pizotifen-3134 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pizotifen-3134 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACTN1 actinin, alpha 1
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AHCYL2 adenosylhomocysteinase-like 2
AIRE autoimmune regulator
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
BLZF1 basic leucine zipper nuclear factor 1
BTF3P11 basic transcription factor 3 pseudogene 11
BTNL3 butyrophilin-like 3
C1ORF61 chromosome 1 open reading frame 61
C1ORF68 chromosome 1 open reading frame 68
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CAPN3 calpain 3, (p94)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CLEC1B C-type lectin domain family 1, member B
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COL7A1 collagen, type VII, alpha 1
COPE coatomer protein complex, subunit epsilon
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND2 catenin (cadherin-associated protein), delta 2
CUX2 cut-like homeobox 2
CXCR3 chemokine (C-X-C motif) receptor 3
DFNB31 deafness, autosomal recessive 31
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
F12 coagulation factor XII (Hageman factor)
FAM76A family with sequence similarity 76, member A
FBXL7 F-box and leucine-rich repeat protein 7
FN1 fibronectin 1
FYB FYN binding protein
GLP1R glucagon-like peptide 1 receptor
GPR22 G protein-coupled receptor 22
GRM8 glutamate receptor, metabotropic 8
GSTA3 glutathione S-transferase alpha 3
HCG4 HLA complex group 4 (non-protein coding)
HDAC6 histone deacetylase 6
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HSPA2 heat shock 70kDa protein 2
HYAL1 hyaluronoglucosaminidase 1
IL37 interleukin 37
KLHL36 kelch-like family member 36
KRT18 keratin 18, type I
KRT81 keratin 81, type II
LAMB4 laminin, beta 4
LCMT2 leucine carboxyl methyltransferase 2
LHX2 LIM homeobox 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP4 microtubule-associated protein 4
MAPK13 mitogen-activated protein kinase 13
MARC2 mitochondrial amidoxime reducing component 2
MID2 midline 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MLN motilin
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAM1 neural cell adhesion molecule 1
NCOR2 nuclear receptor corepressor 2
NES nestin
PARP3 poly (ADP-ribose) polymerase family, member 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIDD1 p53-induced death domain protein 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB27B RAB27B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RUSC2 RUN and SH3 domain containing 2
SBNO2 strawberry notch homolog 2 (Drosophila)
SLC17A2 solute carrier family 17, member 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SOCS2 suppressor of cytokine signaling 2
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPRR3 small proline-rich protein 3
THRB thyroid hormone receptor, beta
TJAP1 tight junction associated protein 1 (peripheral)
TP63 tumor protein p63
TRIM3 tripartite motif containing 3
TSC2 tuberous sclerosis 2
TSC22D2 TSC22 domain family, member 2
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL7 tubulin tyrosine ligase-like family member 7
UBOX5 U-box domain containing 5
VIPR2 vasoactive intestinal peptide receptor 2
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
YLPM1 YLP motif containing 1
ZC3H7B zinc finger CCCH-type containing 7B
ZER1 zyg-11 related, cell cycle regulator
ZNF137P zinc finger protein 137, pseudogene
ZNF174 zinc finger protein 174
ZNF407 zinc finger protein 407
ZNF471 zinc finger protein 471

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACP6 acid phosphatase 6, lysophosphatidic
ADAM23 ADAM metallopeptidase domain 23
ADAMDEC1 ADAM-like, decysin 1
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ARMC6 armadillo repeat containing 6
ATG10 autophagy related 10
ATG9A autophagy related 9A
BEST1 bestrophin 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C1ORF105 chromosome 1 open reading frame 105
CBX7 chromobox homolog 7
CCDC9 coiled-coil domain containing 9
CD300C CD300c molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CENPB centromere protein B, 80kDa
CIDEC cell death-inducing DFFA-like effector c
CLIP2 CAP-GLY domain containing linker protein 2
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
EMILIN2 elastin microfibril interfacer 2
ERCC2 excision repair cross-complementation group 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FCMR Fc fragment of IgM receptor
FMO4 flavin containing monooxygenase 4
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPX2 glutathione peroxidase 2
HIST1H3B histone cluster 1, H3b
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL24 interleukin 24
KIAA0319L KIAA0319-like
KIAA0754 KIAA0754
LAMP5 lysosomal-associated membrane protein family, member 5
LINC00216 long intergenic non-protein coding RNA 216
LOC100286895 cell division cycle 27 homolog pseudogene
LOC100287590 uncharacterized LOC100287590
LRRC20 leucine rich repeat containing 20
LTBP2 latent transforming growth factor beta binding protein 2
MAST3 microtubule associated serine/threonine kinase 3
MEFV Mediterranean fever
MEGF8 multiple EGF-like-domains 8
MKRN3 makorin ring finger protein 3
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NBEA neurobeachin
NINJ2 ninjurin 2
NSUN6 NOP2/Sun domain family, member 6
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCDHGA10 protocadherin gamma subfamily A, 10
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PMP22 peripheral myelin protein 22
PNOC prepronociceptin
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRF1 perforin 1 (pore forming protein)
PRKCZ protein kinase C, zeta
PSKH1 protein serine kinase H1
PTCD1 pentatricopeptide repeat domain 1
PYGB phosphorylase, glycogen; brain
RAP1GAP2 RAP1 GTPase activating protein 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF122 ring finger protein 122
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPP25 ribonuclease P/MRP 25kDa subunit
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SIK1 salt-inducible kinase 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F6 solute carrier family 35, member F6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
TIGD6 tigger transposable element derived 6
TMEM180 transmembrane protein 180
TMEM19 transmembrane protein 19
TRAF2 TNF receptor-associated factor 2
TSPAN13 tetraspanin 13
TSSC4 tumor suppressing subtransferable candidate 4
TUBA4B tubulin, alpha 4b
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF185 zinc finger protein 185 (LIM domain)
ZNF408 zinc finger protein 408
ZNF492 zinc finger protein 492
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862