piribedil-5434 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the piribedil-5434 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ADAM8 ADAM metallopeptidase domain 8
AIF1 allograft inflammatory factor 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
ATAT1 alpha tubulin acetyltransferase 1
ATF5 activating transcription factor 5
ATN1 atrophin 1
AVPR1B arginine vasopressin receptor 1B
BMP5 bone morphogenetic protein 5
C11ORF63 chromosome 11 open reading frame 63
C2CD2L C2CD2-like
C4BPA complement component 4 binding protein, alpha
C6ORF10 chromosome 6 open reading frame 10
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCL13 chemokine (C-C motif) ligand 13
CD52 CD52 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLDN17 claudin 17
CPB1 carboxypeptidase B1 (tissue)
CTIF CBP80/20-dependent translation initiation factor
DIXDC1 DIX domain containing 1
DKFZP434C153 DKFZP434C153 protein
DLX4 distal-less homeobox 4
DMPK dystrophia myotonica-protein kinase
EDA ectodysplasin A
EDNRA endothelin receptor type A
FABP3 fatty acid binding protein 3, muscle and heart
FAM46C family with sequence similarity 46, member C
GM2A GM2 ganglioside activator
GSTTP1 glutathione S-transferase theta pseudogene 1
HDAC7 histone deacetylase 7
HOXA4 homeobox A4
HPX hemopexin
IQSEC2 IQ motif and Sec7 domain 2
JMJD6 jumonji domain containing 6
LGALS9 lectin, galactoside-binding, soluble, 9
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMF2 lipase maturation factor 2
LOC644450 uncharacterized LOC644450
LSP1 lymphocyte-specific protein 1
MAL mal, T-cell differentiation protein
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP4 microtubule-associated protein 4
MATN3 matrilin 3
MBD2 methyl-CpG binding domain protein 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MOGAT2 monoacylglycerol O-acyltransferase 2
MTAP methylthioadenosine phosphorylase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OPRK1 opioid receptor, kappa 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCSK6 proprotein convertase subtilisin/kexin type 6
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
POFUT1 protein O-fucosyltransferase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS10 regulator of G-protein signaling 10
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPL23AP32 ribosomal protein L23a pseudogene 32
RYR3 ryanodine receptor 3
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERHL2 serine hydrolase-like 2
SIRT5 sirtuin 5
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNTA1 syntrophin, alpha 1
SPDEF SAM pointed domain containing ETS transcription factor
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRR1B small proline-rich protein 1B
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBX2 T-box 2
TBX3 T-box 3
TBXA2R thromboxane A2 receptor
TEX15 testis expressed 15
TM4SF4 transmembrane 4 L six family member 4
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
UTRN utrophin
XIST X inactive specific transcript (non-protein coding)
YPEL1 yippee-like 1 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24
ZHX3 zinc fingers and homeoboxes 3
ZNF358 zinc finger protein 358
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
AGMAT agmatine ureohydrolase (agmatinase)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
AOC2 amine oxidase, copper containing 2 (retina-specific)
APOLD1 apolipoprotein L domain containing 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASTE1 asteroid homolog 1 (Drosophila)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BIRC7 baculoviral IAP repeat containing 7
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CACFD1 calcium channel flower domain containing 1
CAPN5 calpain 5
CCDC186 coiled-coil domain containing 186
CCDC71 coiled-coil domain containing 71
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNR2 cannabinoid receptor 2 (macrophage)
CTAGE9 CTAGE family, member 9
CXADR coxsackie virus and adenovirus receptor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGKE diacylglycerol kinase, epsilon 64kDa
FBXL15 F-box and leucine-rich repeat protein 15
FBXO4 F-box protein 4
FGD1 FYVE, RhoGEF and PH domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR143 G protein-coupled receptor 143
HHAT hedgehog acyltransferase
HIST1H2AL histone cluster 1, H2al
HIST1H4A histone cluster 1, H4a
HIST2H2AA3 histone cluster 2, H2aa3
IFI6 interferon, alpha-inducible protein 6
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA0754 KIAA0754
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LAMC3 laminin, gamma 3
LAX1 lymphocyte transmembrane adaptor 1
LEFTY1 left-right determination factor 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MDM4 MDM4, p53 regulator
MGC12488
MRPS18C mitochondrial ribosomal protein S18C
MUC3A mucin 3A, cell surface associated
NOL10 nucleolar protein 10
NT5E 5'-nucleotidase, ecto (CD73)
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHA9 protocadherin alpha 9
PCDHGA10 protocadherin gamma subfamily A, 10
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
POLH polymerase (DNA directed), eta
RAB11B RAB11B, member RAS oncogene family
RAB30 RAB30, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFXAP regulatory factor X-associated protein
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF170 ring finger protein 170
RPL10L ribosomal protein L10-like
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A9 S100 calcium binding protein A9
SCRN3 secernin 3
SKI SKI proto-oncogene
SLC35F5 solute carrier family 35, member F5
SLN sarcolipin
SMIM14 small integral membrane protein 14
SP1 Sp1 transcription factor
SPON2 spondin 2, extracellular matrix protein
STK16 serine/threonine kinase 16
STRA6 stimulated by retinoic acid 6
STRN striatin, calmodulin binding protein
TBL1Y transducin (beta)-like 1, Y-linked
TESC tescalcin
TMEM209 transmembrane protein 209
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRAIP TRAF interacting protein
UBQLN4 ubiquilin 4
USP20 ubiquitin specific peptidase 20
ZNF10 zinc finger protein 10
ZNF141 zinc finger protein 141
ZNF606 zinc finger protein 606