positive regulation of signal transduction Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that activates or increases the frequency, rate or extent of signal transduction. (Gene Ontology, GO_0009967)
External Link http://amigo.geneontology.org/amigo/term/GO:0009967
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Genes

257 genes participating in the positive regulation of signal transduction biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ACVR1 activin A receptor, type I
ACVRL1 activin A receptor type II-like 1
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADGRG1 adhesion G protein-coupled receptor G1
ADIPOQ adiponectin, C1Q and collagen domain containing
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
APP amyloid beta (A4) precursor protein
ARMC9 armadillo repeat containing 9
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
AXL AXL receptor tyrosine kinase
BDNF brain-derived neurotrophic factor
BMP2 bone morphogenetic protein 2
BMP2K BMP2 inducible kinase
BMP6 bone morphogenetic protein 6
C1QTNF12 C1q and TNF related 12
C3 complement component 3
CCBE1 collagen and calcium binding EGF domains 1
CCDC134 coiled-coil domain containing 134
CCL5 chemokine (C-C motif) ligand 5
CCN3 cellular communication network factor 3
CD180 CD180 molecule
CD226 CD226 molecule
CD63 CD63 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CDC73 cell division cycle 73
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN2AIP CDKN2A interacting protein
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CIBAR1 CBY1 interacting BAR domain containing 1
CLEC6A C-type lectin domain family 6, member A
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRBN cereblon
CRLF2 cytokine receptor-like factor 2
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSH cathepsin H
CUX2 cut-like homeobox 2
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAND5 DAN domain family member 5, BMP antagonist
DCDC2 doublecortin domain containing 2
DEPDC1B DEP domain containing 1B
DHH desert hedgehog
DISC1 disrupted in schizophrenia 1
DLG5 discs, large homolog 5 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DLL4 delta-like 4 (Drosophila)
DSTYK dual serine/threonine and tyrosine protein kinase
EFNA1 ephrin-A1
EMP2 epithelial membrane protein 2
ENHO energy homeostasis associated
EPHA4 EPH receptor A4
EPHB2 EPH receptor B2
EPN2 epsin 2
ERFE erythroferrone
ESM1 endothelial cell-specific molecule 1
EVC Ellis van Creveld protein
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FASN fatty acid synthase
FGF1 fibroblast growth factor 1 (acidic)
FGFBP3 fibroblast growth factor binding protein 3
FGFR2 fibroblast growth factor receptor 2
FLNA filamin A, alpha
GAS6 growth arrest-specific 6
GAS8 growth arrest-specific 8
GATA3 GATA binding protein 3
GATA5 GATA binding protein 5
GDF2 growth differentiation factor 2
GH1 growth hormone 1
GHRH growth hormone releasing hormone
GHRHR growth hormone releasing hormone receptor
GHRL ghrelin/obestatin prepropeptide
GKAP1 G kinase anchoring protein 1
GLI1 GLI family zinc finger 1
GPER1 G protein-coupled estrogen receptor 1
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRB10 growth factor receptor-bound protein 10
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
HAND2 heart and neural crest derivatives expressed 2
HAP1 huntingtin-associated protein 1
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOMER1 homer scaffolding protein 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IHH indian hedgehog
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
ILK integrin-linked kinase
ING5 inhibitor of growth family, member 5
INS insulin
IRS1 insulin receptor substrate 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB1BP1 integrin beta 1 binding protein 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG1 jagged 1
JAG2 jagged 2
JAK2 Janus kinase 2
JCAD junctional cadherin 5 associated
KANK1 KN motif and ankyrin repeat domains 1
KIF7 kinesin family member 7
KLK14 kallikrein-related peptidase 14
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LGR6 leucine-rich repeat containing G protein-coupled receptor 6
LIF leukemia inhibitory factor
LIMS1 LIM and senescent cell antigen-like domains 1
LIMS2 LIM and senescent cell antigen-like domains 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMNB2 lamin B2
LOXL3 lysyl oxidase-like 3
LY86 lymphocyte antigen 86
LY96 lymphocyte antigen 96
MACF1 microtubule-actin crosslinking factor 1
MBD5 methyl-CpG binding domain protein 5
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIA3 melanoma inhibitory activity family, member 3
MT3 metallothionein 3
MYORG myogenesis regulating glycosidase (putative)
NANOS3 nanos homolog 3 (Drosophila)
NECAB2 N-terminal EF-hand calcium binding protein 2
NEPRO nucleolus and neural progenitor protein
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NID1 nidogen 1
NLGN1 neuroligin 1
NLGN2 neuroligin 2
NLGN3 neuroligin 3
NLK nemo-like kinase
NOD2 nucleotide-binding oligomerization domain containing 2
NOTCH2NLB notch 2 N-terminal like B
NOTCH2NLC notch 2 N-terminal like C
NPTN neuroplastin
NRXN1 neurexin 1
PCDH11Y protocadherin 11 Y-linked
PDCD10 programmed cell death 10
PDCL phosducin-like
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PECAM1 platelet/endothelial cell adhesion molecule 1
PHB1 prohibitin 1
PHIP pleckstrin homology domain interacting protein
PIH1D1 PIH1 domain containing 1
PLPP3 phospholipid phosphatase 3
POGLUT1 protein O-glucosyltransferase 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRKD2 protein kinase D2
PRNP prion protein
PTEN phosphatase and tensin homolog
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
RAB34 RAB34, member RAS oncogene family
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RELN reelin
RIMS1 regulating synaptic membrane exocytosis 1
RIMS2 regulating synaptic membrane exocytosis 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
RPS3 ribosomal protein S3
RSPO1 R-spondin 1
RSPO2 R-spondin 2
RSPO3 R-spondin 3
RSPO4 R-spondin 4
SALL1 spalt-like transcription factor 1
SASH1 SAM and SH3 domain containing 1
SCIMP SLP adaptor and CSK interacting membrane protein
SFRP1 secreted frizzled-related protein 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHH sonic hedgehog
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMOC2 SPARC related modular calcium binding 2
SNX5 sorting nexin 5
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPNS1 spinster homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK36 serine/threonine kinase 36
STX1B syntaxin 1B
SULF1 sulfatase 1
SULF2 sulfatase 2
TEDC1 tubulin epsilon and delta complex 1
TEDC2 tubulin epsilon and delta complex 2
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TLR2 toll-like receptor 2
TM2D3 TM2 domain containing 3
TMEM108 transmembrane protein 108
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNXB tenascin XB
TP63 tumor protein p63
TPD52L1 tumor protein D52-like 1
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
TREM2 triggering receptor expressed on myeloid cells 2
TRIM39 tripartite motif containing 39
TRIM44 tripartite motif containing 44
TSLP thymic stromal lymphopoietin
TSPAN14 tetraspanin 14
TSPAN5 tetraspanin 5
TTC23 tetratricopeptide repeat domain 23
TUBD1 tubulin, delta 1
TXNDC15 thioredoxin domain containing 15
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
ULK3 unc-51 like kinase 3
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VTN vitronectin
VWF von Willebrand factor
WLS wntless Wnt ligand secretion mediator
WNT1 wingless-type MMTV integration site family, member 1
WNT5A wingless-type MMTV integration site family, member 5A
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZDHHC5 zinc finger, DHHC-type containing 5
ZMIZ1 zinc finger, MIZ-type containing 1
ZRANB1 zinc finger, RAN-binding domain containing 1