platelet alpha granule Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). (Gene Ontology, GO_0031091)
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Genes

75 proteins co-occuring with the platelet alpha granule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PF4 platelet factor 4 2.62166
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.40918
MMRN1 multimerin 1 1.79177
VWF von Willebrand factor 1.53387
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.50283
THBS1 thrombospondin 1 1.37851
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.28569
F5 coagulation factor V (proaccelerin, labile factor) 1.2055
TREML1 triggering receptor expressed on myeloid cells-like 1 0.915776
AZU1 azurocidin 1 0.873186
F2R coagulation factor II (thrombin) receptor 0.764072
PF4V1 platelet factor 4 variant 1 0.734217
RAB6C RAB6C, member RAS oncogene family 0.728389
TGFB1 transforming growth factor, beta 1 0.719906
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.715458
F3 coagulation factor III (thromboplastin, tissue factor) 0.714126
THBD thrombomodulin 0.681591
PLAT plasminogen activator, tissue 0.673328
TTC37 tetratricopeptide repeat domain 37 0.666394
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.630745
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.616285
PLG plasminogen 0.609509
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.60655
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.600223
THPO thrombopoietin 0.593492
F8 coagulation factor VIII, procoagulant component 0.592652
FN1 fibronectin 1 0.584268
PROS1 protein S (alpha) 0.577999
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.528388
COX5A cytochrome c oxidase subunit Va 0.523476
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 0.501476
THBS4 thrombospondin 4 0.494585
CD63 CD63 molecule 0.485289
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.481258
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.454816
CCL17 chemokine (C-C motif) ligand 17 0.446069
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.434985
ESAM endothelial cell adhesion molecule 0.416902
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.403637
APP amyloid beta (A4) precursor protein 0.397811
ALB albumin 0.392388
RFK riboflavin kinase 0.377354
SRGN serglycin 0.371599
SCAMP2 secretory carrier membrane protein 2 0.363949
F2 coagulation factor II (thrombin) 0.356324
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.332472
COL3A1 collagen, type III, alpha 1 0.31783
MPL MPL proto-oncogene, thrombopoietin receptor 0.316708
TBX2 T-box 2 0.309613
EMILIN1 elastin microfibril interfacer 1 0.275936
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.267871
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.257289
LAMA5 laminin, alpha 5 0.251476
CD47 CD47 molecule 0.251476
COMP cartilage oligomeric matrix protein 0.241356
CXCL8 chemokine (C-X-C motif) ligand 8 0.239197
GP6 glycoprotein VI (platelet) 0.237401
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.22385
STX4 syntaxin 4 0.22279
PDGFA platelet-derived growth factor alpha polypeptide 0.209858
NT5C 5', 3'-nucleotidase, cytosolic 0.208481
HRG histidine-rich glycoprotein 0.201335
FAM195A family with sequence similarity 195, member A 0.196999
AQP7 aquaporin 7 0.191777
CCL7 chemokine (C-C motif) ligand 7 0.191456
CD36 CD36 molecule (thrombospondin receptor) 0.188274
CCL22 chemokine (C-C motif) ligand 22 0.170371
APLP2 amyloid beta (A4) precursor-like protein 2 0.170371
PLAU plasminogen activator, urokinase 0.169859
GAS6 growth arrest-specific 6 0.165231
SNAP23 synaptosomal-associated protein, 23kDa 0.160658
ARID1A AT rich interactive domain 1A (SWI-like) 0.160254
IL11 interleukin 11 0.160053
RAB27B RAB27B, member RAS oncogene family 0.159658
LGMN legumain 0.156513
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