pipemidic acid-6470 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the pipemidic acid-6470 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ABHD6 abhydrolase domain containing 6
ADAM22 ADAM metallopeptidase domain 22
ADCY6 adenylate cyclase 6
ADGRE2 adhesion G protein-coupled receptor E2
ALOX5 arachidonate 5-lipoxygenase
ANXA2P3 annexin A2 pseudogene 3
ATN1 atrophin 1
BEGAIN brain-enriched guanylate kinase-associated
C5ORF42 chromosome 5 open reading frame 42
CD44 CD44 molecule (Indian blood group)
CEP112 centrosomal protein 112kDa
CLGN calmegin
CLTC clathrin, heavy chain (Hc)
COL14A1 collagen, type XIV, alpha 1
COL4A2 collagen, type IV, alpha 2
COMMD4 COMM domain containing 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYM crystallin, mu
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DENND5B DENN/MADD domain containing 5B
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
EDNRB endothelin receptor type B
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EML2 echinoderm microtubule associated protein like 2
EPHB2 EPH receptor B2
EPX eosinophil peroxidase
EPYC epiphycan
FOXG1 forkhead box G1
GAMT guanidinoacetate N-methyltransferase
GFER growth factor, augmenter of liver regeneration
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GIMAP5 GTPase, IMAP family member 5
GJA4 gap junction protein, alpha 4, 37kDa
GPR21 G protein-coupled receptor 21
HAP1 huntingtin-associated protein 1
HIST1H2BL histone cluster 1, H2bl
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNF1B HNF1 homeobox B
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
ICOS inducible T-cell co-stimulator
IGHD immunoglobulin heavy constant delta
IL5RA interleukin 5 receptor, alpha
IRF4 interferon regulatory factor 4
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT16 keratin 16, type I
LTBP2 latent transforming growth factor beta binding protein 2
MBD1 methyl-CpG binding domain protein 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MSC musculin
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NF1 neurofibromin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OASL 2'-5'-oligoadenylate synthetase-like
PACRG PARK2 co-regulated
PCDHB3 protocadherin beta 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITX1 paired-like homeodomain 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PROX1 prospero homeobox 1
PSG3 pregnancy specific beta-1-glycoprotein 3
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
REC8 REC8 meiotic recombination protein
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCAPER S-phase cyclin A-associated protein in the ER
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SH2D3A SH2 domain containing 3A
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRCAP Snf2-related CREBBP activator protein
TACSTD2 tumor-associated calcium signal transducer 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRIM21 tripartite motif containing 21
TRIM29 tripartite motif containing 29
TTC38 tetratricopeptide repeat domain 38
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZNF197 zinc finger protein 197
ZNF551 zinc finger protein 551
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ADTRP androgen-dependent TFPI-regulating protein
ALOX15 arachidonate 15-lipoxygenase
ALS2CL ALS2 C-terminal like
AMH anti-Mullerian hormone
AMPH amphiphysin
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATAD5 ATPase family, AAA domain containing 5
C10ORF95 chromosome 10 open reading frame 95
C17ORF70 chromosome 17 open reading frame 70
C7ORF43 chromosome 7 open reading frame 43
C7ORF69 chromosome 7 open reading frame 69
CDADC1 cytidine and dCMP deaminase domain containing 1
CLCA1 chloride channel accessory 1
CLDN17 claudin 17
CRABP1 cellular retinoic acid binding protein 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOK5 docking protein 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO31 F-box protein 31
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPC3 glypican 3
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AK histone cluster 1, H2ak
HOXB2 homeobox B2
HOXC8 homeobox C8
IL12RB1 interleukin 12 receptor, beta 1
INPP1 inositol polyphosphate-1-phosphatase
IPO8 importin 8
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRT13 keratin 13, type I
LAX1 lymphocyte transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100131532 uncharacterized LOC100131532
LOC729164 hCG1732469
LRP5L low density lipoprotein receptor-related protein 5-like
LZTS3 leucine zipper, putative tumor suppressor family member 3
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MOSPD3 motile sperm domain containing 3
MVP major vault protein
NELL2 NEL-like 2 (chicken)
NPTX1 neuronal pentraxin I
NRSN2 neurensin 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NXPH4 neurexophilin 4
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
PRDM14 PR domain containing 14
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PROL1 proline rich, lacrimal 1
PRSS16 protease, serine, 16 (thymus)
RIBC2 RIB43A domain with coiled-coils 2
RNF208 ring finger protein 208
RPAP1 RNA polymerase II associated protein 1
RPGR retinitis pigmentosa GTPase regulator
RPL23AP32 ribosomal protein L23a pseudogene 32
SARS2 seryl-tRNA synthetase 2, mitochondrial
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC17A2 solute carrier family 17, member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SREK1IP1 SREK1-interacting protein 1
SRPX sushi-repeat containing protein, X-linked
STARD13 StAR-related lipid transfer (START) domain containing 13
STX1A syntaxin 1A (brain)
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUSD4 sushi domain containing 4
SYBU syntabulin (syntaxin-interacting)
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TCTN1 tectonic family member 1
THBS3 thrombospondin 3
TMCC2 transmembrane and coiled-coil domain family 2
TMEM19 transmembrane protein 19
TMEM212 transmembrane protein 212
TPCN1 two pore segment channel 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTLL1 tubulin tyrosine ligase-like family member 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFB vascular endothelial growth factor B
VPS9D1 VPS9 domain containing 1
XDH xanthine dehydrogenase
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF16 zinc finger protein 16
ZNF253 zinc finger protein 253
ZNF324 zinc finger protein 324
ZNF37BP zinc finger protein 37B, pseudogene
Funding