pravastatin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. (Chemical Entities of Biological Interest Ontology, CHEBI_63618)
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Genes

24 genes co-occuring with the biological term pravastatin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADIPOQ adiponectin, C1Q and collagen domain containing
APOA1 apolipoprotein A-I
APOE apolipoprotein E
CD14 CD14 molecule
CRP C-reactive protein, pentraxin-related
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
KIF6 kinesin family member 6
LPA lipoprotein, Lp(a)
MBL2 mannose-binding lectin (protein C) 2, soluble
MTTP microsomal triglyceride transfer protein
PPARG peroxisome proliferator-activated receptor gamma
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC22A8 solute carrier family 22 (organic anion transporter), member 8
SLCO1B1 solute carrier organic anion transporter family, member 1B1
TAS2R50 taste receptor, type 2, member 50
TLR4 toll-like receptor 4
TNF tumor necrosis factor
VAMP8 vesicle-associated membrane protein 8