pparg Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description peroxisome proliferator-activated receptor gamma|This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5468)
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Genes

53 genes co-occuring with the biological term pparg in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ATF3 activating transcription factor 3
CAV1 caveolin 1, caveolae protein, 22kDa
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CUL1 cullin 1
EGFR epidermal growth factor receptor
ESR2 estrogen receptor 2 (ER beta)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FXN frataxin
HHEX hematopoietically expressed homeobox
HNF4A hepatocyte nuclear factor 4, alpha
IDE insulin-degrading enzyme
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRS1 insulin receptor substrate 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KIF11 kinesin family member 11
KL klotho
LGALS9 lectin, galactoside-binding, soluble, 9
LPA lipoprotein, Lp(a)
LPIN1 lipin 1
LPL lipoprotein lipase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NSD1 nuclear receptor binding SET domain protein 1
PAX8 paired box 8
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RARG retinoic acid receptor, gamma
RXRA retinoid X receptor, alpha
SIRT1 sirtuin 1
SKP1 S-phase kinase-associated protein 1
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SPI1 Spi-1 proto-oncogene
STAT5B signal transducer and activator of transcription 5B
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UBR1 ubiquitin protein ligase E3 component n-recognin 1
VCAM1 vascular cell adhesion molecule 1