pirinixic acid-495 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the pirinixic acid-495 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADM2 adrenomedullin 2
AFF1 AF4/FMR2 family, member 1
AMPD3 adenosine monophosphate deaminase 3
ANAPC2 anaphase promoting complex subunit 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARR3 arrestin 3, retinal (X-arrestin)
ASB13 ankyrin repeat and SOCS box containing 13
ASRGL1 asparaginase like 1
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C11ORF68 chromosome 11 open reading frame 68
C6ORF47 chromosome 6 open reading frame 47
CACFD1 calcium channel flower domain containing 1
CCDC71 coiled-coil domain containing 71
CD22 CD22 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFAP70 cilia and flagella associated protein 70
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL11A2 collagen, type XI, alpha 2
DCLRE1C DNA cross-link repair 1C
DCTN2 dynactin 2 (p50)
DLK2 delta-like 2 homolog (Drosophila)
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DRP2 dystrophin related protein 2
DSCAM Down syndrome cell adhesion molecule
EGR4 early growth response 4
FBXO11 F-box protein 11
FGFBP1 fibroblast growth factor binding protein 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
HFE hemochromatosis
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IRGQ immunity-related GTPase family, Q
KIAA0509 uncharacterized LOC57242
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LAPTM5 lysosomal protein transmembrane 5
MEF2D myocyte enhancer factor 2D
MMP25 matrix metallopeptidase 25
MYL10 myosin, light chain 10, regulatory
NABP2 nucleic acid binding protein 2
NDRG2 NDRG family member 2
NPAT nuclear protein, ataxia-telangiectasia locus
NPTX1 neuronal pentraxin I
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALM paralemmin
PDE12 phosphodiesterase 12
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP prolactin-induced protein
PLAUR plasminogen activator, urokinase receptor
PPAN peter pan homolog (Drosophila)
PRB1 proline-rich protein BstNI subfamily 1
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRPF31 pre-mRNA processing factor 31
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
R3HDM1 R3H domain containing 1
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RGS11 regulator of G-protein signaling 11
RLN2 relaxin 2
RPS2 ribosomal protein S2
RRP1B ribosomal RNA processing 1B
SEC23A Sec23 homolog A (S. cerevisiae)
SEC23IP SEC23 interacting protein
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIK3 SIK family kinase 3
SLIT2 slit homolog 2 (Drosophila)
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SOX14 SRY (sex determining region Y)-box 14
SPDEF SAM pointed domain containing ETS transcription factor
SPN sialophorin
STAT5A signal transducer and activator of transcription 5A
TCF3 transcription factor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM161A transmembrane protein 161A
TNNT1 troponin T type 1 (skeletal, slow)
TRIM14 tripartite motif containing 14
TRIM23 tripartite motif containing 23
TUBA4B tubulin, alpha 4b
UBA6 ubiquitin-like modifier activating enzyme 6
USF2 upstream transcription factor 2, c-fos interacting
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR48 WD repeat domain 48
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
YBX2 Y box binding protein 2
ZC3H12A zinc finger CCCH-type containing 12A
ZCCHC4 zinc finger, CCHC domain containing 4
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF287 zinc finger protein 287
ZNF32 zinc finger protein 32
ZNF460 zinc finger protein 460
ZNF586 zinc finger protein 586
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ALPK1 alpha-kinase 1
ARSA arylsulfatase A
ASTE1 asteroid homolog 1 (Drosophila)
AXIN1 axin 1
BARD1 BRCA1 associated RING domain 1
BBC3 BCL2 binding component 3
BEST1 bestrophin 1
C1ORF95 chromosome 1 open reading frame 95
CA6 carbonic anhydrase VI
CBY1 chibby homolog 1 (Drosophila)
CCP110 centriolar coiled coil protein 110kDa
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CEP41 centrosomal protein 41kDa
CLDN17 claudin 17
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNTD2 cyclin N-terminal domain containing 2
COCH cochlin
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYSLTR2 cysteinyl leukotriene receptor 2
DCPS decapping enzyme, scavenger
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DPP3 dipeptidyl-peptidase 3
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EPHA4 EPH receptor A4
FAM188A family with sequence similarity 188, member A
FAM63A family with sequence similarity 63, member A
FANCG Fanconi anemia, complementation group G
FLCN folliculin
FOXF1 forkhead box F1
FSHB follicle stimulating hormone, beta polypeptide
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAMT guanidinoacetate N-methyltransferase
GLRA2 glycine receptor, alpha 2
GRHL2 grainyhead-like 2 (Drosophila)
GUCA2A guanylate cyclase activator 2A (guanylin)
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HHAT hedgehog acyltransferase
HMBOX1 homeobox containing 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPB6 heat shock protein, alpha-crystallin-related, B6
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL15RA interleukin 15 receptor, alpha
IRF8 interferon regulatory factor 8
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIFC1 kinesin family member C1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KLK12 kallikrein-related peptidase 12
KRT85 keratin 85, type II
LAMA1 laminin, alpha 1
LHFP lipoma HMGIC fusion partner
LIF leukemia inhibitory factor
LMAN2L lectin, mannose-binding 2-like
LRRC20 leucine rich repeat containing 20
MAB21L1 mab-21-like 1 (C. elegans)
METTL4 methyltransferase like 4
MT1HL1 metallothionein 1H-like 1
NOS2 nitric oxide synthase 2, inducible
NOTCH4 notch 4
OCEL1 occludin/ELL domain containing 1
OPRK1 opioid receptor, kappa 1
PANK4 pantothenate kinase 4
PC pyruvate carboxylase
PHACTR4 phosphatase and actin regulator 4
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R26 protein phosphatase 1, regulatory subunit 26
PPP4C protein phosphatase 4, catalytic subunit
PRY PTPN13-like, Y-linked
RAB3A RAB3A, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RCOR3 REST corepressor 3
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RRH retinal pigment epithelium-derived rhodopsin homolog
SELL selectin L
SH2D4A SH2 domain containing 4A
SH3D21 SH3 domain containing 21
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLPI secretory leukocyte peptidase inhibitor
SNX6 sorting nexin 6
SPATA20 spermatogenesis associated 20
TM4SF5 transmembrane 4 L six family member 5
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TP53BP1 tumor protein p53 binding protein 1
TRPS1 trichorhinophalangeal syndrome I
TSHB thyroid stimulating hormone, beta
TTC4 tetratricopeptide repeat domain 4
TTTY15 testis-specific transcript, Y-linked 15 (non-protein coding)
TUBG2 tubulin, gamma 2
ZFHX4 zinc finger homeobox 4