positive regulation of defense response Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that activates or increases the frequency, rate or extent of a defense response. (Gene Ontology, GO_0031349)
External Link http://amigo.geneontology.org/amigo/term/GO:0031349
Similar Terms
Downloads & Tools

Genes

131 genes participating in the positive regulation of defense response biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACOD1 aconitate decarboxylase 1
ADAM8 ADAM metallopeptidase domain 8
AGTR1 angiotensin II receptor, type 1
AGXT alanine-glyoxylate aminotransferase
AIM2 absent in melanoma 2
AKIRIN2 akirin 2
APP amyloid beta (A4) precursor protein
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCL1 chemokine (C-C motif) ligand 1
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCM2 cerebral cavernous malformation 2
CCN4 cellular communication network factor 4
CCR2 chemokine (C-C motif) receptor 2
CD1D CD1d molecule
CD47 CD47 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPT1A carnitine palmitoyltransferase 1A (liver)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYBA cytochrome b-245, alpha polypeptide
DDTL D-dopachrome tautomerase-like
DEFB114 defensin, beta 114
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
EMILIN1 elastin microfibril interfacer 1
EMILIN2 elastin microfibril interfacer 2
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADD Fas (TNFRSF6)-associated via death domain
FEM1C fem-1 homolog c (C. elegans)
FPR2 formyl peptide receptor 2
GBP5 guanylate binding protein 5
GPR4 G protein-coupled receptor 4
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPSM3 G-protein signaling modulator 3
GRN granulin
GRPR gastrin-releasing peptide receptor
GSDMD gasdermin D
HYAL2 hyaluronoglucosaminidase 2
IFI35 interferon-induced protein 35
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNK interferon, kappa
IL12B interleukin 12B
IL15 interleukin 15
IL16 interleukin 16
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL21 interleukin 21
IL23A interleukin 23, alpha subunit p19
IL33 interleukin 33
IRGM immunity-related GTPase family, M
KAT5 K(lysine) acetyltransferase 5
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LPL lipoprotein lipase
LRSAM1 leucine rich repeat and sterile alpha motif containing 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK13 mitogen-activated protein kinase 13
MDK midkine (neurite growth-promoting factor 2)
MEF2C myocyte enhancer factor 2C
MEFV Mediterranean fever
MGST2 microsomal glutathione S-transferase 2
MMRN2 multimerin 2
NAIP NLR family, apoptosis inhibitory protein
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NINJ1 ninjurin 1
NKG7 natural killer cell granule protein 7
NLRC4 NLR family, CARD domain containing 4
NLRP1 NLR family, pyrin domain containing 1
NLRP10 NLR family, pyrin domain containing 10
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NMI N-myc (and STAT) interactor
NPAS2 neuronal PAS domain protein 2
OPTN optineurin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLSCR1 phospholipid scramblase 1
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PYCARD PYD and CARD domain containing
RIOK3 RIO kinase 3
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF185 ring finger protein 185
RNF31 ring finger protein 31
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETD4 SET domain containing 4
SH2D1B SH2 domain containing 1B
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene)
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
TASL TLR adaptor interacting with endolysosomal SLC15A4
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TRADD TNFRSF1A-associated via death domain
TRIM56 tripartite motif containing 56
TSLP thymic stromal lymphopoietin
UCMA upper zone of growth plate and cartilage matrix associated
WNT5A wingless-type MMTV integration site family, member 5A
ZBP1 Z-DNA binding protein 1
ZDHHC4 zinc finger, DHHC-type containing 4
ZP3 zona pellucida glycoprotein 3 (sperm receptor)