positive regulation of proteolysis Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. (Gene Ontology, GO_0045862)
External Link http://amigo.geneontology.org/amigo/term/GO:0045862
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Genes

53 genes participating in the positive regulation of proteolysis biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADRA2A adrenoceptor alpha 2A
ANGPTL8 angiopoietin like 8
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ASPH aspartate beta-hydroxylase
ASTL astacin-like metallo-endopeptidase (M12 family)
ATP5IF1 ATP synthase inhibitory factor subunit 1
AURKAIP1 aurora kinase A interacting protein 1
BAD BCL2-associated agonist of cell death
BAG2 BCL2-associated athanogene 2
BAK1 BCL2-antagonist/killer 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAPN3 calpain 3, (p94)
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCBE1 collagen and calcium binding EGF domains 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CTSC cathepsin C
CTSH cathepsin H
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDRGK1 DDRGK domain containing 1
FADD Fas (TNFRSF6)-associated via death domain
FBXW11 F-box and WD repeat domain containing 11
FGFR4 fibroblast growth factor receptor 4
FURIN furin (paired basic amino acid cleaving enzyme)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HDAC2 histone deacetylase 2
IFNG interferon, gamma
IL1B interleukin 1, beta
IST1 increased sodium tolerance 1 homolog (yeast)
MAPK12 mitogen-activated protein kinase 12
NKD2 naked cuticle homolog 2 (Drosophila)
NLRC4 NLR family, CARD domain containing 4
NRDC nardilysin convertase
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PERP PERP, TP53 apoptosis effector
PLK1 polo-like kinase 1
PRSS22 protease, serine, 22
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RHBDD1 rhomboid domain containing 1
SH3D19 SH3 domain containing 19
SNX33 sorting nexin 33
SNX9 sorting nexin 9
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBC1D10A TBC1 domain family, member 10A
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNP1 transition protein 1 (during histone to protamine replacement)
TNP2 transition protein 2 (during histone to protamine replacement)
TRIM32 tripartite motif containing 32
UFL1 UFM1-specific ligase 1