pirenperone-5639 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the pirenperone-5639 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADD2 adducin 2 (beta)
ADGRB1 adhesion G protein-coupled receptor B1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATG10 autophagy related 10
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BARX2 BARX homeobox 2
BLZF1 basic leucine zipper nuclear factor 1
BMP10 bone morphogenetic protein 10
BMP3 bone morphogenetic protein 3
C10ORF95 chromosome 10 open reading frame 95
C1ORF61 chromosome 1 open reading frame 61
C1QL1 complement component 1, q subcomponent-like 1
CAMKV CaM kinase-like vesicle-associated
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD22 CD22 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKL5 cyclin-dependent kinase-like 5
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLSTN2 calsyntenin 2
CLTA clathrin, light chain A
COL4A6 collagen, type IV, alpha 6
CSN2 casein beta
CTIF CBP80/20-dependent translation initiation factor
CYLD cylindromatosis (turban tumor syndrome)
DCTN1 dynactin 1
DGCR8 DGCR8 microprocessor complex subunit
DUSP7 dual specificity phosphatase 7
ESR2 estrogen receptor 2 (ER beta)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF18 fibroblast growth factor 18
FXYD5 FXYD domain containing ion transport regulator 5
GAST gastrin
GJB3 gap junction protein, beta 3, 31kDa
GOLGA8A golgin A8 family, member A
GRM1 glutamate receptor, metabotropic 1
HCAR3 hydroxycarboxylic acid receptor 3
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIC2 hypermethylated in cancer 2
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IDUA iduronidase, alpha-L-
KALRN kalirin, RhoGEF kinase
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF21B kinesin family member 21B
KIF5A kinesin family member 5A
LIMCH1 LIM and calponin homology domains 1
LINC00312 long intergenic non-protein coding RNA 312
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP4 latent transforming growth factor beta binding protein 4
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT6 N-acetyltransferase 6 (GCN5-related)
NCR3 natural cytotoxicity triggering receptor 3
NEK9 NIMA-related kinase 9
NEU3 sialidase 3 (membrane sialidase)
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOVA2 neuro-oncological ventral antigen 2
NPHP4 nephronophthisis 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
PBX2 pre-B-cell leukemia homeobox 2
PDE4DIP phosphodiesterase 4D interacting protein
PDIA2 protein disulfide isomerase family A, member 2
PKNOX2 PBX/knotted 1 homeobox 2
POLL polymerase (DNA directed), lambda
PON3 paraoxonase 3
PORCN porcupine homolog (Drosophila)
PRUNE2 prune homolog 2 (Drosophila)
RHEB Ras homolog enriched in brain
RPAP1 RNA polymerase II associated protein 1
RPL10 ribosomal protein L10
RPL7 ribosomal protein L7
RTEL1 regulator of telomere elongation helicase 1
SARM1 sterile alpha and TIR motif containing 1
SFTPC surfactant protein C
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHOX2 short stature homeobox 2
SKI SKI proto-oncogene
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SPON1 spondin 1, extracellular matrix protein
SPTBN1 spectrin, beta, non-erythrocytic 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAOK2 TAO kinase 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TSSK2 testis-specific serine kinase 2
UPK1A uroplakin 1A
WDR62 WD repeat domain 62
WSCD1 WSC domain containing 1
XAF1 XIAP associated factor 1
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ARMC4 armadillo repeat containing 4
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP15 bone morphogenetic protein 15
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF79 chromosome 14 open reading frame 79
C17ORF80 chromosome 17 open reading frame 80
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC121 coiled-coil domain containing 121
CCDC134 coiled-coil domain containing 134
CES3 carboxylesterase 3
CLGN calmegin
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNR2 cannabinoid receptor 2 (macrophage)
CRLF1 cytokine receptor-like factor 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DENND5B DENN/MADD domain containing 5B
DOCK4 dedicator of cytokinesis 4
DOK5 docking protein 5
EFNA3 ephrin-A3
EPN1 epsin 1
ETNK2 ethanolamine kinase 2
F9 coagulation factor IX
FGD1 FYVE, RhoGEF and PH domain containing 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJA8 gap junction protein, alpha 8, 50kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPR1 G protein-coupled receptor 1
GPR27 G protein-coupled receptor 27
GPR3 G protein-coupled receptor 3
GRPR gastrin-releasing peptide receptor
HDAC11 histone deacetylase 11
HIST1H3E histone cluster 1, H3e
HIST1H4D histone cluster 1, H4d
HOXA4 homeobox A4
HOXB2 homeobox B2
IFT140 intraflagellar transport 140
IL2RB interleukin 2 receptor, beta
INPP1 inositol polyphosphate-1-phosphatase
KCNK12 potassium channel, two pore domain subfamily K, member 12
KRT15 keratin 15, type I
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100286895 cell division cycle 27 homolog pseudogene
LY6D lymphocyte antigen 6 complex, locus D
LZTS3 leucine zipper, putative tumor suppressor family member 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MMP2 matrix metallopeptidase 2
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEUROD4 neuronal differentiation 4
NLRX1 NLR family member X1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
OSMR oncostatin M receptor
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHA9 protocadherin alpha 9
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGPEP1 pyroglutamyl-peptidase I
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLA2G10 phospholipase A2, group X
RAB30 RAB30, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFXAP regulatory factor X-associated protein
RHOBTB2 Rho-related BTB domain containing 2
RRAGB Ras-related GTP binding B
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCARA3 scavenger receptor class A, member 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT2 sirtuin 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SPAG4 sperm associated antigen 4
STRN striatin, calmodulin binding protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFF2 trefoil factor 2
TGFBR1 transforming growth factor, beta receptor 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM242 transmembrane protein 242
TMEM45A transmembrane protein 45A
TTBK2 tau tubulin kinase 2
TUBA3C tubulin, alpha 3c
XDH xanthine dehydrogenase
ZBTB33 zinc finger and BTB domain containing 33
ZFP37 ZFP37 zinc finger protein
ZIC3 Zic family member 3
ZNF10 zinc finger protein 10
ZNF446 zinc finger protein 446
ZNF480 zinc finger protein 480
ZW10 zw10 kinetochore protein