praziquantel-5874 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the praziquantel-5874 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARHGAP22 Rho GTPase activating protein 22
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMC4 armadillo repeat containing 4
ASIC3 acid sensing (proton gated) ion channel 3
ATAD5 ATPase family, AAA domain containing 5
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCDC85C coiled-coil domain containing 85C
CCL22 chemokine (C-C motif) ligand 22
CD6 CD6 molecule
CHI3L2 chitinase 3-like 2
CLCN4 chloride channel, voltage-sensitive 4
CLEC16A C-type lectin domain family 16, member A
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COL11A2 collagen, type XI, alpha 2
COL5A1 collagen, type V, alpha 1
CPNE7 copine VII
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DENND2D DENN/MADD domain containing 2D
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EFNB1 ephrin-B1
EHD1 EH-domain containing 1
ELAC2 elaC ribonuclease Z 2
EPAS1 endothelial PAS domain protein 1
ERC2-IT1 ERC2 intronic transcript 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF12 fibroblast growth factor 12
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GEMIN8 gem (nuclear organelle) associated protein 8
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INO80B INO80 complex subunit B
INS insulin
IPO8 importin 8
IRGQ immunity-related GTPase family, Q
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KCTD17 potassium channel tetramerization domain containing 17
KRT34 keratin 34, type I
KRTAP9-9 keratin associated protein 9-9
KYNU kynureninase
LAMB4 laminin, beta 4
LAMP1 lysosomal-associated membrane protein 1
LOC729164 hCG1732469
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP2K2 mitogen-activated protein kinase kinase 2
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP10 matrix metallopeptidase 10
MST1 macrophage stimulating 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEK11 NIMA-related kinase 11
NOX1 NADPH oxidase 1
OSBPL10 oxysterol binding protein-like 10
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARP6 poly (ADP-ribose) polymerase family, member 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PER1 period circadian clock 1
PLCH1 phospholipase C, eta 1
PLP1 proteolipid protein 1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POLL polymerase (DNA directed), lambda
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
SIX3 SIX homeobox 3
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SQSTM1 sequestosome 1
STS steroid sulfatase (microsomal), isozyme S
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAS2R10 taste receptor, type 2, member 10
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEAD3 TEA domain family member 3
TLE2 transducin-like enhancer of split 2
TLE6 transducin-like enhancer of split 6
TMEM19 transmembrane protein 19
TOP3A topoisomerase (DNA) III alpha
TPP1 tripeptidyl peptidase I
TTLL1 tubulin tyrosine ligase-like family member 1
UBXN1 UBX domain protein 1
USB1 U6 snRNA biogenesis 1
WDTC1 WD and tetratricopeptide repeats 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZER1 zyg-11 related, cell cycle regulator
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF318 zinc finger protein 318
ZNF606 zinc finger protein 606
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
AFAP1 actin filament associated protein 1
APOLD1 apolipoprotein L domain containing 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARID4A AT rich interactive domain 4A (RBP1-like)
ARL14 ADP-ribosylation factor-like 14
ASB8 ankyrin repeat and SOCS box containing 8
ATP7B ATPase, Cu++ transporting, beta polypeptide
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCAS4 breast carcinoma amplified sequence 4
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BRWD1 bromodomain and WD repeat domain containing 1
C11ORF30 chromosome 11 open reading frame 30
C11ORF73 chromosome 11 open reading frame 73
C1ORF159 chromosome 1 open reading frame 159
C21ORF91 chromosome 21 open reading frame 91
CAPN15 calpain 15
CCDC94 coiled-coil domain containing 94
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPT centromere protein T
CFAP69 cilia and flagella associated protein 69
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYB5R4 cytochrome b5 reductase 4
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
ECM1 extracellular matrix protein 1
EGF epidermal growth factor
EGLN2 egl-9 family hypoxia-inducible factor 2
GBX2 gastrulation brain homeobox 2
GLCE glucuronic acid epimerase
GLT8D2 glycosyltransferase 8 domain containing 2
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HMG20A high mobility group 20A
HOXC10 homeobox C10
IFNA14 interferon, alpha 14
KIAA0894 KIAA0894 protein
KIAA0895 KIAA0895
KIF13B kinesin family member 13B
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEF1 melanoma antigen family F1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK3 mitogen-activated protein kinase 3
MFSD10 major facilitator superfamily domain containing 10
MFSD11 major facilitator superfamily domain containing 11
MITF microphthalmia-associated transcription factor
MYLK myosin light chain kinase
NDP Norrie disease (pseudoglioma)
NPDC1 neural proliferation, differentiation and control, 1
NPFFR1 neuropeptide FF receptor 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NUP62CL nucleoporin 62kDa C-terminal like
NXPE3 neurexophilin and PC-esterase domain family, member 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OTUD3 OTU deubiquitinase 3
P3H1 prolyl 3-hydroxylase 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAQR6 progestin and adipoQ receptor family member VI
PCBP4 poly(rC) binding protein 4
PEX13 peroxisomal biogenesis factor 13
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHC1 polyhomeotic homolog 1 (Drosophila)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PID1 phosphotyrosine interaction domain containing 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLIN3 perilipin 3
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAI2 retinoic acid induced 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL10L ribosomal protein L10-like
RUSC2 RUN and SH3 domain containing 2
SCAMP5 secretory carrier membrane protein 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
TEX40 testis expressed 40
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLN1 talin 1
TMEM2 transmembrane protein 2
TMEM209 transmembrane protein 209
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPYL2 TSPY-like 2
TTC26 tetratricopeptide repeat domain 26
TUBA3D tubulin, alpha 3d
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBXN6 UBX domain protein 6
USP27X ubiquitin specific peptidase 27, X-linked
WDR37 WD repeat domain 37
ZBTB48 zinc finger and BTB domain containing 48
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF254 zinc finger protein 254
ZNF324 zinc finger protein 324
ZNF804A zinc finger protein 804A
ZNF862 zinc finger protein 862