pioglitazone-6893 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the pioglitazone-6893 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ADM adrenomedullin
ANGPTL4 angiopoietin-like 4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP3 aquaporin 3 (Gill blood group)
ARID1A AT rich interactive domain 1A (SWI-like)
ARMC6 armadillo repeat containing 6
ATP10A ATPase, class V, type 10A
BTN3A1 butyrophilin, subfamily 3, member A1
CCDC57 coiled-coil domain containing 57
CCNA1 cyclin A1
CDC5L cell division cycle 5-like
CDH7 cadherin 7, type 2
CDK13 cyclin-dependent kinase 13
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYBA2 crystallin, beta A2
CSF1 colony stimulating factor 1 (macrophage)
DLX2 distal-less homeobox 2
DSC2 desmocollin 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL4 ELOVL fatty acid elongase 4
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ETNK1 ethanolamine kinase 1
FABP4 fatty acid binding protein 4, adipocyte
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FYB FYN binding protein
FZD5 frizzled class receptor 5
GK glycerol kinase
GLB1L2 galactosidase, beta 1-like 2
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRSF1 G-rich RNA sequence binding factor 1
IL1B interleukin 1, beta
INO80B INO80 complex subunit B
IRS2 insulin receptor substrate 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITK IL2-inducible T-cell kinase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LAMA4 laminin, alpha 4
LPAR2 lysophosphatidic acid receptor 2
LPIN1 lipin 1
LRRN2 leucine rich repeat neuronal 2
MFSD6 major facilitator superfamily domain containing 6
MTAP methylthioadenosine phosphorylase
MTM1 myotubularin 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPY2R neuropeptide Y receptor Y2
NUDCD3 NudC domain containing 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIDD1 p53-induced death domain protein 1
PLIN2 perilipin 2
PLK3 polo-like kinase 3
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCD protein kinase C, delta
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAD51D RAD51 paralog D
REC8 REC8 meiotic recombination protein
RGCC regulator of cell cycle
RGS14 regulator of G-protein signaling 14
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RPAIN RPA interacting protein
SATB2 SATB homeobox 2
SCAMP1 secretory carrier membrane protein 1
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDC2 syndecan 2
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIK1 salt-inducible kinase 1
SIRT3 sirtuin 3
SIX2 SIX homeobox 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SRPK2 SRSF protein kinase 2
SSX1 synovial sarcoma, X breakpoint 1
STARD5 StAR-related lipid transfer (START) domain containing 5
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TFDP3 transcription factor Dp family, member 3
TGFA transforming growth factor, alpha
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM1 tropomyosin 1 (alpha)
TWSG1 twisted gastrulation BMP signaling modulator 1
UBE4B ubiquitination factor E4B
WAS Wiskott-Aldrich syndrome
WDFY3 WD repeat and FYVE domain containing 3
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACP2 acid phosphatase 2, lysosomal
ADAM29 ADAM metallopeptidase domain 29
ADGRB2 adhesion G protein-coupled receptor B2
AIM2 absent in melanoma 2
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOH apolipoprotein H (beta-2-glycoprotein I)
ARPIN actin-related protein 2/3 complex inhibitor
ARSA arylsulfatase A
ASB8 ankyrin repeat and SOCS box containing 8
AURKC aurora kinase C
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBC3 BCL2 binding component 3
BCAS3 breast carcinoma amplified sequence 3
BEND5 BEN domain containing 5
BMP4 bone morphogenetic protein 4
C1R complement component 1, r subcomponent
C3 complement component 3
CCDC94 coiled-coil domain containing 94
CCR9 chemokine (C-C motif) receptor 9
CD82 CD82 molecule
CEL carboxyl ester lipase
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CINP cyclin-dependent kinase 2 interacting protein
CLIC3 chloride intracellular channel 3
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPNE7 copine VII
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DLL3 delta-like 3 (Drosophila)
EGFL7 EGF-like-domain, multiple 7
EPN1 epsin 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FRS2 fibroblast growth factor receptor substrate 2
FZD8 frizzled class receptor 8
GRPR gastrin-releasing peptide receptor
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
IL17RB interleukin 17 receptor B
ITGA8 integrin, alpha 8
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0513 KIAA0513
KIFC1 kinesin family member C1
KRT15 keratin 15, type I
LMNB1 lamin B1
LPAR6 lysophosphatidic acid receptor 6
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MOXD1 monooxygenase, DBH-like 1
MRPL52 mitochondrial ribosomal protein L52
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
NSUN6 NOP2/Sun domain family, member 6
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P3H2 prolyl 3-hydroxylase 2
PCDHGB5 protocadherin gamma subfamily B, 5
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PIP prolactin-induced protein
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK2 polo-like kinase 2
PODXL2 podocalyxin-like 2
PSENEN presenilin enhancer gamma secretase subunit
PTGFR prostaglandin F receptor (FP)
PTPRH protein tyrosine phosphatase, receptor type, H
RAB17 RAB17, member RAS oncogene family
RBM23 RNA binding motif protein 23
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUNX1-IT1 RUNX1 intronic transcript 1
SCEL sciellin
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC46A3 solute carrier family 46, member 3
SMA4 glucuronidase, beta pseudogene
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB3 transforming growth factor, beta 3
THBS3 thrombospondin 3
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TLR2 toll-like receptor 2
TMEM156 transmembrane protein 156
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNS2 tensin 2
TTC31 tetratricopeptide repeat domain 31
UNC119 unc-119 homolog (C. elegans)
ZFHX2 zinc finger homeobox 2
ZNF32 zinc finger protein 32
ZNF41 zinc finger protein 41
ZNF74 zinc finger protein 74
ZNF76 zinc finger protein 76
ZNF767P zinc finger family member 767, pseudogene
ZNF862 zinc finger protein 862