pneumoconiosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An interstitial lung disease that is caused by the inhalation of dust. (Human Disease Ontology, DOID_10316)
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Genes

303 genes co-occuring with the disease pneumoconiosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 1.81013
FTL ferritin, light polypeptide 1.80066
TF transferrin 1.46539
HFE hemochromatosis 1.36074
TNF tumor necrosis factor 1.21608
SOD2 superoxide dismutase 2, mitochondrial 1.17937
SEC14L3 SEC14-like 3 (S. cerevisiae) 1.12783
TGFB1 transforming growth factor, beta 1 1.11141
CAT catalase 1.0627
ACE angiotensin I converting enzyme 0.991487
FN1 fibronectin 1 0.990222
UROD uroporphyrinogen decarboxylase 0.973801
CP ceruloplasmin (ferroxidase) 0.928346
FASLG Fas ligand (TNF superfamily, member 6) 0.898282
MSLN mesothelin 0.862228
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.859362
IL1B interleukin 1, beta 0.852811
SEC23B Sec23 homolog B (S. cerevisiae) 0.835198
GPX5 glutathione peroxidase 5 0.825768
GPX4 glutathione peroxidase 4 0.822077
GPX1 glutathione peroxidase 1 0.805667
CD4 CD4 molecule 0.783116
TFRC transferrin receptor 0.750864
CD79A CD79a molecule, immunoglobulin-associated alpha 0.749237
RGS14 regulator of G-protein signaling 14 0.735838
MICA MHC class I polypeptide-related sequence A 0.732191
ZBTB32 zinc finger and BTB domain containing 32 0.730976
PRDX1 peroxiredoxin 1 0.701124
NLRP3 NLR family, pyrin domain containing 3 0.685091
CYBRD1 cytochrome b reductase 1 0.666755
MARCO macrophage receptor with collagenous structure 0.656837
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.654858
HAMP hepcidin antimicrobial peptide 0.626103
ACRV1 acrosomal vesicle protein 1 0.619442
MRPL13 mitochondrial ribosomal protein L13 0.612792
ALB albumin 0.612401
SOD3 superoxide dismutase 3, extracellular 0.606933
ALPPL2 alkaline phosphatase, placental-like 2 0.590948
ALPP alkaline phosphatase, placental 0.590558
ALPL alkaline phosphatase, liver/bone/kidney 0.590169
CXCL8 chemokine (C-X-C motif) ligand 8 0.58939
MPO myeloperoxidase 0.587054
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.586665
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.558674
EGR1 early growth response 1 0.524202
IL1RN interleukin 1 receptor antagonist 0.522659
IL6 interleukin 6 0.520731
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.519575
CRP C-reactive protein, pentraxin-related 0.518034
IGF1 insulin-like growth factor 1 (somatomedin C) 0.51534
GSTT1 glutathione S-transferase theta 1 0.508041
GSTTP1 glutathione S-transferase theta pseudogene 1 0.508041
HSPA1L heat shock 70kDa protein 1-like 0.501909
SFTPD surfactant protein D 0.498085
GSTM1 glutathione S-transferase mu 1 0.495411
CCL2 chemokine (C-C motif) ligand 2 0.493885
ACO1 aconitase 1, soluble 0.493122
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.488169
ADAP2 ArfGAP with dual PH domains 2 0.482464
KIF18A kinesin family member 18A 0.476393
BANF1 barrier to autointegration factor 1 0.475255
POMC proopiomelanocortin 0.46655
MMD monocyte to macrophage differentiation-associated 0.46466
IL1A interleukin 1, alpha 0.455601
HEPH hephaestin 0.429642
JUN jun proto-oncogene 0.429642
ELANE elastase, neutrophil expressed 0.42589
LYZ lysozyme 0.423265
FOXD3 forkhead box D3 0.42214
TMX1 thioredoxin-related transmembrane protein 1 0.420641
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.418768
GGT1 gamma-glutamyltransferase 1 0.416147
SUGP1 SURP and G patch domain containing 1 0.41465
TP53 tumor protein p53 0.413901
GUSB glucuronidase, beta 0.410909
SIGLEC7 sialic acid binding Ig-like lectin 7 0.408292
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.408292
HFE2 hemochromatosis type 2 (juvenile) 0.405678
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.401199
CARD17 caspase recruitment domain family, member 17 0.393001
HP haptoglobin 0.391513
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.386308
GLB1 galactosidase, beta 1 0.385936
HPR haptoglobin-related protein 0.385565
C1ORF167 chromosome 1 open reading frame 167 0.378143
TIMP1 TIMP metallopeptidase inhibitor 1 0.37629
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.375179
ACO2 aconitase 2, mitochondrial 0.374809
MMP12 matrix metallopeptidase 12 0.369258
ACPP acid phosphatase, prostate 0.36741
FCMR Fc fragment of IgM receptor 0.366671
YME1L1 YME1-like 1 ATPase 0.365193
TCERG1 transcription elongation regulator 1 0.359657
DSG3 desmoglein 3 0.357446
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.349717
CLEC3B C-type lectin domain family 3, member B 0.344941
PRTN3 proteinase 3 0.342006
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.333218
ELN elastin 0.33066
OGG1 8-oxoguanine DNA glycosylase 0.33066
