podophyllotoxin-2540 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the podophyllotoxin-2540 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACVR1 activin A receptor, type I
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ANXA2 annexin A2
ANXA2P2 annexin A2 pseudogene 2
APAF1 apoptotic peptidase activating factor 1
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATXN1 ataxin 1
AXL AXL receptor tyrosine kinase
B9D2 B9 protein domain 2
BAIAP2 BAI1-associated protein 2
BCL3 B-cell CLL/lymphoma 3
BMP6 bone morphogenetic protein 6
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAPN2 calpain 2, (m/II) large subunit
CCDC69 coiled-coil domain containing 69
CCL20 chemokine (C-C motif) ligand 20
CCL22 chemokine (C-C motif) ligand 22
CCNG2 cyclin G2
CD38 CD38 molecule
CD86 CD86 molecule
CDC14A cell division cycle 14A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLDND1 claudin domain containing 1
COL9A3 collagen, type IX, alpha 3
CREM cAMP responsive element modulator
CYHR1 cysteine/histidine-rich 1
DFNA5 deafness, autosomal dominant 5
DNMBP dynamin binding protein
DOCK4 dedicator of cytokinesis 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP8 dual specificity phosphatase 8
EPAS1 endothelial PAS domain protein 1
FAM114A1 family with sequence similarity 114, member A1
FLOT1 flotillin 1
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GK glycerol kinase
GLIPR1 GLI pathogenesis-related 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR183 G protein-coupled receptor 183
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL10RA interleukin 10 receptor, alpha
IL1RN interleukin 1 receptor antagonist
ING4 inhibitor of growth family, member 4
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB5 integrin, beta 5
JOSD1 Josephin domain containing 1
KLF6 Kruppel-like factor 6
KYNU kynureninase
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LPP LIM domain containing preferred translocation partner in lipoma
MCAM melanoma cell adhesion molecule
MCTP2 multiple C2 domains, transmembrane 2
MIR22HG MIR22 host gene
MXD4 MAX dimerization protein 4
NCOA3 nuclear receptor coactivator 3
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PLK4 polo-like kinase 4
PLSCR1 phospholipid scramblase 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PTBP3 polypyrimidine tract binding protein 3
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRO protein tyrosine phosphatase, receptor type, O
RAB8B RAB8B, member RAS oncogene family
RBM47 RNA binding motif protein 47
RHOB ras homolog family member B
RIT1 Ras-like without CAAX 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM242 transmembrane protein 242
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM4 tropomyosin 4
TRPS1 trichorhinophalangeal syndrome I
TUBB2A tubulin, beta 2A class IIa
WDR1 WD repeat domain 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAM15 ADAM metallopeptidase domain 15
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRA3 adhesion G protein-coupled receptor A3
ANKRD55 ankyrin repeat domain 55
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARRB1 arrestin, beta 1
ARSB arylsulfatase B
C10ORF2 chromosome 10 open reading frame 2
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CARD9 caspase recruitment domain family, member 9
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CDHR2 cadherin-related family member 2
CDK20 cyclin-dependent kinase 20
CDON cell adhesion associated, oncogene regulated
CECR1 cat eye syndrome chromosome region, candidate 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST10 carbohydrate sulfotransferase 10
COA7 cytochrome c oxidase assembly factor 7 (putative)
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDN dendrin
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DPH2 DPH2 homolog (S. cerevisiae)
DPY19L2P2 DPY19L2 pseudogene 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
FAM13C family with sequence similarity 13, member C
FAM86B1 family with sequence similarity 86, member B1
FAM86C1 family with sequence similarity 86, member C1
FGF23 fibroblast growth factor 23
FJX1 four jointed box 1 (Drosophila)
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMPD1 FERM and PDZ domain containing 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAMP hepcidin antimicrobial peptide
HCG4 HLA complex group 4 (non-protein coding)
HSPA4L heat shock 70kDa protein 4-like
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INO80D INO80 complex subunit D
KAT2A K(lysine) acetyltransferase 2A
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
LPPR3 lipid phosphate phosphatase-related protein type 3
MAK16 MAK16 homolog (S. cerevisiae)
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCM3AP-AS1 MCM3AP antisense RNA 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMB neuromedin B
NNAT neuronatin
NOL6 nucleolar protein 6 (RNA-associated)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTHL1 nth endonuclease III-like 1 (E. coli)
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PES1 pescadillo ribosomal biogenesis factor 1
PFAS phosphoribosylformylglycinamidine synthase
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PODXL2 podocalyxin-like 2
PPAN peter pan homolog (Drosophila)
PPAT phosphoribosyl pyrophosphate amidotransferase
PRDM13 PR domain containing 13
PTGES2 prostaglandin E synthase 2
PTRH2 peptidyl-tRNA hydrolase 2
PUS7 pseudouridylate synthase 7 (putative)
RHOBTB2 Rho-related BTB domain containing 2
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SDF2L1 stromal cell-derived factor 2-like 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC16A6 solute carrier family 16, member 6
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STEAP3 STEAP family member 3, metalloreductase
STRA13 stimulated by retinoic acid 13
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TEC tec protein tyrosine kinase
TERT telomerase reverse transcriptase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM212 transmembrane protein 212
UNG uracil-DNA glycosylase
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
ZC4H2 zinc finger, C4H2 domain containing
ZNF696 zinc finger protein 696
ZNF768 zinc finger protein 768