protein regulator of cytokinesis 1|This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 9055)
Similar Terms
Downloads & Tools
Genes
14 genes co-occuring with the biological term prc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
