plastid-encoded plastid RNA polymerase complex A Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex. (Gene Ontology, GO_0000343)
External Link http://amigo.geneontology.org/amigo/term/GO:0000343
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Genes

614 proteins co-occuring with the plastid-encoded plastid RNA polymerase complex A cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 2.619
ANPEP alanyl (membrane) aminopeptidase 2.562
PGC progastricsin (pepsinogen C) 2.52
PEPD peptidase D 2.462
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.401
ENPEP glutamyl aminopeptidase (aminopeptidase A) 2.285
CTSD cathepsin D 2.201
PGM2 phosphoglucomutase 2 2.025
PGM1 phosphoglucomutase 1 2.022
PGA4 pepsinogen 4, group I (pepsinogen A) 1.982
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 1.974
PGA3 pepsinogen 3, group I (pepsinogen A) 1.895
CTSS cathepsin S 1.891
GRN granulin 1.871
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.862
DAZAP2 DAZ associated protein 2 1.818
CTSB cathepsin B 1.789
DNPEP aspartyl aminopeptidase 1.77
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 1.723
FBF1 Fas (TNFRSF6) binding factor 1 1.713
HTRA1 HtrA serine peptidase 1 1.704
LAMP1 lysosomal-associated membrane protein 1 1.695
GRIA4 glutamate receptor, ionotropic, AMPA 4 1.688
PGA5 pepsinogen 5, group I (pepsinogen A) 1.67
ARX aristaless related homeobox 1.667
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 1.659
PGPEP1 pyroglutamyl-peptidase I 1.65
PGM3 phosphoglucomutase 3 1.646
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.619
SQSTM1 sequestosome 1 1.609
ATG7 autophagy related 7 1.587
TMSB10 thymosin beta 10 1.581
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.56
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.557
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.547
CTSE cathepsin E 1.544
GLO1 glyoxalase I 1.534
CTSL cathepsin L 1.527
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.526
PTBP2 polypyrimidine tract binding protein 2 1.518
AGBL2 ATP/GTP binding protein-like 2 1.513
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 1.51
DERA deoxyribose-phosphate aldolase (putative) 1.503
RNF183 ring finger protein 183 1.499
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.496
BECN1 beclin 1, autophagy related 1.494
SLPI secretory leukocyte peptidase inhibitor 1.475
ANXA5 annexin A5 1.46
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 1.448
CELA3A chymotrypsin-like elastase family, member 3A 1.445
ATG5 autophagy related 5 1.419
MAST4 microtubule associated serine/threonine kinase family member 4 1.405
PDF peptide deformylase (mitochondrial) 1.394
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 1.391
MAP1S microtubule-associated protein 1S 1.382
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.367
MMRN2 multimerin 2 1.357
METAP1 methionyl aminopeptidase 1 1.353
HSPE1 heat shock 10kDa protein 1 1.348
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.334
PROC protein C (inactivator of coagulation factors Va and VIIIa) 1.326
GSR glutathione reductase 1.318
PXDNL peroxidasin-like 1.313
PXDN peroxidasin 1.312
GNPDA1 glucosamine-6-phosphate deaminase 1 1.309
B2M beta-2-microglobulin 1.305
CTNS cystinosin, lysosomal cystine transporter 1.301
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 1.3
GLMN glomulin, FKBP associated protein 1.29
LARS1 leucyl-tRNA synthetase 1 1.28
ULK1 unc-51 like autophagy activating kinase 1 1.275
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.272
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.267
NALF2 NALCN channel auxiliary factor 2 1.263
PPY pancreatic polypeptide 1.262
DSPP dentin sialophosphoprotein 1.248
INS insulin 1.245
RBM46 RNA binding motif protein 46 1.23
MAP1B microtubule-associated protein 1B 1.227
IFNG interferon, gamma 1.227
TYRP1 tyrosinase-related protein 1 1.225
COPS2 COP9 signalosome subunit 2 1.222
