podosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. (Gene Ontology, GO_0002102)
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Genes

162 proteins co-occuring with the podosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CTTN cortactin 1.86899
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.85182
WAS Wiskott-Aldrich syndrome 1.64374
SH3PXD2B SH3 and PX domains 2B 1.62
SH3PXD2A SH3 and PX domains 2A 1.45647
VCL vinculin 1.34828
PXN paxillin 1.22516
AFAP1 actin filament associated protein 1 1.08679
RHOU ras homolog family member U 1.07917
CDC42 cell division cycle 42 1.05488
HCK HCK proto-oncogene, Src family tyrosine kinase 1.0413
GSN gelsolin 1.01833
PTPRE protein tyrosine phosphatase, receptor type, E 0.917644
PALLD palladin, cytoskeletal associated protein 0.895794
LPXN leupaxin 0.886551
SVIL supervillin 0.854798
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.852042
CALD1 caldesmon 1 0.844237
RHOF ras homolog family member F (in filopodia) 0.804772
AFAP1L1 actin filament associated protein 1-like 1 0.803855
CD302 CD302 molecule 0.787359
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.764072
FSCN1 fascin actin-bundling protein 1 0.741867
FN1 fibronectin 1 0.724365
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.712351
FGD6 FYVE, RhoGEF and PH domain containing 6 0.688139
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.687264
SEBOX SEBOX homeobox 0.677238
AFAP1L2 actin filament associated protein 1-like 2 0.672026
SPP1 secreted phosphoprotein 1 0.662503
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.646574
WASL Wiskott-Aldrich syndrome-like 0.635013
ZYX zyxin 0.632878
FNBP1 formin binding protein 1 0.627335
CCL19 chemokine (C-C motif) ligand 19 0.62393
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.617557
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.612048
PLS1 plastin 1 0.593492
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.591812
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.590553
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.577999
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.575912
BCAR1 breast cancer anti-estrogen resistance 1 0.572162
ARHGAP35 Rho GTPase activating protein 35 0.567585
SH3GL1 SH3-domain GRB2-like 1 0.561358
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 0.555145
MMP9 matrix metallopeptidase 9 0.553078
TAGLN transgelin 0.548535
CLCN7 chloride channel, voltage-sensitive 7 0.545648
CSF1 colony stimulating factor 1 (macrophage) 0.544411
FERMT3 fermitin family member 3 0.535361
PVRL3 poliovirus receptor-related 3 0.526341
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.525931
CTSK cathepsin K 0.521841
RHOBTB1 Rho-related BTB domain containing 1 0.513677
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 0.512862
GRB2 growth factor receptor-bound protein 2 0.508383
OCSTAMP osteoclast stimulatory transmembrane protein 0.498231
HDAC6 histone deacetylase 6 0.498231
VASP vasodilator-stimulated phosphoprotein 0.49742
ARHGAP18 Rho GTPase activating protein 18 0.497015
CCL21 chemokine (C-C motif) ligand 21 0.495395
STARD13 StAR-related lipid transfer (START) domain containing 13 0.49499
DOCK5 dedicator of cytokinesis 5 0.484886
MMP2 matrix metallopeptidase 2 0.48287
ARHGAP1 Rho GTPase activating protein 1 0.475625
FLNA filamin A, alpha 0.459203
NCK1 NCK adaptor protein 1 0.454816
AKAP12 A kinase (PRKA) anchor protein 12 0.450836
CSK c-src tyrosine kinase 0.446069
DCSTAMP dendrocyte expressed seven transmembrane protein 0.432618
CSF1R colony stimulating factor 1 receptor 0.432618
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.425924
CCR7 chemokine (C-C motif) receptor 7 0.424745
MIR4315-2 microRNA 4315-2 0.419252
MIR4315-1 microRNA 4315-1 0.419252
DNM2 dynamin 2 0.418468
KIF9 kinesin family member 9 0.416902
SPATA13 spermatogenesis associated 13 0.415337
NET1 neuroepithelial cell transforming 1 0.407919
