pirlindole-3140 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pirlindole-3140 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP8L A kinase (PRKA) anchor protein 8-like
ANG angiogenin, ribonuclease, RNase A family, 5
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
AQP7 aquaporin 7
BTF3P11 basic transcription factor 3 pseudogene 11
C16ORF45 chromosome 16 open reading frame 45
C6ORF10 chromosome 6 open reading frame 10
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CASZ1 castor zinc finger 1
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC71 coiled-coil domain containing 71
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHD5 chromodomain helicase DNA binding protein 5
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCA1 chloride channel accessory 1
COL6A1 collagen, type VI, alpha 1
COPE coatomer protein complex, subunit epsilon
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRYM crystallin, mu
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DCAF4 DDB1 and CUL4 associated factor 4
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DPF1 D4, zinc and double PHD fingers family 1
ENDOD1 endonuclease domain containing 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
EXPH5 exophilin 5
F5 coagulation factor V (proaccelerin, labile factor)
FBXO31 F-box protein 31
FER1L4 fer-1-like family member 4, pseudogene (functional)
FGF6 fibroblast growth factor 6
FRMD8 FERM domain containing 8
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GJA4 gap junction protein, alpha 4, 37kDa
GLG1 golgi glycoprotein 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIST1H2AB histone cluster 1, H2ab
HOXA10 homeobox A10
IFNA14 interferon, alpha 14
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R2 interleukin 1 receptor, type II
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KIF1C kinesin family member 1C
LAD1 ladinin 1
LEF1 lymphoid enhancer-binding factor 1
LHX2 LIM homeobox 2
LOXL3 lysyl oxidase-like 3
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MARC1 mitochondrial amidoxime reducing component 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NAG18 NAG18 mRNA
NBL1 neuroblastoma 1, DAN family BMP antagonist
NR1I2 nuclear receptor subfamily 1, group I, member 2
PBX2 pre-B-cell leukemia homeobox 2
PCDH11Y protocadherin 11 Y-linked
PER3 period circadian clock 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PRAMEF11 PRAME family member 11
PRB1 proline-rich protein BstNI subfamily 1
PRSS53 protease, serine, 53
PRSS8 protease, serine, 8
PTGER3 prostaglandin E receptor 3 (subtype EP3)
REC8 REC8 meiotic recombination protein
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SCAMP5 secretory carrier membrane protein 5
SCAND2P SCAN domain containing 2 pseudogene
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLIT1 slit homolog 1 (Drosophila)
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPATA2L spermatogenesis associated 2-like
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAPT1 transmembrane anterior posterior transformation 1
TCHH trichohyalin
TEF thyrotrophic embryonic factor
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TK2 thymidine kinase 2, mitochondrial
TM4SF1 transmembrane 4 L six family member 1
TM4SF5 transmembrane 4 L six family member 5
TMC7 transmembrane channel-like 7
TRD T cell receptor delta locus
TRIM58 tripartite motif containing 58
TSFM Ts translation elongation factor, mitochondrial
TULP1 tubby like protein 1
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WIZ widely interspaced zinc finger motifs
WSCD1 WSC domain containing 1
ZMAT4 zinc finger, matrin-type 4
ZNF549 zinc finger protein 549
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADAMDEC1 ADAM-like, decysin 1
ANAPC2 anaphase promoting complex subunit 2
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B3GNT1
BEND5 BEN domain containing 5
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C19ORF40 chromosome 19 open reading frame 40
C7ORF43 chromosome 7 open reading frame 43
CCNT1 cyclin T1
CD180 CD180 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CECR1 cat eye syndrome chromosome region, candidate 1
CEP72 centrosomal protein 72kDa
CLDN7 claudin 7
CNTN1 contactin 1
COL9A2 collagen, type IX, alpha 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHDDS dehydrodolichyl diphosphate synthase
DPY19L1P1 DPY19L1 pseudogene 1
EDAR ectodysplasin A receptor
ELP6 elongator acetyltransferase complex subunit 6
FAM204A family with sequence similarity 204, member A
FBRS fibrosin
FBXL6 F-box and leucine-rich repeat protein 6
FHIT fragile histidine triad
FKBP9 FK506 binding protein 9, 63 kDa
FZD6 frizzled class receptor 6
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
HYAL2 hyaluronoglucosaminidase 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL4R interleukin 4 receptor
ISG15 ISG15 ubiquitin-like modifier
JADE3 jade family PHD finger 3
JAM2 junctional adhesion molecule 2
KAT2A K(lysine) acetyltransferase 2A
KDM5C lysine (K)-specific demethylase 5C
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LOC100286895 cell division cycle 27 homolog pseudogene
LRRK1 leucine-rich repeat kinase 1
LSP1 lymphocyte-specific protein 1
LTBP2 latent transforming growth factor beta binding protein 2
LZTR1 leucine-zipper-like transcription regulator 1
MAGEF1 melanoma antigen family F1
MBIP MAP3K12 binding inhibitory protein 1
METTL1 methyltransferase like 1
MLLT4-AS1 MLLT4 antisense RNA 1 (head to head)
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MX1 MX dynamin-like GTPase 1
NCALD neurocalcin delta
NDE1 nudE neurodevelopment protein 1
NINJ2 ninjurin 2
NSUN6 NOP2/Sun domain family, member 6
NTHL1 nth endonuclease III-like 1 (E. coli)
NXPH4 neurexophilin 4
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PNOC prepronociceptin
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP17 RAN binding protein 17
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNF126P1 ring finger protein 126 pseudogene 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SETD6 SET domain containing 6
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIK1 salt-inducible kinase 1
SLC35F6 solute carrier family 35, member F6
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SPATA20 spermatogenesis associated 20
SPRYD7 SPRY domain containing 7
ST7L suppression of tumorigenicity 7 like
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBC1D19 TBC1 domain family, member 19
TBL3 transducin (beta)-like 3
TMEM180 transmembrane protein 180
TMEM206 transmembrane protein 206
TRIM45 tripartite motif containing 45
USP27X ubiquitin specific peptidase 27, X-linked
ZC3H12A zinc finger CCCH-type containing 12A
ZFHX4 zinc finger homeobox 4
ZIM2 zinc finger, imprinted 2
ZNF280B zinc finger protein 280B
ZNF408 zinc finger protein 408
ZNF574 zinc finger protein 574
ZNF668 zinc finger protein 668
ZNF76 zinc finger protein 76
ZNF778 zinc finger protein 778