pou5f1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description POU class 5 homeobox 1|This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013] (NCBI Entrez Gene Database, 5460)
Similar Terms
Downloads & Tools

Genes

22 genes co-occuring with the biological term pou5f1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
CGA glycoprotein hormones, alpha polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FZD5 frizzled class receptor 5
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GDF11 growth differentiation factor 11
IGF1R insulin-like growth factor 1 receptor
MMP2 matrix metallopeptidase 2
MSTN myostatin
NANOG Nanog homeobox
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
POU5F1B POU class 5 homeobox 1B
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SOX2 SRY (sex determining region Y)-box 2
TCF19 transcription factor 19
WNT8B wingless-type MMTV integration site family, member 8B
WWP2 WW domain containing E3 ubiquitin protein ligase 2