prion disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83) (Experimental Factor Ontology, EFO_0004720)
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Genes

259 genes co-occuring with the disease prion disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PRNP prion protein 5.16356
MSMB microseminoprotein, beta- 2.03876
SCN2A sodium channel, voltage gated, type II alpha subunit 1.92858
PRND prion protein 2 (dublet) 1.88021
SCRG1 stimulator of chondrogenesis 1 1.5476
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 1.45924
LARS leucyl-tRNA synthetase 1.42805
RPSA ribosomal protein SA 1.36771
TXNDC9 thioredoxin domain containing 9 1.28348
PNMA2 paraneoplastic Ma antigen 2 1.22909
HSPA13 heat shock protein 70kDa family, member 13 1.17507
SERF1A small EDRK-rich factor 1A (telomeric) 1.13755
SERF1B small EDRK-rich factor 1B (centromeric) 1.13755
STMN2 stathmin 2 1.07614
ZBTB38 zinc finger and BTB domain containing 38 1.06144
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 1.05513
SSBP1 single-stranded DNA binding protein 1, mitochondrial 1.05177
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 1.03914
CPNE8 copine VIII 0.995283
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.992752
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.98011
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.952021
GFAP glial fibrillary acidic protein 0.937874
CELF6 CUGBP, Elav-like family member 6 0.926279
RABEPK Rab9 effector protein with kelch motifs 0.921736
RASA2 RAS p21 protein activator 2 0.902389
ENO2 enolase 2 (gamma, neuronal) 0.900746
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 0.894179
MRC2 mannose receptor, C type 2 0.888029
ATRN attractin 0.853631
OPRD1 opioid receptor, delta 1 0.842163
MAPT microtubule-associated protein tau 0.819616
AHSP alpha hemoglobin stabilizing protein 0.808949
PADI2 peptidyl arginine deiminase, type II 0.77207
PRNT prion protein (testis specific) 0.763494
PVALB parvalbumin 0.757786
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 0.753713
FYN FYN proto-oncogene, Src family tyrosine kinase 0.752085
SDSL serine dehydratase-like 0.750864
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.739488
HTT huntingtin 0.737054
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.736243
SOD2 superoxide dismutase 2, mitochondrial 0.724502
PRH2 proline-rich protein HaeIII subfamily 2 0.684692
NGF nerve growth factor (beta polypeptide) 0.674713
SYP synaptophysin 0.662387
CHAT choline O-acetyltransferase 0.654858
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.654067
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.648138
C21ORF91 chromosome 21 open reading frame 91 0.641827
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.638282
IGHV3-30 immunoglobulin heavy variable 3-30 0.631991
RARB retinoic acid receptor, beta 0.625319
TTR transthyretin 0.612011
MAP2 microtubule-associated protein 2 0.592895
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.58939
GPC1 glypican 1 0.587444
BAX BCL2-associated X protein 0.585108
MAPRE3 microtubule-associated protein, RP/EB family, member 3 0.582384
PRH1 proline-rich protein HaeIII subfamily 1 0.577716
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.568775
MTMR7 myotubularin related protein 7 0.564889
SYT5 synaptotagmin V 0.554015
APOE apolipoprotein E 0.547807
YIPF1 Yip1 domain family, member 1 0.545868
ADAM10 ADAM metallopeptidase domain 10 0.544318
LARGE like-glycosyltransferase 0.537731
HSF4 heat shock transcription factor 4 0.534635
APP amyloid beta (A4) precursor protein 0.526518
NEFH neurofilament, heavy polypeptide 0.524974
ALB albumin 0.51611
FLOT1 flotillin 1 0.51534
SP8 Sp8 transcription factor 0.509192
FTH1 ferritin, heavy polypeptide 1 0.507657
FTL ferritin, light polypeptide 0.507657
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.502675
CAPN6 calpain 6 0.492359
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.481325
MRPL13 mitochondrial ribosomal protein L13 0.477151
GLG1 golgi glycoprotein 1 0.461261
ATG5 autophagy related 5 0.460129
TRIM15 tripartite motif containing 15 0.457864
TRIM10 tripartite motif containing 10 0.450701
MAP4 microtubule-associated protein 4 0.448064
CALB1 calbindin 1, 28kDa 0.446558
HSPA4 heat shock 70kDa protein 4 0.443923
OAZ2 ornithine decarboxylase antizyme 2 0.443171
CTSS cathepsin S 0.441666
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.43941
C8A complement component 8, alpha polypeptide 0.42364
MT-ATP8 ATP synthase F0 subunit 8 0.415024
TRIM26 tripartite motif containing 26 0.414276
IL1B interleukin 1, beta 0.408292
CLU clusterin 0.407172
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.391141
CTSD cathepsin D 0.383337
CST3 cystatin C 0.38111
HSPA8 heat shock 70kDa protein 8 0.380368
