placental insufficiency Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy. (Human Disease Ontology, DOID_3891)
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Genes

150 genes co-occuring with the disease placental insufficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 1.7921
CSH2 chorionic somatomammotropin hormone 2 1.76773
PSG8 pregnancy specific beta-1-glycoprotein 8 1.30882
LGALS1 lectin, galactoside-binding, soluble, 1 1.28872
LNPEP leucyl/cystinyl aminopeptidase 1.1367
HSDL1 hydroxysteroid dehydrogenase like 1 1.05597
FLNB filamin B, beta 1.03746
GCM1 glial cells missing homolog 1 (Drosophila) 1.01723
FUCA2 fucosidase, alpha-L- 2, plasma 0.991065
ESX1 ESX homeobox 1 0.983057
IGSF3 immunoglobulin superfamily, member 3 0.968341
FUCA1 fucosidase, alpha-L- 1, tissue 0.865093
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 0.86059
IGF1 insulin-like growth factor 1 (somatomedin C) 0.848716
ITM2A integral membrane protein 2A 0.84544
DLX3 distal-less homeobox 3 0.816745
PLEK2 pleckstrin 2 0.797872
FLT1 fms-related tyrosine kinase 1 0.779432
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.773705
PSG9 pregnancy specific beta-1-glycoprotein 9 0.753713
INS insulin 0.728952
BNC2 basonuclin 2 0.723694
DUSP9 dual specificity phosphatase 9 0.714811
HPCAL1 hippocalcin-like 1 0.714005
MATN1 matrilin 1, cartilage matrix protein 0.705547
MNX1 motor neuron and pancreas homeobox 1 0.699919
MAMLD1 mastermind-like domain containing 1 0.696707
HLX H2.0-like homeobox 0.675112
G6PC glucose-6-phosphatase, catalytic subunit 0.674315
IGF2R insulin-like growth factor 2 receptor 0.66755
UTF1 undifferentiated embryonic cell transcription factor 1 0.647348
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.646165
SLC38A1 solute carrier family 38, member 1 0.631598
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.628457
FOSL2 FOS-like antigen 2 0.618268
HOXB6 homeobox B6 0.617486
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.609666
SLC38A2 solute carrier family 38, member 2 0.605372
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.604201
TH tyrosine hydroxylase 0.596402
PGF placental growth factor 0.592116
APOH apolipoprotein H (beta-2-glycoprotein I) 0.578883
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.577327
LEP leptin 0.566443
DRAM1 DNA-damage regulated autophagy modulator 1 0.566443
ASCL2 achaete-scute family bHLH transcription factor 2 0.535022
IGFBP1 insulin-like growth factor binding protein 1 0.534248
FAM132A family with sequence similarity 132, member A 0.523045
ALPP alkaline phosphatase, placental 0.513802
FGFBP1 fibroblast growth factor binding protein 1 0.512264
ALPPL2 alkaline phosphatase, placental-like 2 0.511112
ALPL alkaline phosphatase, liver/bone/kidney 0.510344
DLX4 distal-less homeobox 4 0.509576
HOXA4 homeobox A4 0.502675
PROK1 prokineticin 1 0.501909
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.500761
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.498085
AFP alpha-fetoprotein 0.493503
RBM15 RNA binding motif protein 15 0.48893
ANGPT2 angiopoietin 2 0.487027
BRD2 bromodomain containing 2 0.483224
PFKL phosphofructokinase, liver 0.476014
F2R coagulation factor II (thrombin) receptor 0.474498
DCTD dCMP deaminase 0.471846
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.470711
MED1 mediator complex subunit 1 0.470332
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.470332
F5 coagulation factor V (proaccelerin, labile factor) 0.469576
MIRLET7D microRNA let-7d 0.467684
PIR pirin (iron-binding nuclear protein) 0.46466
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.464283
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.461639
PRSS8 protease, serine, 8 0.451831
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.448064
LGALS13 lectin, galactoside-binding, soluble, 13 0.442795
LIPE lipase, hormone-sensitive 0.43941
ULBP2 UL16 binding protein 2 0.438282
SOCS5 suppressor of cytokine signaling 5 0.434148
GLS2 glutaminase 2 (liver, mitochondrial) 0.431519
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.430393
TEK TEK tyrosine kinase, endothelial 0.416521
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 0.405305
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.404557
MOGS mannosyl-oligosaccharide glucosidase 0.397471
CDC37 cell division cycle 37 0.396353
BDNF brain-derived neurotrophic factor 0.39598
RGS5 regulator of G-protein signaling 5 0.377031
CSAD cysteine sulfinic acid decarboxylase 0.371107
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.370737
RAB3D RAB3D, member RAS oncogene family 0.370737
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.365562
IRAK3 interleukin-1 receptor-associated kinase 3 0.361502
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.356709
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.355604
NRF1 nuclear respiratory factor 1 0.347511
EDN2 endothelin 2 0.340906
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.340539
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.339073
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.339073
TSPY10 testis specific protein, Y-linked 10 0.337608
TSPY3 testis specific protein, Y-linked 3 0.337608
SOCS3 suppressor of cytokine signaling 3 0.333949
HOXB7 homeobox B7 0.333218
F3 coagulation factor III (thromboplastin, tissue factor) 0.331025
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.331025
LAMP1 lysosomal-associated membrane protein 1 0.326281
F2 coagulation factor II (thrombin) 0.324458
SLC22A18 solute carrier family 22, member 18 0.30848
NEUROD1 neuronal differentiation 1 0.306672
CDX1 caudal type homeobox 1 0.302698
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.299812
RNF112 ring finger protein 112 0.294413
CPSF3L cleavage and polyadenylation specific factor 3-like 0.289386
NOS3 nitric oxide synthase 3 (endothelial cell) 0.28831
ACE2 angiotensin I converting enzyme 2 0.285802
PRDM1 PR domain containing 1, with ZNF domain 0.275801
SRPX2 sushi-repeat containing protein, X-linked 2 0.263368
FGR FGR proto-oncogene, Src family tyrosine kinase 0.260891
EPAS1 endothelial PAS domain protein 1 0.260184
KRT18 keratin 18, type I 0.250663
CFI complement factor I 0.250663
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 0.24715
PTHLH parathyroid hormone-like hormone 0.244696
FOXO1 forkhead box O1 0.237706
ASPH aspartate beta-hydroxylase 0.232142
AGA aspartylglucosaminidase 0.227988
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.212608
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.208914
BECN1 beclin 1, autophagy related 0.201962
IGFBP3 insulin-like growth factor binding protein 3 0.200656
CFLAR CASP8 and FADD-like apoptosis regulator 0.199681
FGF10 fibroblast growth factor 10 0.196779
PDX1 pancreatic and duodenal homeobox 1 0.194232
CPN1 carboxypeptidase N, polypeptide 1 0.182957
SRY sex determining region Y 0.182957
PPARG peroxisome proliferator-activated receptor gamma 0.182086
PROCR protein C receptor, endothelial 0.180367
TNNT2 troponin T type 2 (cardiac) 0.175411
GAS6 growth arrest-specific 6 0.172799
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.172291
PLIN1 perilipin 1 0.169571
ACE angiotensin I converting enzyme 0.168617
FBP1 fructose-1,6-bisphosphatase 1 0.168381
ADK adenosine kinase 0.166995
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.166768
REN renin 0.166544
CCNB1 cyclin B1 0.165655
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.163317
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.162306
MBP myelin basic protein 0.158605