postsynaptic density Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases. The postsynaptic density may be part of a neuron or a muscle cell or a glial cell. (Gene Ontology, GO_0014069)
External Link http://amigo.geneontology.org/amigo/term/GO:0014069
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165 proteins localized to the postsynaptic density cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ABI3 ABI family, member 3
ADAM22 ADAM metallopeptidase domain 22
ADCY8 adenylate cyclase 8 (brain)
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADD3 adducin 3 (gamma)
ADGRA1 adhesion G protein-coupled receptor A1
ADGRB1 adhesion G protein-coupled receptor B1
AKAP5 A kinase (PRKA) anchor protein 5
ARHGAP32 Rho GTPase activating protein 32
ARHGAP44 Rho GTPase activating protein 44
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ASIC1 acid sensing (proton gated) ion channel 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
CABP1 calcium binding protein 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CACNG3 calcium channel, voltage-dependent, gamma subunit 3
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CACNG5 calcium channel, voltage-dependent, gamma subunit 5
CACNG7 calcium channel, voltage-dependent, gamma subunit 7
CACNG8 calcium channel, voltage-dependent, gamma subunit 8
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CNIH2 cornichon family AMPA receptor auxiliary protein 2
CORIN corin, serine peptidase
CPEB4 cytoplasmic polyadenylation element binding protein 4
CRIPT cysteine-rich PDZ-binding protein
CTNND2 catenin (cadherin-associated protein), delta 2
DAGLA diacylglycerol lipase, alpha
DISC1 disrupted in schizophrenia 1
DLG1 discs, large homolog 1 (Drosophila)
DLG5 discs, large homolog 5 (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNM2 dynamin 2
DNM3 dynamin 3
DTNB dystrobrevin, beta
DTNBP1 dystrobrevin binding protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM81A family with sequence similarity 81, member A
FMR1 fragile X mental retardation 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAP43 growth associated protein 43
GPER1 G protein-coupled estrogen receptor 1
GPHN gephyrin
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRID1 glutamate receptor, ionotropic, delta 1
GRID2 glutamate receptor, ionotropic, delta 2
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK3 glutamate receptor, ionotropic, kainate 3
GRIK4 glutamate receptor, ionotropic, kainate 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM1 glutamate receptor, metabotropic 1
GRM5 glutamate receptor, metabotropic 5
GSG1L GSG1-like
HIP1R huntingtin interacting protein 1 related
HOMER1 homer scaffolding protein 1
HOMER2 homer scaffolding protein 2
HOMER3 homer scaffolding protein 3
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSYN1 inhibitory synaptic factor 1
INSYN2A inhibitory synaptic factor 2A
IQSEC3 IQ motif and Sec7 domain 3
KALRN kalirin, RhoGEF kinase
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRFN1 leucine rich repeat and fibronectin type III domain containing 1
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRFN5 leucine rich repeat and fibronectin type III domain containing 5
LRRC4 leucine rich repeat containing 4
LRRC4B leucine rich repeat containing 4B
LRRC4C leucine rich repeat containing 4C
LRRC7 leucine rich repeat containing 7
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTMR2 myotubularin related protein 2
NANOS1 nanos homolog 1 (Drosophila)
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NEURL1 neuralized E3 ubiquitin protein ligase 1
NLGN1 neuroligin 1
NLGN4X neuroligin 4, X-linked
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PDLIM5 PDZ and LIM domain 5
PICK1 protein interacting with PRKCA 1
PLPPR4 phospholipid phosphatase related 4
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PTK2B protein tyrosine kinase 2 beta
PTPRS protein tyrosine phosphatase, receptor type, S
RGS14 regulator of G-protein signaling 14
RHEB Ras homolog enriched in brain
RNF112 ring finger protein 112
RPL12 ribosomal protein L12
RPL14 ribosomal protein L14
RPL30 ribosomal protein L30
RPL38 ribosomal protein L38
RPL7 ribosomal protein L7
RPL8 ribosomal protein L8
RPLP0 ribosomal protein, large, P0
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS18 ribosomal protein S18
RPS19 ribosomal protein S19
RPS25 ribosomal protein S25
RPS27 ribosomal protein S27
RPS3 ribosomal protein S3
RTN1 reticulon 1
RTN2 reticulon 2
RTN3 reticulon 3
RTN4 reticulon 4
SAMD14 sterile alpha motif domain containing 14
SCRIB scribbled planar cell polarity protein
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SH2D5 SH2 domain containing 5
SHANK1 SH3 and multiple ankyrin repeat domains 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHISA6 shisa family member 6
SHISA7 shisa family member 7
SHISA8 shisa family member 8
SHISA9 shisa family member 9
SIGMAR1 sigma non-opioid intracellular receptor 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLITRK1 SLIT and NTRK-like family, member 1
SLITRK3 SLIT and NTRK-like family, member 3
SORCS3 sortilin-related VPS10 domain containing receptor 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRCIN1 SRC kinase signaling inhibitor 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STRN striatin, calmodulin binding protein
SYNDIG1 synapse differentiation inducing 1
SYT12 synaptotagmin XII
TMEM108 transmembrane protein 108
TSC2 tuberous sclerosis 2
USP50 ubiquitin specific peptidase 50
USP6 ubiquitin specific peptidase 6
USP8 ubiquitin specific peptidase 8
ZDHHC2 zinc finger, DHHC-type containing 2