FUCA1 fucosidase, alpha-L- 1, tissue 1.212
CCNQ cyclin Q 1.203
HCRTR1 hypocretin (orexin) receptor 1 1.202
MFSD6 major facilitator superfamily domain containing 6 1.191
CTTNBP2 cortactin binding protein 2 1.187
EPHA2 EPH receptor A2 1.187
TBX22 T-box 22 1.187
UBL4A ubiquitin-like 4A 1.18
NOA1 nitric oxide associated 1 1.179
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.179
AMY2B amylase, alpha 2B (pancreatic) 1.178
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 1.177
HEMK1 HemK methyltransferase family member 1 1.175
AMY2A amylase, alpha 2A (pancreatic) 1.175
TNF tumor necrosis factor 1.171
VCX3A variable charge, X-linked 3A 1.166
CTRB1 chymotrypsinogen B1 1.163
GRIK5 glutamate receptor, ionotropic, kainate 5 1.161
HCRT hypocretin (orexin) neuropeptide precursor 1.158
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 1.153
SEBOX SEBOX homeobox 1.15
AMY1B amylase, alpha 1B (salivary) 1.148
MLKL mixed lineage kinase domain-like 1.142
CTRB2 chymotrypsinogen B2 1.141
CD4 CD4 molecule 1.138
NCOA4 nuclear receptor coactivator 4 1.138
CD8A CD8a molecule 1.136
NBR1 neighbor of BRCA1 gene 1 1.136
APP amyloid beta (A4) precursor protein 1.121
UCK2 uridine-cytidine kinase 2 1.089
OPTC opticin 1.087
LAMP2 lysosomal-associated membrane protein 2 1.087
GALE UDP-galactose-4-epimerase 1.084
NPS neuropeptide S 1.083
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 1.083
NEGR1 neuronal growth regulator 1 1.077
CTRL chymotrypsin-like 1.071
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 1.069
CPB1 carboxypeptidase B1 (tissue) 1.062
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.051
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.051
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.045
CYCS cytochrome c, somatic 1.043
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.041
SOD1 superoxide dismutase 1, soluble 1.035
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 1.03
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 1.03
PRTN3 proteinase 3 1.028
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.026
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 1.019
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 1.012
GGT6 gamma-glutamyltransferase 6 1.011
PCSK1 proprotein convertase subtilisin/kexin type 1 1.011
DPP4 dipeptidyl-peptidase 4 1.01
PRTG protogenin 1.01
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 1.008
YME1L1 YME1-like 1 ATPase 1.007
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 1.007
MMP2 matrix metallopeptidase 2 1.005
TPI1 triosephosphate isomerase 1 1.003
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 1.001
PFAS phosphoribosylformylglycinamidine synthase 0.997
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.99
TBL1X transducin (beta)-like 1X-linked 0.99
YBX3 Y box binding protein 3 0.975
SMLR1 small leucine-rich protein 1 0.974
CD274 CD274 molecule 0.973
GABARAPL1 GABA(A) receptor-associated protein like 1 0.968
FLG2 filaggrin family member 2 0.964
LHB luteinizing hormone beta polypeptide 0.962
AMBP alpha-1-microglobulin/bikunin precursor 0.962
FLG filaggrin 0.961
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.961
MGAM maltase-glucoamylase 0.96
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.958
BHMT2 betaine--homocysteine S-methyltransferase 2 0.957
SART1 squamous cell carcinoma antigen recognized by T cells 0.957
PRODH proline dehydrogenase (oxidase) 1 0.956
SEC14L3 SEC14-like 3 (S. cerevisiae) 0.955
ZC3H12D zinc finger CCCH-type containing 12D 0.953
ERBB2 erb-b2 receptor tyrosine kinase 2 0.952
NUBP2 nucleotide binding protein 2 0.951
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.949
TMEM192 transmembrane protein 192 0.948
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.947
ZFHX2 zinc finger homeobox 2 0.945
SEPHS1 selenophosphate synthetase 1 0.945
NT5C 5', 3'-nucleotidase, cytosolic 0.945
