pioglitazone-7083 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the pioglitazone-7083 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADRBK2 adrenergic, beta, receptor kinase 2
ALMS1 Alstrom syndrome protein 1
ARFRP1 ADP-ribosylation factor related protein 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BMP7 bone morphogenetic protein 7
BRAP BRCA1 associated protein
C21ORF2 chromosome 21 open reading frame 2
C21ORF91 chromosome 21 open reading frame 91
C2ORF54 chromosome 2 open reading frame 54
CABIN1 calcineurin binding protein 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCNE1 cyclin E1
COPA coatomer protein complex, subunit alpha
CRAT carnitine O-acetyltransferase
CTBS chitobiase, di-N-acetyl-
CTSF cathepsin F
CUL7 cullin 7
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DLX2 distal-less homeobox 2
DND1 DND microRNA-mediated repression inhibitor 1
EFCAB2 EF-hand calcium binding domain 2
EFNB3 ephrin-B3
ELF4 E74-like factor 4 (ets domain transcription factor)
FAM155B family with sequence similarity 155, member B
FAM184A family with sequence similarity 184, member A
FCMR Fc fragment of IgM receptor
FGFR1 fibroblast growth factor receptor 1
FLJ10038 uncharacterized protein FLJ10038
FLT4 fms-related tyrosine kinase 4
GLIPR1 GLI pathogenesis-related 1
GP2 glycoprotein 2 (zymogen granule membrane)
GPER1 G protein-coupled estrogen receptor 1
GPR107 G protein-coupled receptor 107
GPR137 G protein-coupled receptor 137
GTDC1 glycosyltransferase-like domain containing 1
GYG2 glycogenin 2
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HK2 hexokinase 2
HYAL2 hyaluronoglucosaminidase 2
ICAM1 intercellular adhesion molecule 1
INADL InaD-like (Drosophila)
INF2 inverted formin, FH2 and WH2 domain containing
INPP5K inositol polyphosphate-5-phosphatase K
IRF5 interferon regulatory factor 5
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KREMEN2 kringle containing transmembrane protein 2
LMF2 lipase maturation factor 2
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAGOH2P mago-nashi homolog 2, pseudogene
MAPK11 mitogen-activated protein kinase 11
MED28 mediator complex subunit 28
MMP9 matrix metallopeptidase 9
MYOF myoferlin
NECAB3 N-terminal EF-hand calcium binding protein 3
OASL 2'-5'-oligoadenylate synthetase-like
PCGF2 polycomb group ring finger 2
PDCD2 programmed cell death 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRDX2 peroxiredoxin 2
PTK6 protein tyrosine kinase 6
PTTG3P pituitary tumor-transforming 3, pseudogene
RABGAP1 RAB GTPase activating protein 1
RANGRF RAN guanine nucleotide release factor
RBM10 RNA binding motif protein 10
RECQL5 RecQ protein-like 5
RGS10 regulator of G-protein signaling 10
RHBDD3 rhomboid domain containing 3
RPL23AP32 ribosomal protein L23a pseudogene 32
RPLP2 ribosomal protein, large, P2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOWAHC sosondowah ankyrin repeat domain family member C
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT5B signal transducer and activator of transcription 5B
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TBCD tubulin folding cofactor D
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPAN9 tetraspanin 9
UPP1 uridine phosphorylase 1
WDTC1 WD and tetratricopeptide repeats 1
WRAP53 WD repeat containing, antisense to TP53
WSB1 WD repeat and SOCS box containing 1
ZC3H3 zinc finger CCCH-type containing 3
ZER1 zyg-11 related, cell cycle regulator
ZFR zinc finger RNA binding protein

decreased expression

Symbol Name
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ARMC4 armadillo repeat containing 4
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BSG basigin (Ok blood group)
C1ORF56 chromosome 1 open reading frame 56
C7ORF43 chromosome 7 open reading frame 43
CAPN1 calpain 1, (mu/I) large subunit
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD82 CD82 molecule
CDK3 cyclin-dependent kinase 3
CHST10 carbohydrate sulfotransferase 10
COLGALT1 collagen beta(1-O)galactosyltransferase 1
COMMD10 COMM domain containing 10
COPS7B COP9 signalosome subunit 7B
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYBA cytochrome b-245, alpha polypeptide
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDA1 DET1 and DDB1 associated 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EAF2 ELL associated factor 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXOC5 exocyst complex component 5
FAM63A family with sequence similarity 63, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HOXC8 homeobox C8
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IP6K1 inositol hexakisphosphate kinase 1
IRAK4 interleukin-1 receptor-associated kinase 4
IREB2 iron-responsive element binding protein 2
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KDM7A lysine (K)-specific demethylase 7A
KLHL25 kelch-like family member 25
KRT15 keratin 15, type I
LIG4 ligase IV, DNA, ATP-dependent
LPXN leupaxin
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MPDU1 mannose-P-dolichol utilization defect 1
MYH9 myosin, heavy chain 9, non-muscle
NMD3 NMD3 ribosome export adaptor
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRSN2 neurensin 2
NUBP2 nucleotide binding protein 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB3 protocadherin beta 3
PGD phosphogluconate dehydrogenase
PLD3 phospholipase D family, member 3
PRICKLE3 prickle homolog 3 (Drosophila)
PSENEN presenilin enhancer gamma secretase subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
RAB23 RAB23, member RAS oncogene family
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF146 ring finger protein 146
S100A4 S100 calcium binding protein A4
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERTAD3 SERTA domain containing 3
SGPP1 sphingosine-1-phosphate phosphatase 1
SH2D4A SH2 domain containing 4A
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A40 solute carrier family 25, member 40
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STK16 serine/threonine kinase 16
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN2 tectonic family member 2
TESC tescalcin
TMEM230 transmembrane protein 230
TMEM38B transmembrane protein 38B
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRABD TraB domain containing
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN1 tetraspanin 1
UBE2M ubiquitin-conjugating enzyme E2M
WDR91 WD repeat domain 91
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YIPF5 Yip1 domain family, member 5
ZMAT5 zinc finger, matrin-type 5
ZNF227 zinc finger protein 227
ZNF253 zinc finger protein 253
ZNF574 zinc finger protein 574
ZNF665 zinc finger protein 665