practolol-1587 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the practolol-1587 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADM2 adrenomedullin 2
AHR aryl hydrocarbon receptor
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOC4 apolipoprotein C-IV
ARG1 arginase 1
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP9B ATPase, class II, type 9B
ATR ATR serine/threonine kinase
AXL AXL receptor tyrosine kinase
BPI bactericidal/permeability-increasing protein
C19ORF66 chromosome 19 open reading frame 66
C6ORF106 chromosome 6 open reading frame 106
CALML4 calmodulin-like 4
CANT1 calcium activated nucleotidase 1
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD86 CD86 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEL carboxyl ester lipase
CKB creatine kinase, brain
CLCN7 chloride channel, voltage-sensitive 7
CS citrate synthase
DGCR14 DiGeorge syndrome critical region gene 14
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DSCR3 Down syndrome critical region 3
ECT2 epithelial cell transforming 2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
FAM134A family with sequence similarity 134, member A
FAM188A family with sequence similarity 188, member A
FSCN3 fascin actin-bundling protein 3, testicular
GCFC2 GC-rich sequence DNA-binding factor 2
GSK3A glycogen synthase kinase 3 alpha
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HPCAL1 hippocalcin-like 1
IFI6 interferon, alpha-inducible protein 6
INO80D INO80 complex subunit D
IRF4 interferon regulatory factor 4
JUN jun proto-oncogene
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIAA1467 KIAA1467
LACTB2 lactamase, beta 2
LPP LIM domain containing preferred translocation partner in lipoma
LRRK1 leucine-rich repeat kinase 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MBTD1 mbt domain containing 1
MED16 mediator complex subunit 16
MEGF6 multiple EGF-like-domains 6
MOSPD2 motile sperm domain containing 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL10 myosin, light chain 10, regulatory
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTAN1 N-terminal asparagine amidase
OGFRL1 opioid growth factor receptor-like 1
PAM peptidylglycine alpha-amidating monooxygenase
PDLIM7 PDZ and LIM domain 7 (enigma)
PGLYRP4 peptidoglycan recognition protein 4
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAGL2 pleiomorphic adenoma gene-like 2
PLCD1 phospholipase C, delta 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRR4 proline rich 4 (lacrimal)
RAB33B RAB33B, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
RGS13 regulator of G-protein signaling 13
RIN1 Ras and Rab interactor 1
RSF1 remodeling and spacing factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SIGLEC7 sialic acid binding Ig-like lectin 7
SKI SKI proto-oncogene
SMIM7 small integral membrane protein 7
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX15 sorting nexin 15
SNX19 sorting nexin 19
SON SON DNA binding protein
SPP1 secreted phosphoprotein 1
SPPL2B signal peptide peptidase like 2B
TANK TRAF family member-associated NFKB activator
TM9SF4 transmembrane 9 superfamily protein member 4
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM45A transmembrane protein 45A
TRAPPC11 trafficking protein particle complex 11
TTC37 tetratricopeptide repeat domain 37
UBQLN4 ubiquilin 4
UNC119B unc-119 homolog B (C. elegans)
VASP vasodilator-stimulated phosphoprotein
VIPR2 vasoactive intestinal peptide receptor 2
YIPF4 Yip1 domain family, member 4
ZBTB7A zinc finger and BTB domain containing 7A
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ACTN4 actinin, alpha 4
ADAT1 adenosine deaminase, tRNA-specific 1
APH1A APH1A gamma secretase subunit
APOC2 apolipoprotein C-II
ARHGAP10 Rho GTPase activating protein 10
ARMCX5 armadillo repeat containing, X-linked 5
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCAP31 B-cell receptor-associated protein 31
BCL2L14 BCL2-like 14 (apoptosis facilitator)
CAPN7 calpain 7
CD248 CD248 molecule, endosialin
CDK5 cyclin-dependent kinase 5
CDK9 cyclin-dependent kinase 9
CEP85 centrosomal protein 85kDa
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COMMD10 COMM domain containing 10
CORO2A coronin, actin binding protein, 2A
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCLRE1B DNA cross-link repair 1B
DDA1 DET1 and DDB1 associated 1
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DPF3 D4, zinc and double PHD fingers, family 3
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EGLN2 egl-9 family hypoxia-inducible factor 2
ERCC2 excision repair cross-complementation group 2
FPGS folylpolyglutamate synthase
FPGT fucose-1-phosphate guanylyltransferase
FTO fat mass and obesity associated
GMCL1 germ cell-less, spermatogenesis associated 1
GPS1 G protein pathway suppressor 1
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HLTF helicase-like transcription factor
HMGB3P1 high mobility group box 3 pseudogene 1
IFITM3 interferon induced transmembrane protein 3
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INPPL1 inositol polyphosphate phosphatase-like 1
KCTD20 potassium channel tetramerization domain containing 20
KIF13B kinesin family member 13B
KRT38 keratin 38, type I
LGALS9 lectin, galactoside-binding, soluble, 9
LIAS lipoic acid synthetase
LRRC37A3 leucine rich repeat containing 37, member A3
LTB lymphotoxin beta (TNF superfamily, member 3)
MATK megakaryocyte-associated tyrosine kinase
MGLL monoglyceride lipase
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
NCAPD2 non-SMC condensin I complex, subunit D2
NUBP2 nucleotide binding protein 2
NVL nuclear VCP-like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSGEP O-sialoglycoprotein endopeptidase
PCID2 PCI domain containing 2
PCTP phosphatidylcholine transfer protein
PES1 pescadillo ribosomal biogenesis factor 1
PEX26 peroxisomal biogenesis factor 26
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RFPL3 ret finger protein-like 3
RFX7 regulatory factor X, 7
RPE ribulose-5-phosphate-3-epimerase
RPL11 ribosomal protein L11
RPL23AP32 ribosomal protein L23a pseudogene 32
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SAC3D1 SAC3 domain containing 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SOBP sine oculis binding protein homolog (Drosophila)
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRRD SRR1 domain containing
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STEAP3 STEAP family member 3, metalloreductase
SYNGR2 synaptogyrin 2
TEX264 testis expressed 264
TEX30 testis expressed 30
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM168 transmembrane protein 168
TMEM184B transmembrane protein 184B
TMEM50B transmembrane protein 50B
TTC31 tetratricopeptide repeat domain 31
TXLNA taxilin alpha
TXNL4B thioredoxin-like 4B
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBFD1 ubiquitin family domain containing 1
UGDH UDP-glucose 6-dehydrogenase
UNC13B unc-13 homolog B (C. elegans)
WDR5B WD repeat domain 5B
WWC2 WW and C2 domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF197 zinc finger protein 197
ZNF281 zinc finger protein 281
ZNF432 zinc finger protein 432