| Dataset | GO Biological Process Annotations 2015 |
| Category | structural or functional annotations |
| Type | biological process |
| Description | A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. (Gene Ontology, GO_0002353) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0002353 |
| Similar Terms | |
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2 genes participating in the plasma kallikrein-kinin cascade biological process from the curated GO Biological Process Annotations 2015 dataset.