ATG14 autophagy related 14 0.944
XYLB xylulokinase homolog (H. influenzae) 0.942
CLSTN1 calsyntenin 1 0.942
LGALS3 lectin, galactoside-binding, soluble, 3 0.941
CCNY cyclin Y 0.94
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.937
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.937
ADCY8 adenylate cyclase 8 (brain) 0.935
LOX lysyl oxidase 0.934
PELI1 pellino E3 ubiquitin protein ligase 1 0.931
HEXB hexosaminidase B (beta polypeptide) 0.93
GGT7 gamma-glutamyltransferase 7 0.929
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.929
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.924
CNIH1 cornichon family AMPA receptor auxiliary protein 1 0.924
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 0.923
CCDC50 coiled-coil domain containing 50 0.922
PRKCSH protein kinase C substrate 80K-H 0.921
FTMT ferritin mitochondrial 0.918
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.917
IL10 interleukin 10 0.917
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.912
RAD51 RAD51 recombinase 0.908
CSN1S1 casein alpha s1 0.907
CFLAR CASP8 and FADD-like apoptosis regulator 0.907
PLG plasminogen 0.905
ATP5IF1 ATP synthase inhibitory factor subunit 1 0.897
DUOXA1 dual oxidase maturation factor 1 0.897
RIPK3 receptor-interacting serine-threonine kinase 3 0.897
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.896
ATG12 autophagy related 12 0.896
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.894
LRRC36 leucine rich repeat containing 36 0.892
FTH1 ferritin, heavy polypeptide 1 0.892
ZNF410 zinc finger protein 410 0.891
SNX5 sorting nexin 5 0.89
CST5 cystatin D 0.888
CIAO2B cytosolic iron-sulfur assembly component 2B 0.887
CPZ carboxypeptidase Z 0.884
WARS1 tryptophanyl-tRNA synthetase 1 0.88
HSPA4 heat shock 70kDa protein 4 0.879
IL6 interleukin 6 0.879
LOC102724560 cystathionine beta-synthase 0.877
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.874
OPRM1 opioid receptor, mu 1 0.871
RAB7A RAB7A, member RAS oncogene family 0.869
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.862
F13B coagulation factor XIII, B polypeptide 0.862
ATG13 autophagy related 13 0.861
EGFR epidermal growth factor receptor 0.859
RRM1 ribonucleotide reductase M1 0.858
BCL2 B-cell CLL/lymphoma 2 0.856
TFEB transcription factor EB 0.855
DUT deoxyuridine triphosphatase 0.853
TALDO1 transaldolase 1 0.852
MOXD1 monooxygenase, DBH-like 1 0.85
CNIH2 cornichon family AMPA receptor auxiliary protein 2 0.849
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.847
PARP1 poly (ADP-ribose) polymerase 1 0.846
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.845
TP53 tumor protein p53 0.844
RBKS ribokinase 0.844
S100A2 S100 calcium binding protein A2 0.842
ASPN asporin 0.84
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.839
EGF epidermal growth factor 0.838
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.836
DIABLO diablo, IAP-binding mitochondrial protein 0.834
DMBT1 deleted in malignant brain tumors 1 0.832
ANXA1 annexin A1 0.831
TTC33 tetratricopeptide repeat domain 33 0.831
IL1B interleukin 1, beta 0.827
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.825
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.824
GDPGP1 GDP-D-glucose phosphorylase 1 0.822
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.822
KLK6 kallikrein-related peptidase 6 0.821
APLF aprataxin and PNKP like factor 0.821
FOS FBJ murine osteosarcoma viral oncogene homolog 0.82
CHD7 chromodomain helicase DNA binding protein 7 0.819
DNAH8 dynein, axonemal, heavy chain 8 0.819
TRO trophinin 0.817
DPP7 dipeptidyl-peptidase 7 0.817
RNF7 ring finger protein 7 0.817
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.815
CHIT1 chitinase 1 (chitotriosidase) 0.811
PGLYRP2 peptidoglycan recognition protein 2 0.809
NPC2 Niemann-Pick disease, type C2 0.809
ESD esterase D 0.808
ESX1 ESX homeobox 1 0.806
