pirinixic acid-481 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the pirinixic acid-481 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACAA2 acetyl-CoA acyltransferase 2
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADARB1 adenosine deaminase, RNA-specific, B1
AEN apoptosis enhancing nuclease
ANGPTL4 angiopoietin-like 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CCHCR1 coiled-coil alpha-helical rod protein 1
CD70 CD70 molecule
CLDN15 claudin 15
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DRD2 dopamine receptor D2
ELF4 E74-like factor 4 (ets domain transcription factor)
ELL elongation factor RNA polymerase II
ERCC1 excision repair cross-complementation group 1
FABP4 fatty acid binding protein 4, adipocyte
FLOT1 flotillin 1
FXR2 fragile X mental retardation, autosomal homolog 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GK3P glycerol kinase 3 pseudogene
GP2 glycoprotein 2 (zymogen granule membrane)
GPR107 G protein-coupled receptor 107
GPR3 G protein-coupled receptor 3
GUCA1B guanylate cyclase activator 1B (retina)
GYPB glycophorin B (MNS blood group)
HN1L hematological and neurological expressed 1-like
HPX hemopexin
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIF1C kinesin family member 1C
KLK13 kallikrein-related peptidase 13
KLK3 kallikrein-related peptidase 3
KRI1 KRI1 homolog (S. cerevisiae)
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LOC100131510 uncharacterized LOC100131510
LPIN1 lipin 1
LUZP4 leucine zipper protein 4
MAN1B1 mannosidase, alpha, class 1B, member 1
MAST2 microtubule associated serine/threonine kinase 2
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MON1B MON1 secretory trafficking family member B
MST1 macrophage stimulating 1
MTMR10 myotubularin related protein 10
MUC2 mucin 2, oligomeric mucus/gel-forming
MYL10 myosin, light chain 10, regulatory
NADK NAD kinase
NCR2 natural cytotoxicity triggering receptor 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMT1 N-myristoyltransferase 1
NPHP4 nephronophthisis 4
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
NVL nuclear VCP-like
ORC4 origin recognition complex, subunit 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAIP2B poly(A) binding protein interacting protein 2B
PARM1 prostate androgen-regulated mucin-like protein 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDZD7 PDZ domain containing 7
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCL2 phospholipase C-like 2
PLIN2 perilipin 2
PMEL premelanosome protein
PRKCD protein kinase C, delta
PRND prion protein 2 (dublet)
RASAL1 RAS protein activator like 1 (GAP1 like)
RBM5 RNA binding motif protein 5
RGS14 regulator of G-protein signaling 14
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A12 S100 calcium binding protein A12
SETD4 SET domain containing 4
SGSM3 small G protein signaling modulator 3
SIRT3 sirtuin 3
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMAD6 SMAD family member 6
SOCS1 suppressor of cytokine signaling 1
SORBS3 sorbin and SH3 domain containing 3
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYNGR1 synaptogyrin 1
SYNPO synaptopodin
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TMPRSS5 transmembrane protease, serine 5
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TOB2 transducer of ERBB2, 2
TOP3A topoisomerase (DNA) III alpha
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSC22D3 TSC22 domain family, member 3
VENTX VENT homeobox

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACOT9 acyl-CoA thioesterase 9
AK5 adenylate kinase 5
ALG12 ALG12, alpha-1,6-mannosyltransferase
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARHGAP5 Rho GTPase activating protein 5
ARRB2 arrestin, beta 2
ASIP agouti signaling protein
ATF7IP2 activating transcription factor 7 interacting protein 2
ATXN8OS ATXN8 opposite strand (non-protein coding)
BMPR1B bone morphogenetic protein receptor, type IB
C19ORF57 chromosome 19 open reading frame 57
C4BPA complement component 4 binding protein, alpha
CA11 carbonic anhydrase XI
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAV3 caveolin 3
CCL16 chemokine (C-C motif) ligand 16
CD5 CD5 molecule
CDC73 cell division cycle 73
CHAT choline O-acetyltransferase
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLDN17 claudin 17
CLEC4E C-type lectin domain family 4, member E
COQ4 coenzyme Q4
CORO2B coronin, actin binding protein, 2B
CPOX coproporphyrinogen oxidase
CRMP1 collapsin response mediator protein 1
CSRNP3 cysteine-serine-rich nuclear protein 3
CST2 cystatin SA
CTGF connective tissue growth factor
CYBA cytochrome b-245, alpha polypeptide
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHRS11 dehydrogenase/reductase (SDR family) member 11
DOK3 docking protein 3
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EFNA1 ephrin-A1
EFNA3 ephrin-A3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAIM Fas apoptotic inhibitory molecule
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOLR2 folate receptor 2 (fetal)
FSCN3 fascin actin-bundling protein 3, testicular
GDF3 growth differentiation factor 3
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HP1BP3 heterochromatin protein 1, binding protein 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT22 intraflagellar transport 22
IL18RAP interleukin 18 receptor accessory protein
KIAA0509 uncharacterized LOC57242
KIF23 kinesin family member 23
KIFAP3 kinesin-associated protein 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LENEP lens epithelial protein
LINC00574 long intergenic non-protein coding RNA 574
LINC01558 long intergenic non-protein coding RNA 1558
LOC440895 two pore channel 3 pseudogene
LRRC32 leucine rich repeat containing 32
LZTS3 leucine zipper, putative tumor suppressor family member 3
MMP8 matrix metallopeptidase 8
MT1M metallothionein 1M
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NAT6 N-acetyltransferase 6 (GCN5-related)
NCAPH non-SMC condensin I complex, subunit H
NOL12 nucleolar protein 12
NPIPB15 nuclear pore complex interacting protein family, member B15
OLFML2B olfactomedin-like 2B
OXT oxytocin/neurophysin I prepropeptide
PALMD palmdelphin
PCDHB6 protocadherin beta 6
PCOLCE procollagen C-endopeptidase enhancer
PLA2G10 phospholipase A2, group X
PODNL1 podocan-like 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PQLC3 PQ loop repeat containing 3
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
RDH8 retinol dehydrogenase 8 (all-trans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPANXC SPANX family, member C
STXBP5L syntaxin binding protein 5-like
SYT2 synaptotagmin II
T T, brachyury homolog (mouse)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TET3 tet methylcytosine dioxygenase 3
TMEM143 transmembrane protein 143
TMEM209 transmembrane protein 209
TMEM8A transmembrane protein 8A
TSPAN32 tetraspanin 32
TUBA4B tubulin, alpha 4b
VEGFB vascular endothelial growth factor B
WLS wntless Wnt ligand secretion mediator
WWC2 WW and C2 domain containing 2
XYLT1 xylosyltransferase I