pioglitazone-6898 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the pioglitazone-6898 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATM ATM serine/threonine kinase
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BTBD7 BTB (POZ) domain containing 7
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC85C coiled-coil domain containing 85C
CCHCR1 coiled-coil alpha-helical rod protein 1
CDH18 cadherin 18, type 2
CENPF centromere protein F, 350/400kDa
CES3 carboxylesterase 3
CHMP1B charged multivesicular body protein 1B
COPS2 COP9 signalosome subunit 2
CREM cAMP responsive element modulator
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
E2F4 E2F transcription factor 4, p107/p130-binding
EML1 echinoderm microtubule associated protein like 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO11 F-box protein 11
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FXR2 fragile X mental retardation, autosomal homolog 2
HEATR3 HEAT repeat containing 3
HFE hemochromatosis
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFNAR2 interferon (alpha, beta and omega) receptor 2
ING1 inhibitor of growth family, member 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF2 interferon regulatory factor 2
KHK ketohexokinase (fructokinase)
KIAA0895 KIAA0895
KPNA6 karyopherin alpha 6 (importin alpha 7)
KRT86 keratin 86, type II
LAMP1 lysosomal-associated membrane protein 1
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRRC14 leucine rich repeat containing 14
LRRC23 leucine rich repeat containing 23
LRRC41 leucine rich repeat containing 41
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP2K3 mitogen-activated protein kinase kinase 3
MIIP migration and invasion inhibitory protein
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTF2 metal response element binding transcription factor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFX1 nuclear transcription factor, X-box binding 1
NFYA nuclear transcription factor Y, alpha
NUMA1 nuclear mitotic apparatus protein 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PGK1 phosphoglycerate kinase 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PVR poliovirus receptor
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RAD51B RAD51 paralog B
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
REPS1 RALBP1 associated Eps domain containing 1
RHBDD3 rhomboid domain containing 3
RPAP1 RNA polymerase II associated protein 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SH2B1 SH2B adaptor protein 1
SIK3 SIK family kinase 3
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOCS2 suppressor of cytokine signaling 2
SOCS5 suppressor of cytokine signaling 5
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRY2 sprouty homolog 2 (Drosophila)
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX16 syntaxin 16
SYNRG synergin, gamma
TBC1D4 TBC1 domain family, member 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TRIM14 tripartite motif containing 14
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TTC38 tetratricopeptide repeat domain 38
UBXN6 UBX domain protein 6
VAX2 ventral anterior homeobox 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VGF VGF nerve growth factor inducible
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR61 WD repeat domain 61
WNK1 WNK lysine deficient protein kinase 1
WWOX WW domain containing oxidoreductase
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZBTB7A zinc finger and BTB domain containing 7A
ZNF365 zinc finger protein 365
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APH1A APH1A gamma secretase subunit
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BATF basic leucine zipper transcription factor, ATF-like
BAX BCL2-associated X protein
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL9 B-cell CLL/lymphoma 9
C10ORF88 chromosome 10 open reading frame 88
C2ORF44 chromosome 2 open reading frame 44
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK3 cyclin-dependent kinase 3
CENPO centromere protein O
CFAP44 cilia and flagella associated protein 44
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
DEAF1 DEAF1 transcription factor
DGAT1 diacylglycerol O-acyltransferase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUSP2 dual specificity phosphatase 2
EPHB6 EPH receptor B6
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV6 ets variant 6
FGL1 fibrinogen-like 1
FRMPD1 FERM and PDZ domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
GDAP1 ganglioside induced differentiation associated protein 1
GPR19 G protein-coupled receptor 19
GPR68 G protein-coupled receptor 68
GRM4 glutamate receptor, metabotropic 4
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIRA histone cell cycle regulator
HIST1H4D histone cluster 1, H4d
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HYAL1 hyaluronoglucosaminidase 1
IL4R interleukin 4 receptor
INE1 inactivation escape 1 (non-protein coding)
IQSEC2 IQ motif and Sec7 domain 2
IRF6 interferon regulatory factor 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
LHX1 LIM homeobox 1
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
MCOLN1 mucolipin 1
MCOLN3 mucolipin 3
MED9 mediator complex subunit 9
MGC12488
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MTA2 metastasis associated 1 family, member 2
MTCL1 microtubule crosslinking factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVP major vault protein
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRTN neurturin
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
P3H1 prolyl 3-hydroxylase 1
PADI1 peptidyl arginine deiminase, type I
PCDHGB5 protocadherin gamma subfamily B, 5
PEX26 peroxisomal biogenesis factor 26
PGP phosphoglycolate phosphatase
PLCD1 phospholipase C, delta 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PPT2 palmitoyl-protein thioesterase 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTPRM protein tyrosine phosphatase, receptor type, M
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB35 RAB35, member RAS oncogene family
RIN2 Ras and Rab interactor 2
RNF121 ring finger protein 121
RNF39 ring finger protein 39
SCNN1B sodium channel, non voltage gated 1 beta subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SETD8 SET domain containing (lysine methyltransferase) 8
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SND1-IT1 SND1 intronic transcript 1
SPON2 spondin 2, extracellular matrix protein
SRD5A3 steroid 5 alpha-reductase 3
STARD5 StAR-related lipid transfer (START) domain containing 5
TGFB3 transforming growth factor, beta 3
TIGD6 tigger transposable element derived 6
TRIM25 tripartite motif containing 25
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TUBB1 tubulin, beta 1 class VI
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBTD1 ubiquitin domain containing 1
VIM vimentin
WDR25 WD repeat domain 25
XYLT1 xylosyltransferase I
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF205 zinc finger protein 205