principal Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

171 genes co-occuring with the biological term principal in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AGER advanced glycosylation end product-specific receptor
AIRE autoimmune regulator
AK1 adenylate kinase 1
ALB albumin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOA1 apolipoprotein A-I
APP amyloid beta (A4) precursor protein
AQP2 aquaporin 2 (collecting duct)
ARMS2 age-related maculopathy susceptibility 2
ATN1 atrophin 1
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BDNF brain-derived neurotrophic factor
BLVRA biliverdin reductase A
BMP2 bone morphogenetic protein 2
BMP3 bone morphogenetic protein 3
BRD4 bromodomain containing 4
C8A complement component 8, alpha polypeptide
C8B complement component 8, beta polypeptide
C8G complement component 8, gamma polypeptide
C9 complement component 9
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CALR calreticulin
CATSPER1 cation channel, sperm associated 1
CCAR2 cell cycle and apoptosis regulator 2
CCR2 chemokine (C-C motif) receptor 2
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFH complement factor H
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS1BP7 CDC28 protein kinase regulatory subunit 1B pseudogene 7
CLEC9A C-type lectin domain family 9, member A
COL1A2 collagen, type I, alpha 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRYGB crystallin, gamma B
CRYGC crystallin, gamma C
CRYGD crystallin, gamma D
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNBIP1 catenin, beta interacting protein 1
CTSG cathepsin G
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYSLTR1 cysteinyl leukotriene receptor 1
DCLRE1C DNA cross-link repair 1C
EGLN2 egl-9 family hypoxia-inducible factor 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EP300 E1A binding protein p300
ESR2 estrogen receptor 2 (ER beta)
ESRRB estrogen-related receptor beta
ETV5 ets variant 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT3LG fms-related tyrosine kinase 3 ligand
FOXP3 forkhead box P3
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GJA3 gap junction protein, alpha 3, 46kDa
GJB2 gap junction protein, beta 2, 26kDa
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAT3 guanine nucleotide binding protein, alpha transducing 3
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRN granulin
GYPC glycophorin C (Gerbich blood group)
HAS2 hyaluronan synthase 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HNF1B HNF1 homeobox B
HTN3 histatin 3
IGL immunoglobulin lambda locus
IL10 interleukin 10
IL12A interleukin 12A
IL1RN interleukin 1 receptor antagonist
INADL InaD-like (Drosophila)
JAK2 Janus kinase 2
JUNB jun B proto-oncogene
KARS lysyl-tRNA synthetase
KAT2B K(lysine) acetyltransferase 2B
KCNIP1 Kv channel interacting protein 1
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
LCN1 lipocalin 1
LEP leptin
LGI4 leucine-rich repeat LGI family, member 4
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LNX2 ligand of numb-protein X 2
LUZP4 leucine zipper protein 4
LY96 lymphocyte antigen 96
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAPK3 mitogen-activated protein kinase 3
MCOLN1 mucolipin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MICU1 mitochondrial calcium uptake 1
MMP1 matrix metallopeptidase 1
MPDZ multiple PDZ domain protein
MSI1 musashi RNA-binding protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH1 notch 1
NUTM1 NUT midline carcinoma, family member 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PAX3 paired box 3
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA2 protein disulfide isomerase family A, member 2
PICK1 protein interacting with PRKCA 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIKFYVE phosphoinositide kinase, FYVE finger containing
POLG polymerase (DNA directed), gamma
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRIMA1 proline rich membrane anchor 1
PRKG2 protein kinase, cGMP-dependent, type II
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXN paxillin
QKI QKI, KH domain containing, RNA binding
RASGEF1B RasGEF domain family, member 1B
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBP4 retinol binding protein 4, plasma
RETN resistin
ROMO1 reactive oxygen species modulator 1
ROPN1 rhophilin associated tail protein 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RUNX3 runt-related transcription factor 3
RXRA retinoid X receptor, alpha
RYR1 ryanodine receptor 1 (skeletal)
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMN2 survival of motor neuron 2, centromeric
SOD1 superoxide dismutase 1, soluble
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBX19 T-box 19
TEC tec protein tyrosine kinase
TEKT1 tektin 1
TGFB1 transforming growth factor, beta 1
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TNF tumor necrosis factor
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNXB tenascin XB
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TREX1 three prime repair exonuclease 1
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TSG101 tumor susceptibility 101
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
VEGFA vascular endothelial growth factor A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase