positive regulation of apoptotic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. (Gene Ontology, GO_0043065)
External Link http://amigo.geneontology.org/amigo/term/GO:0043065
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Genes

314 genes participating in the positive regulation of apoptotic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACIN1 apoptotic chromatin condensation inducer 1
ACVR1C activin A receptor, type IC
ADAMTSL4 ADAMTS-like 4
ADIPOQ adiponectin, C1Q and collagen domain containing
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANO6 anoctamin 6
APAF1 apoptotic peptidase activating factor 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APP amyloid beta (A4) precursor protein
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATG7 autophagy related 7
ATM ATM serine/threonine kinase
BACE1 beta-site APP-cleaving enzyme 1
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BARD1 BRCA1 associated RING domain 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BCL6 B-cell CLL/lymphoma 6
BCLAF1 BCL2-associated transcription factor 1
BID BH3 interacting domain death agonist
BIN1 bridging integrator 1
BLID BH3-like motif containing, cell death inducer
BMF Bcl2 modifying factor
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BOK BCL2-related ovarian killer
BRMS1L breast cancer metastasis-suppressor 1-like
BTG1 B-cell translocation gene 1, anti-proliferative
C1QBP complement component 1, q subcomponent binding protein
C3ORF38 chromosome 3 open reading frame 38
CALHM2 calcium homeostasis modulator 2
CARM1 coactivator-associated arginine methyltransferase 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCAR1 cell division cycle and apoptosis regulator 1
CCAR2 cell cycle and apoptosis regulator 2
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CD160 CD160 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CIDEB cell death-inducing DFFA-like effector b
CLIP3 CAP-GLY domain containing linker protein 3
CLU clusterin
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CSRNP3 cysteine-serine-rich nuclear protein 3
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBL1 catenin, beta like 1
CTSD cathepsin D
CTSH cathepsin H
CXCR3 chemokine (C-X-C motif) receptor 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2IP DAB2 interacting protein
DAND5 DAN domain family member 5, BMP antagonist
DAPK1 death-associated protein kinase 1
DAPK2 death-associated protein kinase 2
DAPK3 death-associated protein kinase 3
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3
DDIT3 DNA-damage-inducible transcript 3
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DIABLO diablo, IAP-binding mitochondrial protein
DKKL1 dickkopf-like 1
DLC1 DLC1 Rho GTPase activating protein
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNM2 dynamin 2
DUSP6 dual specificity phosphatase 6
E2F1 E2F transcription factor 1
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator
ECT2 epithelial cell transforming 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EMILIN1 elastin microfibril interfacer 1
EMILIN2 elastin microfibril interfacer 2
EPHA7 EPH receptor A7
ERCC3 excision repair cross-complementation group 3
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FAM162A family with sequence similarity 162, member A
FANK1 fibronectin type III and ankyrin repeat domains 1
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FLCN folliculin
FOXA1 forkhead box A1
FOXL2 forkhead box L2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRZB frizzled-related protein
FZD9 frizzled class receptor 9
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GLMN glomulin, FKBP associated protein
GPER1 G protein-coupled estrogen receptor 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GRAMD4 GRAM domain containing 4
GRN granulin
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HOXA5 homeobox A5
HRK harakiri, BCL2 interacting protein
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
HTRA4 HtrA serine peptidase 4
IAPP islet amyloid polypeptide
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNB1 interferon, beta 1, fibroblast
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
ING4 inhibitor of growth family, member 4
ING5 inhibitor of growth family, member 5
IP6K2 inositol hexakisphosphate kinase 2
IRF5 interferon regulatory factor 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JMY junction mediating and regulatory protein, p53 cofactor
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF11 Kruppel-like factor 11
KNG1 kininogen 1
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LOC102724428 serine/threonine-protein kinase SIK1
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MNDA myeloid cell nuclear differentiation antigen
MOAP1 modulator of apoptosis 1
MTCH1 mitochondrial carrier 1
MTCH2 mitochondrial carrier 2
MYBBP1A MYB binding protein (P160) 1a
NANOS1 nanos homolog 1 (Drosophila)
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NEURL1 neuralized E3 ubiquitin protein ligase 1
NEUROD1 neuronal differentiation 1
NF1 neurofibromin 1
NGFR nerve growth factor receptor
NLRC4 NLR family, CARD domain containing 4
NLRP2B NLR family pyrin domain containing 2B
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
OMA1 OMA1 zinc metallopeptidase
PANO1 proapoptotic nucleolar protein 1
PAWR PRKC, apoptosis, WT1, regulator
PCSK9 proprotein convertase subtilisin/kexin type 9
PDCD2 programmed cell death 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCD5 programmed cell death 5
PDCD6 programmed cell death 6
PHB1 prohibitin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIDD1 p53-induced death domain protein 1
PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1
PLCG1 phospholipase C, gamma 1
PLEKHN1 pleckstrin homology domain containing, family N member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA1 paraneoplastic Ma antigen 1
PNMA2 paraneoplastic Ma antigen 2
PNMA3 paraneoplastic Ma antigen 3
PNMA5 paraneoplastic Ma antigen family member 5
PPARG peroxisome proliferator-activated receptor gamma
PPID peptidylprolyl isomerase D
PRDM11 PR domain containing 11
PRKCI protein kinase C, iota
PRMT2 protein arginine methyltransferase 2
PRNP prion protein
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRPF38B pre-mRNA processing factor 38B
PRR7 proline rich 7 (synaptic)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRA protein tyrosine phosphatase, receptor type, A
PTRH2 peptidyl-tRNA hydrolase 2
PYCARD PYD and CARD domain containing
QRICH1 glutamine-rich 1
RACK1 receptor for activated C kinase 1
RARG retinoic acid receptor, gamma
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM5 RNA binding motif protein 5
REST RE1-silencing transcription factor
RGCC regulator of cell cycle
RHOB ras homolog family member B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RNPS1 RNA binding protein S1, serine-rich domain
RPS3 ribosomal protein S3
RPS6 ribosomal protein S6
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRP1B ribosomal RNA processing 1B
RYBP RING1 and YY1 binding protein
SAP18 Sin3A-associated protein, 18kDa
SAV1 salvador family WW domain containing protein 1
SCIN scinderin
SCRIB scribbled planar cell polarity protein
SEPTIN4 septin 4
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP4 secreted frizzled-related protein 4
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLIT2 slit homolog 2 (Drosophila)
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPHK2 sphingosine kinase 2
SQSTM1 sequestosome 1
SRPK2 SRSF protein kinase 2
STK17A serine/threonine kinase 17a
STK17B serine/threonine kinase 17b
STK24 serine/threonine kinase 24
STK4 serine/threonine kinase 4
STPG1 sperm-tail PG-rich repeat containing 1
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TCTN3 tectonic family member 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TLE5 TLE family member 5, transcriptional modulator
TMC8 transmembrane channel-like 8
TMEM196 transmembrane protein 196
TNF tumor necrosis factor
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TPD52L1 tumor protein D52-like 1
TRADD TNFRSF1A-associated via death domain
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TRIM35 tripartite motif containing 35
TRIM39 tripartite motif containing 39
TSC22D1 TSC22 domain family, member 1
UBD ubiquitin D
UBE2Z ubiquitin-conjugating enzyme E2Z
UNC13B unc-13 homolog B (C. elegans)
USP17L24 ubiquitin specific peptidase 17-like family member 24
USP27X ubiquitin specific peptidase 27, X-linked
UTP11 UTP11 small subunit processome component
VDAC1 voltage-dependent anion channel 1
WNT10B wingless-type MMTV integration site family, member 10B
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
ZBP1 Z-DNA binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF268 zinc finger protein 268
ZNF622 zinc finger protein 622