IL12B interleukin 12B 0.330295
TARS threonyl-tRNA synthetase 0.328105
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.326646
GGT2 gamma-glutamyltransferase 2 0.326646
CD5L CD5 molecule-like 0.324094
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.319363
EGFR epidermal growth factor receptor 0.318999
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 0.316456
B2M beta-2-microglobulin 0.314278
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.312827
C3 complement component 3 0.308842
SRR serine racemase 0.307757
RNASEH2A ribonuclease H2, subunit A 0.307395
FBXO44 F-box protein 44 0.306672
OVGP1 oviductal glycoprotein 1, 120kDa 0.304142
DTNA dystrobrevin, alpha 0.302698
COL1A2 collagen, type I, alpha 2 0.301976
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.298731
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.296571
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.293334
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.284013
SMAD7 SMAD family member 7 0.283297
UROS uroporphyrinogen III synthase 0.28151
FABP9 fatty acid binding protein 9, testis 0.280439
IL17F interleukin 17F 0.27794
LRRC38 leucine rich repeat containing 38 0.273308
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.266203
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.260891
TPM4 tropomyosin 4 0.25877
TRIP10 thyroid hormone receptor interactor 10 0.258064
HLA-A major histocompatibility complex, class I, A 0.255241
GSTA3 glutathione S-transferase alpha 3 0.250311
PGM1 phosphoglucomutase 1 0.24996
GSTA2 glutathione S-transferase alpha 2 0.249257
MMP13 matrix metallopeptidase 13 0.249257
PPT1 palmitoyl-protein thioesterase 1 0.248203
TTR transthyretin 0.248203
GSTA4 glutathione S-transferase alpha 4 0.248203
HAGH hydroxyacylglutathione hydrolase 0.243995
KRT75 keratin 75, type II 0.243645
GSTA1 glutathione S-transferase alpha 1 0.242595
PAM peptidylglycine alpha-amidating monooxygenase 0.241196
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.239101
CPM carboxypeptidase M 0.232142
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.230755
SPP1 secreted phosphoprotein 1 0.228333
WRNIP1 Werner helicase interacting protein 1 0.227297
GLO1 glyoxalase I 0.225573
IGLV9-49 immunoglobulin lambda variable 9-49 0.223165
GPX3 glutathione peroxidase 3 0.222822
HMOX1 heme oxygenase 1 0.220766
COL3A1 collagen, type III, alpha 1 0.211934
SUMO1 small ubiquitin-like modifier 1 0.211934
IGLV5-48 immunoglobulin lambda variable 5-48 (non-functional) 0.205254
HLA-C major histocompatibility complex, class I, C 0.204593
PIDD1 p53-induced death domain protein 1 0.202946
ISCU iron-sulfur cluster assembly enzyme 0.200331
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.19742
IL2RA interleukin 2 receptor, alpha 0.192344
AURKAIP1 aurora kinase A interacting protein 1 0.189859
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.18591
DUSP3 dual specificity phosphatase 3 0.183541
ENO2 enolase 2 (gamma, neuronal) 0.182666
TFR2 transferrin receptor 2 0.182086
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.180367
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.178126
DSG1 desmoglein 1 0.178126
DLAT dihydrolipoamide S-acetyltransferase 0.177851
IL18R1 interleukin 18 receptor 1 0.176215
CFD complement factor D (adipsin) 0.175947
MAPK7 mitogen-activated protein kinase 7 0.175411
ESPN espin 0.174617
ALYREF Aly/REF export factor 0.170789
MINK1 misshapen-like kinase 1 0.170054
CCL3 chemokine (C-C motif) ligand 3 0.169571
CDKN2A cyclin-dependent kinase inhibitor 2A 0.16933
NT5E 5'-nucleotidase, ecto (CD73) 0.169091
LRG1 leucine-rich alpha-2-glycoprotein 1 0.164786
CHIT1 chitinase 1 (chitotriosidase) 0.164149
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.160761
CARD8 caspase recruitment domain family, member 8 0.160574
PDS5B PDS5 cohesin associated factor B 0.160021
NLRC4 NLR family, CARD domain containing 4 0.159838
CFB complement factor B 0.159658
CTSE cathepsin E 0.159124
SIX1 SIX homeobox 1 0.138382
PER3 period circadian clock 3 0.131297
TFDP3 transcription factor Dp family, member 3 0.129828
CPB2 carboxypeptidase B2 (plasma) 0.126684
HAS1 hyaluronan synthase 1 0.126228
HLA-DMA major histocompatibility complex, class II, DM alpha 0.126145
FOXP3 forkhead box P3 0.122081
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.122081
CTSA cathepsin A 0.117432
PLA2G1B phospholipase A2, group IB (pancreas) 0.116426
CALB2 calbindin 2 0.115111
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.11458
KIF5A kinesin family member 5A 0.11448
MEFV Mediterranean fever 0.113836
TSPO translocator protein (18kDa) 0.111723
MRAP melanocortin 2 receptor accessory protein 0.111642
MIR222 microRNA 222 0.110877
DGUOK deoxyguanosine kinase 0.110738
