polyphagia Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat. (Human Phenotype Ontology, HP_0002591)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001433
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Genes

53 gene mutations causing the polyphagia phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADRB3 adrenoceptor beta 3
ANKRD26 ankyrin repeat domain 26
BBIP1 BBSome interacting protein 1
BBS2 Bardet-Biedl syndrome 2
BBS4 Bardet-Biedl syndrome 4
BDNF brain-derived neurotrophic factor
BRS3 bombesin-like receptor 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C3 complement component 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP19 centrosomal protein 19kDa
CLPS colipase, pancreatic
CPE carboxypeptidase E
CRTC1 CREB regulated transcription coactivator 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FTO fat mass and obesity associated
GUCY2C guanylate cyclase 2C
HNF1A HNF1 homeobox A
HRH3 histamine receptor H3
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL18 interleukin 18
INS insulin
IRS2 insulin receptor substrate 2
LCLAT1 lysocardiolipin acyltransferase 1
LEP leptin
LEPR leptin receptor
MARK4 MAP/microtubule affinity-regulating kinase 4
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MRAP2 melanocortin 2 receptor accessory protein 2
NHLH2 nescient helix loop helix 2
NMU neuromedin U
NPBWR1 neuropeptides B/W receptor 1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NTSR1 neurotensin receptor 1 (high affinity)
PANK1 pantothenate kinase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
POMC proopiomelanocortin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PYY peptide YY
RAI1 retinoic acid induced 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDC3 syndecan 3
SIM1 single-minded family bHLH transcription factor 1
SIRT1 sirtuin 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TLR5 toll-like receptor 5
TMEM27 transmembrane protein 27