LPAR3 lysophosphatidic acid receptor 3 0.404415
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.403248
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.399751
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 0.391615
AMOTL2 angiomotin like 2 0.388909
ASB2 ankyrin repeat and SOCS box containing 2 0.388137
MRVI1 murine retrovirus integration site 1 homolog 0.367388
OSBPL3 oxysterol binding protein-like 3 0.365859
TLN1 talin 1 0.363567
NEXN nexilin (F actin binding protein) 0.363567
ACPP acid phosphatase, prostate 0.359752
GCSAM germinal center-associated, signaling and motility 0.358228
EPS8 epidermal growth factor receptor pathway substrate 8 0.357467
DIAPH3 diaphanous-related formin 3 0.354042
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.352142
TRIP10 thyroid hormone receptor interactor 10 0.349863
CNN3 calponin 3, acidic 0.347208
MIR31 microRNA 31 0.34645
WIPF3 WAS/WASL interacting protein family, member 3 0.343421
RHOB ras homolog family member B 0.336619
ARHGAP26 Rho GTPase activating protein 26 0.331719
BAIAP2 BAI1-associated protein 2 0.328332
KIRREL3 kin of IRRE like 3 (Drosophila) 0.323825
BIN2 bridging integrator 2 0.318953
RRAS related RAS viral (r-ras) oncogene homolog 0.31596
ARF6 ADP-ribosylation factor 6 0.31596
TPM1 tropomyosin 1 (alpha) 0.308494
TLN2 talin 2 0.30626
LPAR1 lysophosphatidic acid receptor 1 0.304771
CD44 CD44 molecule (Indian blood group) 0.302168
KIF1C kinesin family member 1C 0.296972
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.291787
ADAM19 ADAM metallopeptidase domain 19 0.290308
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.279612
MMP25 matrix metallopeptidase 25 0.277774
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.275936
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.274835
FGD1 FYVE, RhoGEF and PH domain containing 1 0.268603
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.259837
VCAN versican 0.257652
ARHGAP5 Rho GTPase activating protein 5 0.255834
PFN1 profilin 1 0.255834
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.255834
GAB1 GRB2-associated binding protein 1 0.25438
AMPH amphiphysin 0.254017
FMNL1 formin-like 1 0.252564
CXCL12 chemokine (C-X-C motif) ligand 12 0.252202
LGALS7B lectin, galactoside-binding, soluble, 7B 0.251114
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.250389
ADRBK1 adrenergic, beta, receptor kinase 1 0.246769
EXT2 exostosin glycosyltransferase 2 0.245685
PTPRD protein tyrosine phosphatase, receptor type, D 0.24424
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.237042
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.235966
PTK2B protein tyrosine kinase 2 beta 0.233101
CDKN2A cyclin-dependent kinase inhibitor 2A 0.231672
ACTB actin, beta 0.231672
GDI1 GDP dissociation inhibitor 1 0.230958
DBNL drebrin-like 0.229532
CIB1 calcium and integrin binding 1 (calmyrin) 0.221025
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.220321
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.213322
CALCA calcitonin-related polypeptide alpha 0.21124
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.204718
WDR1 WD repeat domain 1 0.203022
GDF2 growth differentiation factor 2 0.200328
ILK integrin-linked kinase 0.198658
PLEK pleckstrin 0.193719
PTPRA protein tyrosine phosphatase, receptor type, A 0.190495
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.184853
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.18093
MYO9B myosin IXB 0.178299
DCT dopachrome tautomerase 0.174087
MIR145 microRNA 145 0.173814
AMBN ameloblastin (enamel matrix protein) 0.17141
STK25 serine/threonine kinase 25 0.170371
ADAM15 ADAM metallopeptidase domain 15 0.169604
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.168101
FLII flightless I homolog (Drosophila) 0.164315
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.160053
LSP1 lymphocyte-specific protein 1 0.159856
PTS 6-pyruvoyltetrahydropterin synthase 0.15776