positive regulation of protein catabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. (Gene Ontology, GO_0045732)
External Link http://amigo.geneontology.org/amigo/term/GO:0045732
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Genes

100 genes participating in the positive regulation of protein catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADRA2A adrenoceptor alpha 2A
AMER1 APC membrane recruitment protein 1
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
ASB5 ankyrin repeat and SOCS box containing 5
ASB9 ankyrin repeat and SOCS box containing 9
ATG7 autophagy related 7
AXIN1 axin 1
BAG2 BCL2-associated athanogene 2
BARD1 BRCA1 associated RING domain 1
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
CD81 CD81 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8
CREBRF CREB3 regulatory factor
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2A3 casein kinase 2, alpha 3 polypeptide
CUL4A cullin 4A
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAOA D-amino acid oxidase activator
DCAF1 DDB1 and CUL4 associated factor 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDRGK1 DDRGK domain containing 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator
EGLN2 egl-9 family hypoxia-inducible factor 2
EZR ezrin
FAF1 Fas (TNFRSF6) associated factor 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FMR1 fragile X mental retardation 1
FOXO1 forkhead box O1
FURIN furin (paired basic amino acid cleaving enzyme)
GPC3 glypican 3
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IDE insulin-degrading enzyme
IFNG interferon, gamma
IL1B interleukin 1, beta
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
MSN moesin
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEURL3 neuralized E3 ubiquitin protein ligase 3
NKD1 naked cuticle homolog 1 (Drosophila)
NRDC nardilysin convertase
NSF N-ethylmaleimide-sensitive factor
NUPR1 nuclear protein, transcriptional regulator, 1
OAZ1 ornithine decarboxylase antizyme 1
OAZ2 ornithine decarboxylase antizyme 2
OAZ3 ornithine decarboxylase antizyme 3
OSBPL7 oxysterol binding protein-like 7
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCSK9 proprotein convertase subtilisin/kexin type 9
PLK2 polo-like kinase 2
PLK3 polo-like kinase 3
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRICKLE1 prickle homolog 1 (Drosophila)
PRKN parkin RBR E3 ubiquitin protein ligase
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
RAB7A RAB7A, member RAS oncogene family
RBX1 ring-box 1, E3 ubiquitin protein ligase
RDX radixin
RHBDD1 rhomboid domain containing 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SH3D19 SH3 domain containing 19
SNF8 SNF8, ESCRT-II complex subunit
SNX33 sorting nexin 33
SNX9 sorting nexin 9
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STX5 syntaxin 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMTC3 transmembrane and tetratricopeptide repeat containing 3
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TREM2 triggering receptor expressed on myeloid cells 2
TRIM32 tripartite motif containing 32
UBXN2A UBX domain protein 2A
VCP valosin containing protein
VGLL4 vestigial-like family member 4
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
WNT5A wingless-type MMTV integration site family, member 5A
ZNF268 zinc finger protein 268