pml Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description promyelocytic leukemia|The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5371)
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Genes

80 genes co-occuring with the biological term pml in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AXIN1 axin 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
CASP8AP2 caspase 8 associated protein 2
CCNT1 cyclin T1
CDK9 cyclin-dependent kinase 9
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CIITA class II, major histocompatibility complex, transactivator
COIL coilin
CREBBP CREB binding protein
CSNK1A1 casein kinase 1, alpha 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CXCL10 chemokine (C-X-C motif) ligand 10
DAXX death-domain associated protein
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DIABLO diablo, IAP-binding mitochondrial protein
EGFR epidermal growth factor receptor
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF4E eukaryotic translation initiation factor 4E
ELF4 E74-like factor 4 (ets domain transcription factor)
EP300 E1A binding protein p300
H3F3A H3 histone, family 3A
HDAC7 histone deacetylase 7
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HMBOX1 homeobox containing 1
HSPA8 heat shock 70kDa protein 8
IFNG interferon, gamma
IL6 interleukin 6
KAT6A K(lysine) acetyltransferase 6A
KLHL20 kelch-like family member 20
LYZ lysozyme
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK7 mitogen-activated protein kinase 7
MORC3 MORC family CW-type zinc finger 3
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAWR PRKC, apoptosis, WT1, regulator
PIAS4 protein inhibitor of activated STAT, 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PML promyelocytic leukemia
PRKCD protein kinase C, delta
RAD51 RAD51 recombinase
RARA retinoic acid receptor, alpha
RCOR1 REST corepressor 1
RNF111 ring finger protein 111
RNF4 ring finger protein 4
RPAIN RPA interacting protein
SATB1 SATB homeobox 1
SELL selectin L
SENP6 SUMO1/sentrin specific peptidase 6
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SP100 SP100 nuclear antigen
SPI1 Spi-1 proto-oncogene
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TBX2 T-box 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TNF tumor necrosis factor
TOPBP1 topoisomerase (DNA) II binding protein 1
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WRN Werner syndrome, RecQ helicase-like
YAP1 Yes-associated protein 1
ZFHX3 zinc finger homeobox 3
ZMYM2 zinc finger, MYM-type 2