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.805
EGLN2 egl-9 family hypoxia-inducible factor 2 0.804
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.804
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.803
AK2 adenylate kinase 2 0.802
PPT1 palmitoyl-protein thioesterase 1 0.801
VDAC1 voltage-dependent anion channel 1 0.799
TRIM32 tripartite motif containing 32 0.799
MIER1 mesoderm induction early response 1, transcriptional regulator 0.798
RPS17 ribosomal protein S17 0.797
C8A complement component 8, alpha polypeptide 0.796
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.796
CBLIF cobalamin binding intrinsic factor 0.794
CNIH4 cornichon family AMPA receptor auxiliary protein 4 0.792
GM2A GM2 ganglioside activator 0.791
CCKAR cholecystokinin A receptor 0.791
HSH2D hematopoietic SH2 domain containing 0.791
CELA3B chymotrypsin-like elastase family, member 3B 0.79
NPTX2 neuronal pentraxin II 0.79
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.79
SELENOI selenoprotein I 0.789
CASP1 caspase 1, apoptosis-related cysteine peptidase 0.789
C5 complement component 5 0.788
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 0.787
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.785
SMOX spermine oxidase 0.782
KCTD11 potassium channel tetramerization domain containing 11 0.782
PRKN parkin RBR E3 ubiquitin protein ligase 0.781
MB myoglobin 0.781
BDNF brain-derived neurotrophic factor 0.78
ENO1 enolase 1, (alpha) 0.78
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.78
M6PR mannose-6-phosphate receptor (cation dependent) 0.779
HBB hemoglobin, beta 0.779
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.778
ZNF521 zinc finger protein 521 0.778
UCK1 uridine-cytidine kinase 1 0.772
CLCN5 chloride channel, voltage-sensitive 5 0.771
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.771
TPH1 tryptophan hydroxylase 1 0.768
AK1 adenylate kinase 1 0.767
COPS3 COP9 signalosome subunit 3 0.766
GALM galactose mutarotase (aldose 1-epimerase) 0.763
ACP3 acid phosphatase 3 0.761
SLC45A3 solute carrier family 45, member 3 0.761
IL2 interleukin 2 0.759
CLN5 ceroid-lipofuscinosis, neuronal 5 0.757
XAGE1A X antigen family member 1A 0.757
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.756
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.754
GPR15 G protein-coupled receptor 15 0.754
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 0.752
ADSL adenylosuccinate lyase 0.751
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 0.751
NOCT nocturnin 0.75
UCKL1 uridine-cytidine kinase 1-like 1 0.749
ACSF2 acyl-CoA synthetase family member 2 0.748
RAB5A RAB5A, member RAS oncogene family 0.748
AARS1 alanyl-tRNA synthetase 1 0.746
FAM184A family with sequence similarity 184, member A 0.746
GUSB glucuronidase, beta 0.746
QDPR quinoid dihydropteridine reductase 0.743
STRADA STE20-related kinase adaptor alpha 0.743
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 0.742
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.741
RB1CC1 RB1-inducible coiled-coil 1 0.74
SYNJ2BP synaptojanin 2 binding protein 0.74
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 0.738
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.738
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.738
SNX6 sorting nexin 6 0.736
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.736
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.736
PELI3 pellino E3 ubiquitin protein ligase family member 3 0.73
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.729
FTL ferritin, light polypeptide 0.727
CDK16 cyclin-dependent kinase 16 0.727
SCGB1D2 secretoglobin, family 1D, member 2 0.727
GAST gastrin 0.726
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.726
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.725
TXN2 thioredoxin 2 0.721
THOP1 thimet oligopeptidase 1 0.721
PRNP prion protein 0.716
