pioglitazone-7523 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the pioglitazone-7523 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACOT11 acyl-CoA thioesterase 11
AQP3 aquaporin 3 (Gill blood group)
ARHGAP1 Rho GTPase activating protein 1
ARHGAP33 Rho GTPase activating protein 33
ARL4C ADP-ribosylation factor-like 4C
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP9A ATPase, class II, type 9A
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA4 carbonic anhydrase IV
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCNK cyclin K
CEP290 centrosomal protein 290kDa
CLCN2 chloride channel, voltage-sensitive 2
COX11 COX11 cytochrome c oxidase copper chaperone
CTAGE9 CTAGE family, member 9
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL3 cullin 3
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBN1 drebrin 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGKE diacylglycerol kinase, epsilon 64kDa
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DST dystonin
DVL2 dishevelled segment polarity protein 2
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EVA1B eva-1 homolog B (C. elegans)
FAM212B family with sequence similarity 212, member B
FSCN1 fascin actin-bundling protein 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HFE hemochromatosis
HMHA1 histocompatibility (minor) HA-1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSF4 heat shock transcription factor 4
IDS iduronate 2-sulfatase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KMT2A lysine (K)-specific methyltransferase 2A
LHX1 LIM homeobox 1
LIN7A lin-7 homolog A (C. elegans)
LOC157562 uncharacterized LOC157562
LRRC23 leucine rich repeat containing 23
LRRC61 leucine rich repeat containing 61
MED6 mediator complex subunit 6
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MVP major vault protein
NAIP NLR family, apoptosis inhibitory protein
PAIP2B poly(A) binding protein interacting protein 2B
PCDHA5 protocadherin alpha 5
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PHF20 PHD finger protein 20
PIDD1 p53-induced death domain protein 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PKP2 plakophilin 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
RAD52 RAD52 homolog (S. cerevisiae)
RASAL1 RAS protein activator like 1 (GAP1 like)
RIMS2 regulating synaptic membrane exocytosis 2
RNASEH2B ribonuclease H2, subunit B
RNF170 ring finger protein 170
ROM1 retinal outer segment membrane protein 1
RPL35A ribosomal protein L35a
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
SAFB2 scaffold attachment factor B2
SATB2 SATB homeobox 2
SCAMP1 secretory carrier membrane protein 1
SCAND2P SCAN domain containing 2 pseudogene
SGSM2 small G protein signaling modulator 2
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SMAD1 SMAD family member 1
SP1 Sp1 transcription factor
SP100 SP100 nuclear antigen
SPHK2 sphingosine kinase 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
ST20 suppressor of tumorigenicity 20
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCP11L1 t-complex 11, testis-specific-like 1
TMSB4Y thymosin beta 4, Y-linked
TOM1 target of myb1 (chicken)
TREX1 three prime repair exonuclease 1
TSC22D4 TSC22 domain family, member 4
USP27X ubiquitin specific peptidase 27, X-linked
WDFY3 WD repeat and FYVE domain containing 3
YPEL1 yippee-like 1 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF180 zinc finger protein 180
ZNF34 zinc finger protein 34
ZNF444 zinc finger protein 444
ZNF589 zinc finger protein 589
ZNF665 zinc finger protein 665
ZNF783 zinc finger family member 783
ZNF8 zinc finger protein 8

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALS2CL ALS2 C-terminal like
AMPD1 adenosine monophosphate deaminase 1
ANPEP alanyl (membrane) aminopeptidase
ANXA2P3 annexin A2 pseudogene 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BTNL3 butyrophilin-like 3
C10ORF95 chromosome 10 open reading frame 95
C11ORF30 chromosome 11 open reading frame 30
C1QB complement component 1, q subcomponent, B chain
C9 complement component 9
CAMK4 calcium/calmodulin-dependent protein kinase IV
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC71 coiled-coil domain containing 71
CCL17 chemokine (C-C motif) ligand 17
CEP295 centrosomal protein 295kDa
CFAP69 cilia and flagella associated protein 69
CHML choroideremia-like (Rab escort protein 2)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLDN14 claudin 14
CLDN15 claudin 15
DCAF17 DDB1 and CUL4 associated factor 17
DPY19L1P1 DPY19L1 pseudogene 1
DUSP26 dual specificity phosphatase 26 (putative)
DYSF dysferlin
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM110B family with sequence similarity 110, member B
FANCC Fanconi anemia, complementation group C
FBXO22 F-box protein 22
FOXF2 forkhead box F2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GATA4 GATA binding protein 4
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GSTP1 glutathione S-transferase pi 1
HIST1H1B histone cluster 1, H1b
HIST1H2AE histone cluster 1, H2ae
HIST1H4A histone cluster 1, H4a
IRGC immunity-related GTPase family, cinema
IRS2 insulin receptor substrate 2
ITGA8 integrin, alpha 8
ITM2C integral membrane protein 2C
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LARP6 La ribonucleoprotein domain family, member 6
LINC00597 long intergenic non-protein coding RNA 597
LMTK2 lemur tyrosine kinase 2
LOC100131510 uncharacterized LOC100131510
LRRC20 leucine rich repeat containing 20
LY6D lymphocyte antigen 6 complex, locus D
MBTPS2 membrane-bound transcription factor peptidase, site 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MMRN2 multimerin 2
MTERF4 mitochondrial transcription termination factor 4
MXD3 MAX dimerization protein 3
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NDRG1 N-myc downstream regulated 1
NNAT neuronatin
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR2H1 olfactory receptor, family 2, subfamily H, member 1
PCDH12 protocadherin 12
PITX2 paired-like homeodomain 2
PLTP phospholipid transfer protein
PSAT1 phosphoserine aminotransferase 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
SAA3P serum amyloid A3 pseudogene
SETD1A SET domain containing 1A
SFTPD surfactant protein D
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SPARCL1 SPARC-like 1 (hevin)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPTBN2 spectrin, beta, non-erythrocytic 2
ST5 suppression of tumorigenicity 5
STAB2 stabilin 2
SYNDIG1 synapse differentiation inducing 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM254 transmembrane protein 254
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TSGA10 testis specific, 10
TTC30A tetratricopeptide repeat domain 30A
UCN urocortin
VEGFC vascular endothelial growth factor C
WDR25 WD repeat domain 25
WDR33 WD repeat domain 33
WDR62 WD repeat domain 62
WLS wntless Wnt ligand secretion mediator
ZNF211 zinc finger protein 211
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZNF329 zinc finger protein 329
ZNF816 zinc finger protein 816