C5AR1 complement component 5a receptor 1 0.110319
ADCY2 adenylate cyclase 2 (brain) 0.110096
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.110096
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.109464
RER1 retention in endoplasmic reticulum sorting receptor 1 0.109177
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.108559
PDIA3 protein disulfide isomerase family A, member 3 0.108471
CCL15 chemokine (C-C motif) ligand 15 0.108353
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.108117
FXYD1 FXYD domain containing ion transport regulator 1 0.108058
IL2 interleukin 2 0.107633
KMT2A lysine (K)-specific methyltransferase 2A 0.10739
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.107208
HPGDS hematopoietic prostaglandin D synthase 0.106403
CPOX coproporphyrinogen oxidase 0.105936
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.105904
DUSP6 dual specificity phosphatase 6 0.105584
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.105072
TGFA transforming growth factor, alpha 0.104944
PATE1 prostate and testis expressed 1 0.104554
RETNLB resistin like beta 0.104259
KRT37 keratin 37, type I 0.103964
ICAM3 intercellular adhesion molecule 3 0.103832
SRRM1 serine/arginine repetitive matrix 1 0.10313
WNT2 wingless-type MMTV integration site family member 2 0.102794
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.102693
KNG1 kininogen 1 0.10266
DPT dermatopontin 0.102626
GC group-specific component (vitamin D binding protein) 0.102354
ALAS1 5'-aminolevulinate synthase 1 0.10225
CTSK cathepsin K 0.101906
PCNA proliferating cell nuclear antigen 0.101039
SCARB2 scavenger receptor class B, member 2 0.100968
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.100898
CD69 CD69 molecule 0.10051
CHIA chitinase, acidic 0.099871
TGFB2 transforming growth factor, beta 2 0.099762
CD36 CD36 molecule (thrombospondin receptor) 0.099474
ALAS2 5'-aminolevulinate synthase 2 0.099257
DNAH8 dynein, axonemal, heavy chain 8 0.098715
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.098641
MIR210 microRNA 210 0.097829
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.097682
NCR1 natural cytotoxicity triggering receptor 1 0.097682
MIR146A microRNA 146a 0.097608
CCL24 chemokine (C-C motif) ligand 24 0.097234
ODC1 ornithine decarboxylase 1 0.097083
CD86 CD86 molecule 0.096894
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.096706
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.096631
WIPF2 WAS/WASL interacting protein family, member 2 0.096367
CTSD cathepsin D 0.096367
SRPX2 sushi-repeat containing protein, X-linked 2 0.096217
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.096217
AIM2 absent in melanoma 2 0.095679
KNTC1 kinetochore associated 1 0.095564
ACOT13 acyl-CoA thioesterase 13 0.095487
SCARB1 scavenger receptor class B, member 1 0.095448
CRLF1 cytokine receptor-like factor 1 0.095295
CTSH cathepsin H 0.095295
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.095026
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.094559
CLDN3 claudin 3 0.094402
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.093261
IL9 interleukin 9 0.093221
TXNIP thioredoxin interacting protein 0.092862
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.092702
WDR11 WD repeat domain 11 0.092542
HCRT hypocretin (orexin) neuropeptide precursor 0.092383
FGF2 fibroblast growth factor 2 (basic) 0.091778
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.090965
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.090884
MMP2 matrix metallopeptidase 2 0.090722
GAL galanin/GMAP prepropeptide 0.090557
HSPA4 heat shock 70kDa protein 4 0.090226
SELE selectin E 0.090102
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.090061
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.08973
ERN1 endoplasmic reticulum to nucleus signaling 1 0.089689
NF2 neurofibromin 2 (merlin) 0.089565
TOP1 topoisomerase (DNA) I 0.089358
PDGFB platelet-derived growth factor beta polypeptide 0.089234
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.088436
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.088352
EDA ectodysplasin A 0.088268
NELFCD negative elongation factor complex member C/D 0.088184
ANXA5 annexin A5 0.087932
PTCH1 patched 1 0.08789
CA8 carbonic anhydrase VIII 0.087848
CLDN4 claudin 4 0.087294
IL7R interleukin 7 receptor 0.087294
CD68 CD68 molecule 0.087038
GSTP1 glutathione S-transferase pi 1 0.086868
MAPK9 mitogen-activated protein kinase 9 0.086357
CSTB cystatin B (stefin B) 0.086228
EPB41 erythrocyte membrane protein band 4.1 0.085838
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.085838
SFTPC surfactant protein C 0.085492
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.085492
CTSS cathepsin S 0.085276