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.714
RGMA repulsive guidance molecule family member a 0.714
PRSS58 protease, serine, 58 0.712
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.711
TFRC transferrin receptor 0.71
LIPF lipase, gastric 0.71
SORD sorbitol dehydrogenase 0.71
UCMA upper zone of growth plate and cartilage matrix associated 0.708
GMDS GDP-mannose 4,6-dehydratase 0.708
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 0.707
DHFR dihydrofolate reductase 0.707
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 0.706
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.706
PACRG PARK2 co-regulated 0.705
ATG101 autophagy related 101 0.702
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.7
CAB39 calcium binding protein 39 0.7
AMBRA1 autophagy/beclin-1 regulator 1 0.698
BAX BCL2-associated X protein 0.698
IFNA1 interferon, alpha 1 0.693
MMP25 matrix metallopeptidase 25 0.692
UGDH UDP-glucose 6-dehydrogenase 0.691
ZFY zinc finger protein, Y-linked 0.69
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.689
NLRP3 NLR family, pyrin domain containing 3 0.689
TEX264 testis expressed 264 0.689
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.688
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.688
NAGA N-acetylgalactosaminidase, alpha- 0.687
GALNS galactosamine (N-acetyl)-6-sulfatase 0.687
CLN3 ceroid-lipofuscinosis, neuronal 3 0.687
NISCH nischarin 0.685
RPS2 ribosomal protein S2 0.684
PRMT3 protein arginine methyltransferase 3 0.684
RCC2 regulator of chromosome condensation 2 0.684
NCS1 neuronal calcium sensor 1 0.682
ADSS2 adenylosuccinate synthase 2 0.68
REXO5 RNA exonuclease 5 0.678
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.678
ZNF175 zinc finger protein 175 0.675
PRDX5 peroxiredoxin 5 0.672
IDE insulin-degrading enzyme 0.672
CD33 CD33 molecule 0.671
ACSL4 acyl-CoA synthetase long-chain family member 4 0.671
SYNRG synergin, gamma 0.669
NFS1 NFS1 cysteine desulfurase 0.669
MAPK3 mitogen-activated protein kinase 3 0.668
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.666
MMP9 matrix metallopeptidase 9 0.664
HLA-A major histocompatibility complex, class I, A 0.664
BACE1 beta-site APP-cleaving enzyme 1 0.663
NRG2 neuregulin 2 0.663
PRL prolactin 0.662
LDHD lactate dehydrogenase D 0.662
POTEF POTE ankyrin domain family, member F 0.66
KLK11 kallikrein-related peptidase 11 0.66
LCN2 lipocalin 2 0.659
LDLR low density lipoprotein receptor 0.659
POU2F3 POU class 2 homeobox 3 0.659
LALBA lactalbumin, alpha- 0.656
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.655
IGBP1 immunoglobulin (CD79A) binding protein 1 0.655
NTS neurotensin 0.653
NAGLU N-acetylglucosaminidase, alpha 0.651
YDJC YdjC homolog (bacterial) 0.65
GCDH glutaryl-CoA dehydrogenase 0.65
H2BC21 H2B clustered histone 21 0.647
IGF2R insulin-like growth factor 2 receptor 0.646
PHF1 PHD finger protein 1 0.645
S100A6 S100 calcium binding protein A6 0.645
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.644
FN1 fibronectin 1 0.644
PCDH8 protocadherin 8 0.644
CTSG cathepsin G 0.643
VCAN versican 0.643
GUK1 guanylate kinase 1 0.643
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.643
ERVW-1 endogenous retrovirus group W, member 1 0.642
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.637
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.637
ESR2 estrogen receptor 2 (ER beta) 0.637
TBK1 TANK-binding kinase 1 0.637
IFNB1 interferon, beta 1, fibroblast 0.635
SMC6 structural maintenance of chromosomes 6 0.634
SNX2 sorting nexin 2 0.633
H1-0 H1.0 linker histone 0.632
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.632
STX17 syntaxin 17 0.631
PEDS1 plasmanylethanolamine desaturase 1 0.629
HLA-B major histocompatibility complex, class I, B 0.628
RIPK2 receptor-interacting serine-threonine kinase 2 0.627
MAPK8 mitogen-activated protein kinase 8 0.627
