pirenzepine-2234 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pirenzepine-2234 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
ADAM8 ADAM metallopeptidase domain 8
ADAMDEC1 ADAM-like, decysin 1
AKAP13 A kinase (PRKA) anchor protein 13
ALCAM activated leukocyte cell adhesion molecule
ALPPL2 alkaline phosphatase, placental-like 2
AMPD3 adenosine monophosphate deaminase 3
APOL6 apolipoprotein L, 6
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP11A ATPase, class VI, type 11A
BIN1 bridging integrator 1
BTN3A3 butyrophilin, subfamily 3, member A3
C1ORF68 chromosome 1 open reading frame 68
C2 complement component 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNK cyclin K
CDRT1 CMT1A duplicated region transcript 1
CFHR4 complement factor H-related 4
CHM choroideremia (Rab escort protein 1)
CLIC2 chloride intracellular channel 2
COL1A1 collagen, type I, alpha 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DLK2 delta-like 2 homolog (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DNAAF1 dynein, axonemal, assembly factor 1
DPF1 D4, zinc and double PHD fingers family 1
DSTYK dual serine/threonine and tyrosine protein kinase
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
FBLN1 fibulin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL1 four and a half LIM domains 1
FKRP fukutin related protein
FRMD1 FERM domain containing 1
FRMD4A FERM domain containing 4A
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GK3P glycerol kinase 3 pseudogene
HBEGF heparin-binding EGF-like growth factor
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIST1H3I histone cluster 1, H3i
HOXD1 homeobox D1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICOSLG inducible T-cell co-stimulator ligand
IL11RA interleukin 11 receptor, alpha
IL1RN interleukin 1 receptor antagonist
INO80D INO80 complex subunit D
IQCA1 IQ motif containing with AAA domain 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0040 KIAA0040
KLF8 Kruppel-like factor 8
KLHL29 kelch-like family member 29
KLK2 kallikrein-related peptidase 2
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LMNA lamin A/C
MALL mal, T-cell differentiation protein-like
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECOM MDS1 and EVI1 complex locus
MKL1 megakaryoblastic leukemia (translocation) 1
MOBP myelin-associated oligodendrocyte basic protein
MUC2 mucin 2, oligomeric mucus/gel-forming
MYL10 myosin, light chain 10, regulatory
N4BP2L1 NEDD4 binding protein 2-like 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NF2 neurofibromin 2 (merlin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
OXCT2 3-oxoacid CoA transferase 2
PARD6B par-6 family cell polarity regulator beta
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PENK proenkephalin
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKP2 plakophilin 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK3 polo-like kinase 3
PML promyelocytic leukemia
PPARA peroxisome proliferator-activated receptor alpha
PSAT1 phosphoserine aminotransferase 1
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RND1 Rho family GTPase 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RUNX1 runt-related transcription factor 1
SDC2 syndecan 2
SERHL2 serine hydrolase-like 2
SH3GL3 SH3-domain GRB2-like 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC22A14 solute carrier family 22, member 14
SMAD1 SMAD family member 1
SPDEF SAM pointed domain containing ETS transcription factor
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SYNJ1 synaptojanin 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBXA2R thromboxane A2 receptor
TM4SF5 transmembrane 4 L six family member 5
TRIM29 tripartite motif containing 29
USB1 U6 snRNA biogenesis 1
ZNF821 zinc finger protein 821
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADGRE5 adhesion G protein-coupled receptor E5
AFAP1 actin filament associated protein 1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMC4 armadillo repeat containing 4
ARRB1 arrestin, beta 1
ARSB arylsulfatase B
ATAT1 alpha tubulin acetyltransferase 1
C16ORF58 chromosome 16 open reading frame 58
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCNO cyclin O
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK3 cyclin-dependent kinase 3
CEL carboxyl ester lipase
CEMIP cell migration inducing protein, hyaluronan binding
CEP170B centrosomal protein 170B
CGREF1 cell growth regulator with EF-hand domain 1
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CORO7 coronin 7
CORT cortistatin
CSF1R colony stimulating factor 1 receptor
CUL9 cullin 9
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPY19L1P1 DPY19L1 pseudogene 1
FBXL7 F-box and leucine-rich repeat protein 7
FER fer (fps/fes related) tyrosine kinase
FLT4 fms-related tyrosine kinase 4
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPR143 G protein-coupled receptor 143
GPRC5D G protein-coupled receptor, class C, group 5, member D
HIST1H1D histone cluster 1, H1d
HIST1H3B histone cluster 1, H3b
HOXA4 homeobox A4
HPN hepsin
INPP1 inositol polyphosphate-1-phosphatase
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0894 KIAA0894 protein
KIAA0895 KIAA0895
KIF13B kinesin family member 13B
KRT15 keratin 15, type I
LHX1 LIM homeobox 1
LHX6 LIM homeobox 6
LRRC49 leucine rich repeat containing 49
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAPKBP1 mitogen-activated protein kinase binding protein 1
MVP major vault protein
MYOZ1 myozenin 1
NECAP2 NECAP endocytosis associated 2
NEUROD4 neuronal differentiation 4
NOL12 nucleolar protein 12
OSGIN1 oxidative stress induced growth inhibitor 1
OVGP1 oviductal glycoprotein 1, 120kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PALM paralemmin
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITX2 paired-like homeodomain 2
PKN1 protein kinase N1
PNPLA6 patatin-like phospholipase domain containing 6
POLL polymerase (DNA directed), lambda
PROS1 protein S (alpha)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RUNDC3B RUN domain containing 3B
SAYSD1 SAYSVFN motif domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SEC14L5 SEC14-like 5 (S. cerevisiae)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIPA1 signal-induced proliferation-associated 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SPRYD7 SPRY domain containing 7
SYNC syncoilin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TICAM1 toll-like receptor adaptor molecule 1
TLN1 talin 1
TM6SF1 transmembrane 6 superfamily member 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TTBK2 tau tubulin kinase 2
TYRP1 tyrosinase-related protein 1
UNC119 unc-119 homolog (C. elegans)
UPK3B uroplakin 3B
VEGFB vascular endothelial growth factor B
WFDC2 WAP four-disulfide core domain 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF134 zinc finger protein 134
ZNF778 zinc finger protein 778