ppargc1a Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha\|The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10891)
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Genes

17 genes co-occuring with the biological term ppargc1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
ACE	angiotensin I converting enzyme
ACTN3	actinin, alpha 3 (gene/pseudogene)
AR	androgen receptor
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1
EP300	E1A binding protein p300
FLCN	folliculin
FNDC5	fibronectin type III domain containing 5
HNF4A	hepatocyte nuclear factor 4, alpha
NOS2	nitric oxide synthase 2, inducible
NRF1	nuclear respiratory factor 1
PPARA	peroxisome proliferator-activated receptor alpha
PPARD	peroxisome proliferator-activated receptor delta
PPARG	peroxisome proliferator-activated receptor gamma
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)
TP53	tumor protein p53