positive regulation of MAPK cascade Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. (Gene Ontology, GO_0043410)
External Link http://amigo.geneontology.org/amigo/term/GO:0043410
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Genes

363 genes participating in the positive regulation of MAPK cascade biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACKR3 atypical chemokine receptor 3
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
ALKAL1 ALK and LTK ligand 1
ALKAL2 ALK and LTK ligand 2
ALOX12B arachidonate 12-lipoxygenase, 12R type
ALOX15 arachidonate 15-lipoxygenase
ANGPT1 angiopoietin 1
ANKRD6 ankyrin repeat domain 6
APELA apelin receptor early endogenous ligand
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARHGAP8 Rho GTPase activating protein 8
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
AVPI1 arginine vasopressin-induced 1
AVPR1B arginine vasopressin receptor 1B
AXIN1 axin 1
BCAR3 breast cancer anti-estrogen resistance 3
BIRC7 baculoviral IAP repeat containing 7
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPER BMP binding endothelial regulator
BRAF B-Raf proto-oncogene, serine/threonine kinase
C5AR1 complement component 5a receptor 1
CALCR calcitonin receptor
CARD9 caspase recruitment domain family, member 9
CARTPT CART prepropeptide
CAV2 caveolin 2
CCDC88C coiled-coil domain containing 88C
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CCL3 chemokine (C-C motif) ligand 3
CCM2 cerebral cavernous malformation 2
CCN2 cellular communication network factor 2
CCR1 chemokine (C-C motif) receptor 1
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD27 CD27 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CIB1 calcium and integrin binding 1 (calmyrin)
CLEC7A C-type lectin domain family 7, member A
CRACR2A calcium release activated channel regulator 2A
CRIPTO3 cripto, EGF-CFC family member 3
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF1R colony stimulating factor 1 receptor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL17 chemokine (C-X-C motif) ligand 17
DAB2IP DAB2 interacting protein
DDTL D-dopachrome tautomerase-like
DENND2B DENN domain containing 2B
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DIRAS1 DIRAS family, GTP-binding RAS-like 1
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRD1 dopamine receptor D1
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DSC3 desmocollin 3
DSTYK dual serine/threonine and tyrosine protein kinase
DUSP15 dual specificity phosphatase 15
DUSP19 dual specificity phosphatase 19
DUSP22 dual specificity phosphatase 22
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EDA2R ectodysplasin A2 receptor
EDAR ectodysplasin A receptor
EDN1 endothelin 1
EDN3 endothelin 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELANE elastase, neutrophil expressed
EPGN epithelial mitogen
EPHA8 EPH receptor A8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERP29 endoplasmic reticulum protein 29
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCRL3 Fc receptor-like 3
FERMT2 fermitin family member 2
FFAR4 free fatty acid receptor 4
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF13 fibroblast growth factor 13
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FPR2 formyl peptide receptor 2
FSHR follicle stimulating hormone receptor
FZD10 frizzled class receptor 10
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GAREM1 GRB2 associated regulator of MAPK1 subtype 1
GAS6 growth arrest-specific 6
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDF15 growth differentiation factor 15
GDF6 growth differentiation factor 6
GFRAL GDNF family receptor alpha like
GH1 growth hormone 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GLIPR2 GLI pathogenesis-related 2
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GPR101 G protein-coupled receptor 101
GPR183 G protein-coupled receptor 183
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR37L1 G protein-coupled receptor 37 like 1
GPR55 G protein-coupled receptor 55
GRM4 glutamate receptor, metabotropic 4
GSDME gasdermin E
HAND2 heart and neural crest derivatives expressed 2
HIPK2 homeodomain interacting protein kinase 2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP6 insulin-like growth factor binding protein 6
IL11 interleukin 11
IL1B interleukin 1, beta
IL26 interleukin 26
IL34 interleukin 34
IL6 interleukin 6
IL6R interleukin 6 receptor
INAVA innate immunity activator
INS insulin
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
JCAD junctional cadherin 5 associated
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHDC10 kelch domain containing 10
KSR1 kinase suppressor of ras 1
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAPTM5 lysosomal protein transmembrane 5
LEP leptin
LGALS9 lectin, galactoside-binding, soluble, 9
LIF leukemia inhibitory factor
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LPAR1 lysophosphatidic acid receptor 1
LRRK2 leucine-rich repeat kinase 2
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MADD MAP-kinase activating death domain
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK3 mitogen-activated protein kinase 3
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARCO macrophage receptor with collagenous structure
MBIP MAP3K12 binding inhibitory protein 1
MEF2C myocyte enhancer factor 2C
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MINK1 misshapen-like kinase 1
MOCOS molybdenum cofactor sulfurase
MPG N-methylpurine-DNA glycosylase
MST1R macrophage stimulating 1 receptor
MT3 metallothionein 3
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus)
MYDGF myeloid-derived growth factor
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NAIP NLR family, apoptosis inhibitory protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG4 NDRG family member 4
NECAB2 N-terminal EF-hand calcium binding protein 2
NEK10 NIMA-related kinase 10
NOD2 nucleotide-binding oligomerization domain containing 2
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOTCH2 notch 2
NPNT nephronectin
NRG1 neuregulin 1
NRK Nik related kinase
NRP1 neuropilin 1
NRXN1 neurexin 1
NTF3 neurotrophin 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OPRM1 opioid receptor, mu 1
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDCD10 programmed cell death 10
PDE8A phosphodiesterase 8A
PDE8B phosphodiesterase 8B
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHB1 prohibitin 1
PHB2 prohibitin 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G5 phospholipase A2, group V
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PRKD2 protein kinase D2
PRMT1 protein arginine methyltransferase 1
PRXL2C peroxiredoxin like 2C
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
PYCARD PYD and CARD domain containing
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RAP1A RAP1A, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELL1 RELT-like 1
RELL2 RELT-like 2
RET ret proto-oncogene
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIT2 Ras-like without CAAX 2
RNASE3 ribonuclease, RNase A family, 3
RNF13 ring finger protein 13
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RYK receptor-like tyrosine kinase
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SASH1 SAM and SH3 domain containing 1
SCIMP SLP adaptor and CSK interacting membrane protein
SDCBP syndecan binding protein (syntenin)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SH3RF1 SH3 domain containing ring finger 1
SH3RF2 SH3 domain containing ring finger 2
SH3RF3 SH3 domain containing ring finger 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC30A10 solute carrier family 30, member 10
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOD1 superoxide dismutase 1, soluble
SOS1 son of sevenless homolog 1 (Drosophila)
SOX2 SRY (sex determining region Y)-box 2
SPHK1 sphingosine kinase 1
SPI1 Spi-1 proto-oncogene
SPNS1 spinster homolog 1 (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STK25 serine/threonine kinase 25
STK39 serine threonine kinase 39
TAOK1 TAO kinase 1
TAOK2 TAO kinase 2
TAOK3 TAO kinase 3
TBX1 T-box 1
TEK TEK tyrosine kinase, endothelial
TENM1 teneurin transmembrane protein 1
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
THPO thrombopoietin
TIPE3 TNF alpha induced protein 8 like 3
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TMEM106A transmembrane protein 106A
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIK TRAF2 and NCK interacting kinase
TPD52L1 tumor protein D52-like 1
TRAF4 TNF receptor-associated factor 4
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TRIM5 tripartite motif containing 5
UNC5CL unc-5 homolog C (C. elegans)-like
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
WNT16 wingless-type MMTV integration site family, member 16
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WWC1 WW and C2 domain containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZC3H12A zinc finger CCCH-type containing 12A
ZNF622 zinc finger protein 622