piperlongumine-2757 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the piperlongumine-2757 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK2 aarF domain containing kinase 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AVIL advillin
CCDC71 coiled-coil domain containing 71
CDKL3 cyclin-dependent kinase-like 3
CDKN2AIP CDKN2A interacting protein
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COPE coatomer protein complex, subunit epsilon
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF5 eukaryotic translation initiation factor 5
ELSPBP1 epididymal sperm binding protein 1
ERO1LB ERO1-like beta (S. cerevisiae)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FAM46C family with sequence similarity 46, member C
FAM53C family with sequence similarity 53, member C
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GIF gastric intrinsic factor (vitamin B synthesis)
GLP1R glucagon-like peptide 1 receptor
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HBS1L HBS1-like translational GTPase
HCG4B HLA complex group 4B (non-protein coding)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AK histone cluster 1, H2ak
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4E histone cluster 1, H4e
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IP6K2 inositol hexakisphosphate kinase 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
LOC157562 uncharacterized LOC157562
LYZL6 lysozyme-like 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR22HG MIR22 host gene
N4BP2L2 NEDD4 binding protein 2-like 2
NRF1 nuclear respiratory factor 1
NUP88 nucleoporin 88kDa
OSGIN1 oxidative stress induced growth inhibitor 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PGF placental growth factor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTX3 pentraxin 3, long
RGS2 regulator of G-protein signaling 2
RSL1D1 ribosomal L1 domain containing 1
SCG5 secretogranin V
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMIM7 small integral membrane protein 7
SPRY4 sprouty homolog 4 (Drosophila)
SYNJ1 synaptojanin 1
TES testin LIM domain protein
TFF2 trefoil factor 2
TG thyroglobulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM36 tripartite motif containing 36
UBE2B ubiquitin-conjugating enzyme E2B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
ZMAT4 zinc finger, matrin-type 4
ZMYM5 zinc finger, MYM-type 5
ZNF280A zinc finger protein 280A
ZNF473 zinc finger protein 473
ZNF654 zinc finger protein 654

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACVR1 activin A receptor, type I
ADCY6 adenylate cyclase 6
AKAP12 A kinase (PRKA) anchor protein 12
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARL4A ADP-ribosylation factor-like 4A
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX5 armadillo repeat containing, X-linked 5
BAMBI BMP and activin membrane-bound inhibitor
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C1D C1D nuclear receptor corepressor
C3ORF52 chromosome 3 open reading frame 52
C9ORF40 chromosome 9 open reading frame 40
CHMP6 charged multivesicular body protein 6
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLDN4 claudin 4
CLK2 CDC-like kinase 2
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COL4A5 collagen, type IV, alpha 5
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFNA1 ephrin-A1
EHD3 EH-domain containing 3
EPHA4 EPH receptor A4
ERCC6L excision repair cross-complementation group 6-like
ETAA1 Ewing tumor-associated antigen 1
FADD Fas (TNFRSF6)-associated via death domain
FANCF Fanconi anemia, complementation group F
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
GATA3 GATA binding protein 3
GEMIN6 gem (nuclear organelle) associated protein 6
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPR87 G protein-coupled receptor 87
GUSBP3 glucuronidase, beta pseudogene 3
HOXC11 homeobox C11
HOXC6 homeobox C6
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLHL9 kelch-like family member 9
LAMA5 laminin, alpha 5
LMNB1 lamin B1
LOC100287590 uncharacterized LOC100287590
LYPD3 LY6/PLAUR domain containing 3
MAGEF1 melanoma antigen family F1
MAP6D1 MAP6 domain containing 1
MAVS mitochondrial antiviral signaling protein
MED7 mediator complex subunit 7
METTL18 methyltransferase like 18
MGA MGA, MAX dimerization protein
MKL2 MKL/myocardin-like 2
MOGS mannosyl-oligosaccharide glucosidase
MSL1 male-specific lethal 1 homolog (Drosophila)
MTCL1 microtubule crosslinking factor 1
NHLRC2 NHL repeat containing 2
NPY1R neuropeptide Y receptor Y1
NUP62CL nucleoporin 62kDa C-terminal like
PANK4 pantothenate kinase 4
PEX11B peroxisomal biogenesis factor 11 beta
PGRMC2 progesterone receptor membrane component 2
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLIN3 perilipin 3
PLK2 polo-like kinase 2
PRKCD protein kinase C, delta
RANBP6 RAN binding protein 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM12 RNA binding motif protein 12
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RPGR retinitis pigmentosa GTPase regulator
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SHPK sedoheptulokinase
SIDT1 SID1 transmembrane family, member 1
SLC35A5 solute carrier family 35, member A5
SPATA7 spermatogenesis associated 7
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TCEAL1 transcription elongation factor A (SII)-like 1
TRPS1 trichorhinophalangeal syndrome I
TTF2 transcription termination factor, RNA polymerase II
TULP4 tubby like protein 4
UNKL unkempt family zinc finger-like
VAV3 vav 3 guanine nucleotide exchange factor
WDR5B WD repeat domain 5B
ZBED5 zinc finger, BED-type containing 5
ZBED8 zinc finger, BED-type containing 8
ZBTB3 zinc finger and BTB domain containing 3
ZC3H4 zinc finger CCCH-type containing 4
ZIC1 Zic family member 1
ZNF180 zinc finger protein 180
ZNF248 zinc finger protein 248
ZNF573 zinc finger protein 573
ZNF652 zinc finger protein 652
ZNHIT2 zinc finger, HIT-type containing 2
ZSCAN31 zinc finger and SCAN domain containing 31