pramocaine-3894 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pramocaine-3894 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADORA1 adenosine A1 receptor
ALDOB aldolase B, fructose-bisphosphate
ALOXE3 arachidonate lipoxygenase 3
AMPH amphiphysin
APAF1 apoptotic peptidase activating factor 1
ATP9B ATPase, class II, type 9B
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C19ORF66 chromosome 19 open reading frame 66
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC7 coiled-coil domain containing 7
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD84 CD84 molecule
CELF2 CUGBP, Elav-like family member 2
CLSTN3 calsyntenin 3
CNTD2 cyclin N-terminal domain containing 2
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DICER1 dicer 1, ribonuclease type III
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DRD2 dopamine receptor D2
EFS embryonal Fyn-associated substrate
EPHA5 EPH receptor A5
EPHB2 EPH receptor B2
FBXL7 F-box and leucine-rich repeat protein 7
FBXO4 F-box protein 4
FCMR Fc fragment of IgM receptor
FFAR3 free fatty acid receptor 3
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXG1 forkhead box G1
GLI1 GLI family zinc finger 1
GSK3A glycogen synthase kinase 3 alpha
GSTP1 glutathione S-transferase pi 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BO histone cluster 1, H2bo
HOXA7 homeobox A7
HOXD11 homeobox D11
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGLJ3 immunoglobulin lambda joining 3
IL23A interleukin 23, alpha subunit p19
INO80D INO80 complex subunit D
IPCEF1 interaction protein for cytohesin exchange factors 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KEL Kell blood group, metallo-endopeptidase
LAMA2 laminin, alpha 2
LMTK1 lemur tail kinase 1
LOC440895 two pore channel 3 pseudogene
LPCAT4 lysophosphatidylcholine acyltransferase 4
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene)
MAP2K5 mitogen-activated protein kinase kinase 5
MC5R melanocortin 5 receptor
MEP1B meprin A, beta
METTL7A methyltransferase like 7A
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MRPL41 mitochondrial ribosomal protein L41
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYO7A myosin VIIA
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDOR1 NADPH dependent diflavin oxidoreductase 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OSBPL7 oxysterol binding protein-like 7
PARVA parvin, alpha
PCDHGA3 protocadherin gamma subfamily A, 3
PDE4A phosphodiesterase 4A, cAMP-specific
PLIN2 perilipin 2
PQLC3 PQ loop repeat containing 3
PRAMEF10 PRAME family member 10
PRB4 proline-rich protein BstNI subfamily 4
RAB3B RAB3B, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RBM5 RNA binding motif protein 5
RECQL5 RecQ protein-like 5
RORA RAR-related orphan receptor A
SARM1 sterile alpha and TIR motif containing 1
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4
SLC17A2 solute carrier family 17, member 2
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SOX2 SRY (sex determining region Y)-box 2
SRSF7 serine/arginine-rich splicing factor 7
TMEM259 transmembrane protein 259
TMPRSS4 transmembrane protease, serine 4
TTLL7 tubulin tyrosine ligase-like family member 7
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB17 zinc finger and BTB domain containing 17
ZNF343 zinc finger protein 343
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ALOX12 arachidonate 12-lipoxygenase
ALPK1 alpha-kinase 1
APLP1 amyloid beta (A4) precursor-like protein 1
BAGE B melanoma antigen
C10ORF95 chromosome 10 open reading frame 95
CALML5 calmodulin-like 5
CAMK1 calcium/calmodulin-dependent protein kinase I
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CNGB3 cyclic nucleotide gated channel beta 3
CRIP1 cysteine-rich protein 1 (intestinal)
CSF1R colony stimulating factor 1 receptor
CTSF cathepsin F
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
DPY19L1P1 DPY19L1 pseudogene 1
ETV6 ets variant 6
FBXO22 F-box protein 22
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGL1 fibrinogen-like 1
FKBP10 FK506 binding protein 10, 65 kDa
FLT4 fms-related tyrosine kinase 4
FMOD fibromodulin
FRMD1 FERM domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FURIN furin (paired basic amino acid cleaving enzyme)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
HIST1H1D histone cluster 1, H1d
HIST1H2BM histone cluster 1, H2bm
HIST1H4D histone cluster 1, H4d
HOXA4 homeobox A4
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSF4 heat shock transcription factor 4
IQCC IQ motif containing C
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KLHL25 kelch-like family member 25
KLK8 kallikrein-related peptidase 8
KRT15 keratin 15, type I
LINS lines homolog (Drosophila)
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP2 latent transforming growth factor beta binding protein 2
LYPLA2P1 lysophospholipase II pseudogene 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK8 mitogen-activated protein kinase 8
MATK megakaryocyte-associated tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MVD mevalonate (diphospho) decarboxylase
MYL5 myosin, light chain 5, regulatory
MYO1F myosin IF
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NME5 NME/NM23 family member 5
OSMR oncostatin M receptor
PARG poly (ADP-ribose) glycohydrolase
POM121 POM121 transmembrane nucleoporin
PP14571 uncharacterized LOC100130449
PPARG peroxisome proliferator-activated receptor gamma
RSG1 REM2 and RAB-like small GTPase 1
S100A2 S100 calcium binding protein A2
SCML2 sex comb on midleg-like 2 (Drosophila)
SIGLEC15 sialic acid binding Ig-like lectin 15
SIX1 SIX homeobox 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNTA1 syntrophin, alpha 1
SP1 Sp1 transcription factor
STAB2 stabilin 2
STARD3 StAR-related lipid transfer (START) domain containing 3
SYCP2 synaptonemal complex protein 2
TBC1D2 TBC1 domain family, member 2
TCP10 t-complex 10
TFF2 trefoil factor 2
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TNS2 tensin 2
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSC22D4 TSC22 domain family, member 4
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
UPK2 uroplakin 2
USP6NL USP6 N-terminal like
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WNT16 wingless-type MMTV integration site family, member 16
ZNF205 zinc finger protein 205
ZNF428 zinc finger protein 428
ZNF76 zinc finger protein 76