predominant Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

361 genes co-occuring with the biological term predominant in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
ACTB actin, beta
ACTG1 actin gamma 1
ACTR6 ARP6 actin-related protein 6 homolog (yeast)
ACVRL1 activin A receptor type II-like 1
ADAM10 ADAM metallopeptidase domain 10
ADCY3 adenylate cyclase 3
ADCY6 adenylate cyclase 6
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADRA1B adrenoceptor alpha 1B
ADRB3 adrenoceptor beta 3
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOA1 apolipoprotein A-I
APOC3 apolipoprotein C-III
APP amyloid beta (A4) precursor protein
ARG2 arginase 2
ARHGAP26 Rho GTPase activating protein 26
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARID1A AT rich interactive domain 1A (SWI-like)
ATM ATM serine/threonine kinase
ATXN3 ataxin 3
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BICD2 bicaudal D homolog 2 (Drosophila)
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C2 complement component 2
C9ORF72 chromosome 9 open reading frame 72
CA7 carbonic anhydrase VII
CADM1 cell adhesion molecule 1
CANT1 calcium activated nucleotidase 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBX5 chromobox homolog 5
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD163 CD163 molecule
CD19 CD19 molecule
CD1A CD1a molecule
CD209 CD209 molecule
CD247 CD247 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD80 CD80 molecule
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CFB complement factor B
CHEK1 checkpoint kinase 1
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHGA chromogranin A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP2B charged multivesicular body protein 2B
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLN3 ceroid-lipofuscinosis, neuronal 3
CLU clusterin
CNGB3 cyclic nucleotide gated channel beta 3
COMT catechol-O-methyltransferase
CREB3L1 cAMP responsive element binding protein 3-like 1
CRP C-reactive protein, pentraxin-related
CTSW cathepsin W
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2A cytochrome P450, family 2, subfamily A
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCLRE1C DNA cross-link repair 1C
DDB1 damage-specific DNA binding protein 1, 127kDa
DES desmin
DISC1 disrupted in schizophrenia 1
DNASE2B deoxyribonuclease II beta
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EDN1 endothelin 1
EFHD2 EF-hand domain family, member D2
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
ELF2 E74-like factor 2 (ets domain transcription factor)
ENG endoglin
EP300 E1A binding protein p300
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETV4 ets variant 4
EWSR1 EWS RNA-binding protein 1
F10 coagulation factor X
F11 coagulation factor XI
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FANCC Fanconi anemia, complementation group C
FBN1 fibrillin 1
FHL1 four and a half LIM domains 1
FLG filaggrin
FLOT1 flotillin 1
FLOT2 flotillin 2
FNBP1L formin binding protein 1-like
FOXG1 forkhead box G1
FOXO3 forkhead box O3
FPR1 formyl peptide receptor 1
FTO fat mass and obesity associated
FUS FUS RNA binding protein
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
G6PD glucose-6-phosphate dehydrogenase
GATA3 GATA binding protein 3
GJB2 gap junction protein, beta 2, 26kDa
GLI2 GLI family zinc finger 2
GLRX3 glutaredoxin 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GRHL3 grainyhead-like 3 (Drosophila)
GRK6 G protein-coupled receptor kinase 6
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
H2AFX H2A histone family, member X
HAPLN2 hyaluronan and proteoglycan link protein 2
HAPLN4 hyaluronan and proteoglycan link protein 4
HAS1 hyaluronan synthase 1
HAVCR2 hepatitis A virus cellular receptor 2
HBD hemoglobin, delta
HDAC8 histone deacetylase 8
HFE2 hemochromatosis type 2 (juvenile)
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNF1A HNF1 homeobox A
HP haptoglobin
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB1 heat shock 27kDa protein 1
HTT huntingtin
ICOS inducible T-cell co-stimulator
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL18 interleukin 18
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL32 interleukin 32
IL33 interleukin 33
IL4 interleukin 4
IL6 interleukin 6
INS insulin
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA8 integrin, alpha 8
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK2 Janus kinase 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA5 laminin, alpha 5
LCN6 lipocalin 6
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPG lipase, endothelial
LITAF lipopolysaccharide-induced TNF factor
LPAR2 lysophosphatidic acid receptor 2
LPAR6 lysophosphatidic acid receptor 6
LRP1 low density lipoprotein receptor-related protein 1
LRP6 low density lipoprotein receptor-related protein 6
LRRK2 leucine-rich repeat kinase 2
LTC4S leukotriene C4 synthase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MECP2 methyl CpG binding protein 2
MIR122 microRNA 122
MIR21 microRNA 21
MITF microphthalmia-associated transcription factor
MLH1 mutL homolog 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPDZ multiple PDZ domain protein
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTAP methylthioadenosine phosphorylase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUM1 melanoma associated antigen (mutated) 1
MUTYH mutY homolog
MYBPC3 myosin binding protein C, cardiac
NCF1 neutrophil cytosolic factor 1
NELFE negative elongation factor complex member E
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP1 NLR family, pyrin domain containing 1
NPAT nuclear protein, ataxia-telangiectasia locus
NPTN neuroplastin
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR5A1 nuclear receptor subfamily 5, group A, member 1
NXPH1 neurexophilin 1
OLIG2 oligodendrocyte lineage transcription factor 2
ORAI1 ORAI calcium release-activated calcium modulator 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAX2 paired box 2
PAX5 paired box 5
PDCD1 programmed cell death 1
PDE4B phosphodiesterase 4B, cAMP-specific
PGR progesterone receptor
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGR polymeric immunoglobulin receptor
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKP2 plakophilin 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PNPLA3 patatin-like phospholipase domain containing 3
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PPARD peroxisome proliferator-activated receptor delta
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRDM9 PR domain containing 9
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PROS1 protein S (alpha)
PRRT2 proline-rich transmembrane protein 2
PRSS1 protease, serine, 1 (trypsin 1)
PSEN1 presenilin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAB11B RAB11B, member RAS oncogene family
RAB37 RAB37, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALBP1 ralA binding protein 1
RECQL RecQ helicase-like
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RET ret proto-oncogene
RHOA ras homolog family member A
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RS1 retinoschisin 1
RUNX3 runt-related transcription factor 3
SAA1 serum amyloid A1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SDC4 syndecan 4
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SELE selectin E
SELL selectin L
SEMG1 semenogelin I
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SHH sonic hedgehog
SIRT1 sirtuin 1
SIX1 SIX homeobox 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC41A1 solute carrier family 41 (magnesium transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SORT1 sortilin 1
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSTR2 somatostatin receptor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP5L syntaxin binding protein 5-like
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFE3 transcription factor binding to IGHM enhancer 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TH tyrosine hydroxylase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLN2 talin 2
TLR2 toll-like receptor 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TTF1 transcription termination factor, RNA polymerase I
UCN urocortin
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VASP vasodilator-stimulated phosphoprotein
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VIPR1 vasoactive intestinal peptide receptor 1
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)