LACC1 laccase (multicopper oxidoreductase) domain containing 1 0.627
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.627
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.627
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.626
KARS1 lysyl-tRNA synthetase 1 0.626
SCIN scinderin 0.625
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.623
MRI1 methylthioribose-1-phosphate isomerase 1 0.623
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.622
TDO2 tryptophan 2,3-dioxygenase 0.621
ACSBG1 acyl-CoA synthetase bubblegum family member 1 0.62
MCEE methylmalonyl CoA epimerase 0.619
HTRA2 HtrA serine peptidase 2 0.619
PHGDH phosphoglycerate dehydrogenase 0.618
LTF lactotransferrin 0.615
RAB9A RAB9A, member RAS oncogene family 0.615
TRIM5 tripartite motif containing 5 0.614
BACE2 beta-site APP-cleaving enzyme 2 0.614
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.613
KNG1 kininogen 1 0.613
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.613
SOCS4 suppressor of cytokine signaling 4 0.612
NRDC nardilysin convertase 0.611
BIRC5 baculoviral IAP repeat containing 5 0.61
CGAS cyclic GMP-AMP synthase 0.606
HDAC9 histone deacetylase 9 0.605
ACTA1 actin, alpha 1, skeletal muscle 0.604
MPZ myelin protein zero 0.601
AKR1C2 aldo-keto reductase family 1, member C2 0.6
GBA1 glucosylceramidase beta 1 0.6
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 0.599
C1QBP complement component 1, q subcomponent binding protein 0.599
MMP8 matrix metallopeptidase 8 0.599
BDH1 3-hydroxybutyrate dehydrogenase, type 1 0.598
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.598
CDA cytidine deaminase 0.597
IDO1 indoleamine 2,3-dioxygenase 1 0.596
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.595
TLR4 toll-like receptor 4 0.595
PRKCA protein kinase C, alpha 0.595
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.595
ECM1 extracellular matrix protein 1 0.595
AGMAT agmatine ureohydrolase (agmatinase) 0.594
TRIM3 tripartite motif containing 3 0.594
PCDHGA2 protocadherin gamma subfamily A, 2 0.594
CREB1 cAMP responsive element binding protein 1 0.594
DRAM1 DNA-damage regulated autophagy modulator 1 0.593
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.593
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.591
TGFB1 transforming growth factor, beta 1 0.591
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.59
AARS2 alanyl-tRNA synthetase 2, mitochondrial 0.59
CTSZ cathepsin Z 0.589
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 0.588
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.586
TH tyrosine hydroxylase 0.586
CAPN1 calpain 1, (mu/I) large subunit 0.586
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.585
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 0.584
KRT15 keratin 15, type I 0.584
NAPSA napsin A aspartic peptidase 0.582
STK11 serine/threonine kinase 11 0.582
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.581
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.581
FADD Fas (TNFRSF6)-associated via death domain 0.581
ACE angiotensin I converting enzyme 0.58
AGRN agrin 0.58
BCL2L1 BCL2-like 1 0.578
CD300C CD300c molecule 0.578
GPX4 glutathione peroxidase 4 0.578
MYH14 myosin, heavy chain 14, non-muscle 0.577
ENGASE endo-beta-N-acetylglucosaminidase 0.577
OCRL oculocerebrorenal syndrome of Lowe 0.576
GNMT glycine N-methyltransferase 0.575
GP2 glycoprotein 2 (zymogen granule membrane) 0.574
PCDHB16 protocadherin beta 16 0.571
GLUL glutamate-ammonia ligase 0.57
LDHA lactate dehydrogenase A 0.57
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 0.57
PPP4C protein phosphatase 4, catalytic subunit 0.568
ORM2 orosomucoid 2 0.566
PEDS1-UBE2V1 PEDS1-UBE2V1 readthrough 0.566
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.565
UVRAG UV radiation resistance associated 0.565
GABARAP GABA(A) receptor-associated protein 0.564
CA1 carbonic anhydrase I 0.563
