polymeric IgA immunoglobulin complex Gene Set

Dataset GO Cellular Component Annotations 2023
Category structural or functional annotations
Type biological process
Description A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. (Gene Ontology, GO_0071749)
External Link http://amigo.geneontology.org/amigo/term/GO:0071749
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5 proteins localized to the polymeric IgA immunoglobulin complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

Symbol Name
IGHA1 immunoglobulin heavy constant alpha 1
IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker)
IGKV3-20 immunoglobulin kappa variable 3-20
JCHAIN joining chain of multimeric IgA and IgM
PIGR polymeric immunoglobulin receptor