
PPARD peroxisome proliferator-activated receptor delta
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PVT1 Pvt1 oncogene (non-protein coding)
RHOT2 ras homolog family member T2
RIN3 Ras and Rab interactor 3
RPL10 ribosomal protein L10
RPS4Y1 ribosomal protein S4, Y-linked 1
SCN9A sodium channel, voltage gated, type IX alpha subunit
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SENP6 SUMO1/sentrin specific peptidase 6
SGK2 serum/glucocorticoid regulated kinase 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SORBS1 sorbin and SH3 domain containing 1
SQSTM1 sequestosome 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
TAT tyrosine aminotransferase
TFEB transcription factor EB
TK2 thymidine kinase 2, mitochondrial
TMEM209 transmembrane protein 209
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM29 tripartite motif containing 29
VAV2 vav 2 guanine nucleotide exchange factor
VIPR2 vasoactive intestinal peptide receptor 2
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ABI3BP ABI family, member 3 (NESH) binding protein
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRB2 adhesion G protein-coupled receptor B2
ALPK3 alpha-kinase 3
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
BMP4 bone morphogenetic protein 4
C1RL complement component 1, r subcomponent-like
C22ORF46 chromosome 22 open reading frame 46
C5ORF42 chromosome 5 open reading frame 42
CARF calcium responsive transcription factor
CCP110 centriolar coiled coil protein 110kDa
CD79A CD79a molecule, immunoglobulin-associated alpha
CERS4 ceramide synthase 4
CHM choroideremia (Rab escort protein 1)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DSCAM Down syndrome cell adhesion molecule
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC2 excision repair cross-complementation group 2
EVI2B ecotropic viral integration site 2B
F13A1 coagulation factor XIII, A1 polypeptide
FAM186A family with sequence similarity 186, member A
FBXO31 F-box protein 31
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FMO4 flavin containing monooxygenase 4
GAN gigaxonin
GAS8 growth arrest-specific 8
GDAP2 ganglioside induced differentiation associated protein 2
GLDC glycine dehydrogenase (decarboxylating)
GMEB1 glucocorticoid modulatory element binding protein 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSTCD glutathione S-transferase, C-terminal domain containing
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H4C histone cluster 1, H4c
HMHA1 histocompatibility (minor) HA-1
HOXA2 homeobox A2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGFBP1 insulin-like growth factor binding protein 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KLF15 Kruppel-like factor 15
KREMEN2 kringle containing transmembrane protein 2
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC730101 uncharacterized LOC730101
LRP2 low density lipoprotein receptor-related protein 2
LRRK1 leucine-rich repeat kinase 1
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MMP13 matrix metallopeptidase 13
MTERF4 mitochondrial transcription termination factor 4
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NEK11 NIMA-related kinase 11
NPIPB3 nuclear pore complex interacting protein family, member B3
OSMR oncostatin M receptor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI2 peptidyl arginine deiminase, type II
PCOLCE procollagen C-endopeptidase enhancer
PLK2 polo-like kinase 2
POLL polymerase (DNA directed), lambda
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRS protein tyrosine phosphatase, receptor type, S
QPCTL glutaminyl-peptide cyclotransferase-like
RGS17 regulator of G-protein signaling 17
RWDD2A RWD domain containing 2A
SCEL sciellin
SEPP1 selenoprotein P, plasma, 1
SHPK sedoheptulokinase
SHROOM2 shroom family member 2
SIX1 SIX homeobox 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SOSTDC1 sclerostin domain containing 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A3 steroid 5 alpha-reductase 3
SSBP3 single stranded DNA binding protein 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYNGR3 synaptogyrin 3
TAS2R1 taste receptor, type 2, member 1
TGFB3 transforming growth factor, beta 3
TH tyrosine hydroxylase
TMEM104 transmembrane protein 104
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TUBA3C tubulin, alpha 3c
VEZT vezatin, adherens junctions transmembrane protein
VN1R1 vomeronasal 1 receptor 1
VNN2 vanin 2
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFPM2 zinc finger protein, FOG family member 2
ZNF230 zinc finger protein 230
ZNF286A zinc finger protein 286A
ZNF446 zinc finger protein 446