| Dataset | Guide to Pharmacology Chemical Ligands of Receptors |
| Category | physical interactions |
| Type | ligand (chemical) |
| Description | A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. (Chemical Entities of Biological Interest Ontology, CHEBI_63618) |
| External Link | http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2953 |
| Similar Terms | |
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2 receptors of the pravastatin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.