GC group-specific component (vitamin D binding protein) 0.562
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.561
CIDEB cell death-inducing DFFA-like effector b 0.559
RHAG Rh-associated glycoprotein 0.558
TLR2 toll-like receptor 2 0.558
SYN3 synapsin III 0.558
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.557
GLRX5 glutaredoxin 5 0.557
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.557
LYZL4 lysozyme-like 4 0.556
ATP5MC3 ATP synthase membrane subunit c locus 3 0.556
CD163 CD163 molecule 0.556
RAB4B RAB4B, member RAS oncogene family 0.555
IL17F interleukin 17F 0.554
AMDHD1 amidohydrolase domain containing 1 0.552
SLC51A solute carrier family 51, alpha subunit 0.552
OAF OAF homolog (Drosophila) 0.552
CSRP1 cysteine and glycine-rich protein 1 0.552
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.552
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.551
VIM vimentin 0.551
GKN1 gastrokine 1 0.55
GOLT1A golgi transport 1A 0.549
PEX13 peroxisomal biogenesis factor 13 0.548
ADCY10 adenylate cyclase 10 (soluble) 0.547
PCBP2 poly(rC) binding protein 2 0.546
SPMIP8 sperm microtubule inner protein 8 0.545
EEF2 eukaryotic translation elongation factor 2 0.544
KLK1 kallikrein 1 0.544
DAGLA diacylglycerol lipase, alpha 0.544
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.543
ANTXR2 anthrax toxin receptor 2 0.543
LY86 lymphocyte antigen 86 0.541
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.541
NPY neuropeptide Y 0.541
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 0.541
CPA6 carboxypeptidase A6 0.54
GRIK1 glutamate receptor, ionotropic, kainate 1 0.54
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.539
SEPTIN2 septin 2 0.539
TUBB2A tubulin, beta 2A class IIa 0.539
UBE4B ubiquitination factor E4B 0.537
PMEL premelanosome protein 0.536
OPRD1 opioid receptor, delta 1 0.536
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.535
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.535
CA9 carbonic anhydrase IX 0.534
CDC37 cell division cycle 37 0.533
CLRN3 clarin 3 0.532
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.532
MAGEA1 melanoma antigen family A1 0.531
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 0.53
ADA adenosine deaminase 0.529
RPL8 ribosomal protein L8 0.528
SLC66A1 solute carrier family 66 member 1 0.528
POMC proopiomelanocortin 0.524
FURIN furin (paired basic amino acid cleaving enzyme) 0.521
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.521
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.52
EEA1 early endosome antigen 1 0.52
MAGED4 melanoma antigen family D4 0.52
MTERF1 mitochondrial transcription termination factor 1 0.519
RPL30 ribosomal protein L30 0.519
AGA aspartylglucosaminidase 0.518
VDAC2 voltage-dependent anion channel 2 0.517
ACO1 aconitase 1, soluble 0.517
ALYREF Aly/REF export factor 0.516
TET1 tet methylcytosine dioxygenase 1 0.516
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.515
PARK7 parkinson protein 7 0.512
GRM7 glutamate receptor, metabotropic 7 0.512
CCDC181 coiled-coil domain containing 181 0.511
MSRA methionine sulfoxide reductase A 0.511
IRF3 interferon regulatory factor 3 0.511
RAB1A RAB1A, member RAS oncogene family 0.511
IAPP islet amyloid polypeptide 0.509
PKN2 protein kinase N2 0.509
CHML choroideremia-like (Rab escort protein 2) 0.508
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.508
C1S complement component 1, s subcomponent 0.508
GSN gelsolin 0.508
TUB tubby bipartite transcription factor 0.506
BRD4 bromodomain containing 4 0.506
GRM5 glutamate receptor, metabotropic 5 0.506
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.504
MGLL monoglyceride lipase 0.504
PASD1 PAS domain containing 1 0.503
VTN vitronectin 0.503
TMEM37 transmembrane protein 37 0.502
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.502
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.502
APOB apolipoprotein B 0.501