pioglitazone-7506 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the pioglitazone-7506 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATAT1 alpha tubulin acetyltransferase 1
BCAN brevican
BMP1 bone morphogenetic protein 1
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C2ORF27A chromosome 2 open reading frame 27A
C5 complement component 5
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CNTFR ciliary neurotrophic factor receptor
COL6A1 collagen, type VI, alpha 1
COPZ2 coatomer protein complex, subunit zeta 2
CSF1R colony stimulating factor 1 receptor
CUL7 cullin 7
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DMPK dystrophia myotonica-protein kinase
DNAH3 dynein, axonemal, heavy chain 3
DTNA dystrobrevin, alpha
EHD2 EH-domain containing 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM155A family with sequence similarity 155, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GAS6 growth arrest-specific 6
GLRX3 glutaredoxin 3
GLS2 glutaminase 2 (liver, mitochondrial)
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GP6 glycoprotein VI (platelet)
GRB10 growth factor receptor-bound protein 10
GTF2I general transcription factor IIi
HAUS5 HAUS augmin-like complex, subunit 5
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HPS1 Hermansky-Pudlak syndrome 1
IL17RB interleukin 17 receptor B
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INE1 inactivation escape 1 (non-protein coding)
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRS2 insulin receptor substrate 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF1A kinesin family member 1A
MAP2K5 mitogen-activated protein kinase kinase 5
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MITF microphthalmia-associated transcription factor
MOCS1 molybdenum cofactor synthesis 1
MRC2 mannose receptor, C type 2
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NUP62CL nucleoporin 62kDa C-terminal like
OR7A10 olfactory receptor, family 7, subfamily A, member 10
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PEX7 peroxisomal biogenesis factor 7
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLXNA3 plexin A3
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTTG3P pituitary tumor-transforming 3, pseudogene
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
RHOQ ras homolog family member Q
RNF122 ring finger protein 122
RNF219 ring finger protein 219
RPGR retinitis pigmentosa GTPase regulator
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS28 ribosomal protein S28
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMAD4 SMAD family member 4
SMIM14 small integral membrane protein 14
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SOCS5 suppressor of cytokine signaling 5
SOX9 SRY (sex determining region Y)-box 9
STMN1 stathmin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TADA2A transcriptional adaptor 2A
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TCTN2 tectonic family member 2
TMEM231 transmembrane protein 231
TMEM63A transmembrane protein 63A
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
WAS Wiskott-Aldrich syndrome
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF174 zinc finger protein 174
ZNF442 zinc finger protein 442
ZNF675 zinc finger protein 675
ZNF696 zinc finger protein 696
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ADAM18 ADAM metallopeptidase domain 18
ADAP2 ArfGAP with dual PH domains 2
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMH anti-Mullerian hormone
ANP32A-IT1 ANP32A intronic transcript 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASIC3 acid sensing (proton gated) ion channel 3
ATG7 autophagy related 7
ATXN2 ataxin 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BST1 bone marrow stromal cell antigen 1
CALCB calcitonin-related polypeptide beta
CAMK1 calcium/calmodulin-dependent protein kinase I
CARF calcium responsive transcription factor
CCNL2 cyclin L2
CCP110 centriolar coiled coil protein 110kDa
CDK3 cyclin-dependent kinase 3
CDKL3 cyclin-dependent kinase-like 3
CHRM3 cholinergic receptor, muscarinic 3
CLCN2 chloride channel, voltage-sensitive 2
CLDN15 claudin 15
CRYGD crystallin, gamma D
DAGLA diacylglycerol lipase, alpha
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF4 DDB1 and CUL4 associated factor 4
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DSCAM Down syndrome cell adhesion molecule
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPN1 epsin 1
FAM188A family with sequence similarity 188, member A
FBXO22 F-box protein 22
FER fer (fps/fes related) tyrosine kinase
GAN gigaxonin
GFI1 growth factor independent 1 transcription repressor
GLB1L2 galactosidase, beta 1-like 2
GLI3 GLI family zinc finger 3
HDAC7 histone deacetylase 7
HIST1H2BJ histone cluster 1, H2bj
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IMPACT impact RWD domain protein
IQSEC2 IQ motif and Sec7 domain 2
ITPKA inositol-trisphosphate 3-kinase A
KIF13B kinesin family member 13B
KRT75 keratin 75, type II
KRT83 keratin 83, type II
LAMA3 laminin, alpha 3
LIME1 Lck interacting transmembrane adaptor 1
LPAR3 lysophosphatidic acid receptor 3
LRP6 low density lipoprotein receptor-related protein 6
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTFL1 leucine zipper transcription factor-like 1
MT1HL1 metallothionein 1H-like 1
MXRA8 matrix-remodelling associated 8
MYO1F myosin IF
NPHP1 nephronophthisis 1 (juvenile)
ONECUT2 one cut homeobox 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OVOL1 ovo-like zinc finger 1
PCDHB3 protocadherin beta 3
PCDHGA9 protocadherin gamma subfamily A, 9
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
POTEKP POTE ankyrin domain family, member K, pseudogene
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3D RAB3D, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
S100A9 S100 calcium binding protein A9
SCAI suppressor of cancer cell invasion
SCARA3 scavenger receptor class A, member 3
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLN sarcolipin
SND1-IT1 SND1 intronic transcript 1
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SPEG SPEG complex locus
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TDRD1 tudor domain containing 1
TMC7 transmembrane channel-like 7
TMEM104 transmembrane protein 104
TMEM212 transmembrane protein 212
TMUB2 transmembrane and ubiquitin-like domain containing 2
TTC17 tetratricopeptide repeat domain 17
TUBA4B tubulin, alpha 4b
UPP1 uridine phosphorylase 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VIPR1 vasoactive intestinal peptide receptor 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFHX2 zinc finger homeobox 2
ZIC4 Zic family member 4
ZNF155 zinc finger protein 155
ZNF35 zinc finger protein 35
ZNF365 zinc finger protein 365
ZNF428 zinc finger protein 428
ZNF471 zinc finger protein 471
ZNF573 zinc finger protein 573
ZNF665 zinc finger protein 665
ZNF816 zinc finger protein 816