primaquine-3279 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the primaquine-3279 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AEN apoptosis enhancing nuclease
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMPD3 adenosine monophosphate deaminase 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
BLZF1 basic leucine zipper nuclear factor 1
C1ORF54 chromosome 1 open reading frame 54
CCDC64 coiled-coil domain containing 64
CCDC85C coiled-coil domain containing 85C
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDR2L cerebellar degeneration-related protein 2-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DMWD dystrophia myotonica, WD repeat containing
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMBP dynamin binding protein
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EDN1 endothelin 1
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAS Fas cell surface death receptor
FH fumarate hydratase
FHL1 four and a half LIM domains 1
FKBP10 FK506 binding protein 10, 65 kDa
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45G growth arrest and DNA-damage-inducible, gamma
H1FX H1 histone family, member X
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL5RA interleukin 5 receptor, alpha
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LIF leukemia inhibitory factor
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MTA1 metastasis associated 1
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NACA nascent polypeptide-associated complex alpha subunit
NCF4 neutrophil cytosolic factor 4, 40kDa
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPM3 nucleophosmin/nucleoplasmin 3
OSGIN1 oxidative stress induced growth inhibitor 1
PBX2 pre-B-cell leukemia homeobox 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAU plasminogen activator, urokinase
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
RGS20 regulator of G-protein signaling 20
RND1 Rho family GTPase 1
RPL5 ribosomal protein L5
RPS4Y1 ribosomal protein S4, Y-linked 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SIRT6 sirtuin 6
SLC35E2 solute carrier family 35, member E2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRSF7 serine/arginine-rich splicing factor 7
SSBP1 single-stranded DNA binding protein 1, mitochondrial
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCP10 t-complex 10
TGFB2 transforming growth factor, beta 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VIPR1 vasoactive intestinal peptide receptor 1
VIPR2 vasoactive intestinal peptide receptor 2
VLDLR very low density lipoprotein receptor
ZYX zyxin

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD36B ankyrin repeat domain 36B
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASAP1-IT1 ASAP1 intronic transcript 1
ASB8 ankyrin repeat and SOCS box containing 8
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP11B ATPase, class VI, type 11B
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCORL1 BCL6 corepressor-like 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BMP4 bone morphogenetic protein 4
C17ORF80 chromosome 17 open reading frame 80
C1ORF56 chromosome 1 open reading frame 56
C2ORF68 chromosome 2 open reading frame 68
CASD1 CAS1 domain containing 1
CCDC15 coiled-coil domain containing 15
CCDC6 coiled-coil domain containing 6
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CENPJ centromere protein J
CHRM3 cholinergic receptor, muscarinic 3
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CRYBG3 beta-gamma crystallin domain containing 3
DCAF16 DDB1 and CUL4 associated factor 16
DENND4C DENN/MADD domain containing 4C
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EML4 echinoderm microtubule associated protein like 4
EXOC5 exocyst complex component 5
FBXW12 F-box and WD repeat domain containing 12
FZD3 frizzled class receptor 3
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GHR growth hormone receptor
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPR19 G protein-coupled receptor 19
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
HELLS helicase, lymphoid-specific
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BG histone cluster 1, H2bg
HIST1H4F histone cluster 1, H4f
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL4R interleukin 4 receptor
INCENP inner centromere protein antigens 135/155kDa
IPP intracisternal A particle-promoted polypeptide
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KDM5C lysine (K)-specific demethylase 5C
LIN37 lin-37 DREAM MuvB core complex component
LOC100287590 uncharacterized LOC100287590
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC730101 uncharacterized LOC730101
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED18 mediator complex subunit 18
METTL16 methyltransferase like 16
MGC12488
MPHOSPH8 M-phase phosphoprotein 8
MTMR11 myotubularin related protein 11
MTRF1 mitochondrial translational release factor 1
NAIP NLR family, apoptosis inhibitory protein
NPY1R neuropeptide Y receptor Y1
PCF11 PCF11 cleavage and polyadenylation factor subunit
RGS17 regulator of G-protein signaling 17
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNFT1 ring finger protein, transmembrane 1
RPL13P5 ribosomal protein L13 pseudogene 5
RWDD2A RWD domain containing 2A
SCAI suppressor of cancer cell invasion
SERTAD3 SERTA domain containing 3
SIX1 SIX homeobox 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TDRD1 tudor domain containing 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIPRL TOR signaling pathway regulator
TPCN1 two pore segment channel 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
VASH2 vasohibin 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF160 zinc finger protein 160
ZNF430 zinc finger protein 430
ZNF587 zinc finger protein 587
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721