pioglitazone Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. (Chemical Entities of Biological Interest Ontology, CHEBI_8228)
External Link http://ctdbase.org/detail.go?type=chem&acc=C060836
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Genes

78 genes/proteins interacting with the chemical pioglitazone from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ACE angiotensin I converting enzyme
ACTA2 actin, alpha 2, smooth muscle, aorta
ADIPOQ adiponectin, C1Q and collagen domain containing
AGTR2 angiotensin II receptor, type 2
ANGPT2 angiopoietin 2
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APP amyloid beta (A4) precursor protein
BACE1 beta-site APP-cleaving enzyme 1
BSG basigin (Ok blood group)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL11 chemokine (C-C motif) ligand 11
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCND3 cyclin D3
CCNE1 cyclin E1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DIO2 deiodinase, iodothyronine, type II
DIO3 deiodinase, iodothyronine, type III
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSTA2 glutathione S-transferase alpha 2
GSTP1 glutathione S-transferase pi 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
IFNG interferon, gamma
IL13 interleukin 13
IL1B interleukin 1, beta
IL4 interleukin 4
IL5 interleukin 5
ITLN1 intelectin 1 (galactofuranose binding)
LDLR low density lipoprotein receptor
LEP leptin
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOS2 nitric oxide synthase 2, inducible
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR1H3 nuclear receptor subfamily 1, group H, member 3
PCSK9 proprotein convertase subtilisin/kexin type 9
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RXRA retinoid X receptor, alpha
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SOD1 superoxide dismutase 1, soluble
SPP1 secreted phosphoprotein 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TNF tumor necrosis factor
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A