NES nestin 0.376661
CA10 carbonic anhydrase X 0.37629
PRDX6 peroxiredoxin 6 0.37629
HSF1 heat shock transcription factor 1 0.372587
ZFX zinc finger protein, X-linked 0.363347
GLUL glutamate-ammonia ligase 0.363347
MT2A metallothionein 2A 0.355235
ZFY zinc finger protein, Y-linked 0.335778
TOM1 target of myb1 (chicken) 0.333949
PARK2 parkin RBR E3 ubiquitin protein ligase 0.333218
SDC2 syndecan 2 0.328105
CA14 carbonic anhydrase XIV 0.324823
MYRF myelin regulatory factor 0.314278
PLG plasminogen 0.300533
FPR3 formyl peptide receptor 3 0.294413
NBPF10 neuroblastoma breakpoint family, member 10 0.293334
F8 coagulation factor VIII, procoagulant component 0.292257
HYOU1 hypoxia up-regulated 1 0.290462
H1F0 H1 histone family, member 0 0.289386
GUSB glucuronidase, beta 0.287593
GSN gelsolin 0.281153
AIF1 allograft inflammatory factor 1 0.279367
MARK4 MAP/microtubule affinity-regulating kinase 4 0.279011
DERA deoxyribose-phosphate aldolase (putative) 0.27687
SDPR serum deprivation response 0.275445
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.270819
GRM1 glutamate receptor, metabotropic 1 0.26514
DPYSL2 dihydropyrimidinase-like 2 0.264785
CTSC cathepsin C 0.264431
TSG101 tumor susceptibility 101 0.263368
PSEN1 presenilin 1 0.261599
LAMB1 laminin, beta 1 0.260538
C1QC complement component 1, q subcomponent, C chain 0.25877
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.258064
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.256652
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.255241
ATN1 atrophin 1 0.253831
CRYAB crystallin, alpha B 0.253127
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.252422
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.25207
PID1 phosphotyrosine interaction domain containing 1 0.249257
TSPO translocator protein (18kDa) 0.248905
AQP1 aquaporin 1 (Colton blood group) 0.248554
GFI1 growth factor independent 1 transcription repressor 0.243645
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.238752
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.235268
TF transferrin 0.234573
NPY2R neuropeptide Y receptor Y2 0.230409
IPP intracisternal A particle-promoted polypeptide 0.228679
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.223509
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.217693
PSEN2 presenilin 2 0.217012
SNAP23 synaptosomal-associated protein, 23kDa 0.207912
FPR2 formyl peptide receptor 2 0.205916
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.204263
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.203933
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.203275
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.199033
CNTF ciliary neurotrophic factor 0.195501
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.195501
MYO15A myosin XVA 0.193285
ITM2B integral membrane protein 2B 0.189859
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.187719
CHN1 chimerin 1 0.18651
CXCL13 chemokine (C-X-C motif) ligand 13 0.181798
PLK3 polo-like kinase 3 0.180937
RTN3 reticulon 3 0.180367
GDI1 GDP dissociation inhibitor 1 0.177576
HCRT hypocretin (orexin) neuropeptide precursor 0.177029
PEA15 phosphoprotein enriched in astrocytes 15 0.176485
TPH1 tryptophan hydroxylase 1 0.175411
PLS1 plastin 1 0.173571
SYN1 synapsin I 0.170789
ADAM17 ADAM metallopeptidase domain 17 0.170054
CHN2 chimerin 2 0.168148
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.167682
FEN1 flap structure-specific endonuclease 1 0.166995
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.166544
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.165655
B2M beta-2-microglobulin 0.163729
STX1B syntaxin 1B 0.162306
PRAC1 prostate cancer susceptibility candidate 1 0.161912
CPLX2 complexin 2 0.160948
MGAT4C MGAT4 family, member C 0.160387
ASPA aspartoacylase 0.157929
MCM8 minichromosome maintenance complex component 8 0.143996
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.14311
TST thiosulfate sulfurtransferase (rhodanese) 0.141166
NPAS2 neuronal PAS domain protein 2 0.136384
MRC1 mannose receptor, C type 1 0.135121
COPS2 COP9 signalosome subunit 2 0.132786
PARVA parvin, alpha 0.132141
HM13 histocompatibility (minor) 13 0.130811
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.130402
GPX2 glutathione peroxidase 2 0.129243
ANGPT1 angiopoietin 1 0.128715
TYROBP TYRO protein tyrosine kinase binding protein 0.12779
HCK HCK proto-oncogene, Src family tyrosine kinase 0.127389
PER2 period circadian clock 2 0.126564
AHCY adenosylhomocysteinase 0.126364
PRODH proline dehydrogenase (oxidase) 1 0.126245
DSE dermatan sulfate epimerase 0.125831
SP9 Sp9 transcription factor 0.125511
NMT1 N-myristoyltransferase 1 0.123549
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.123203
NDP Norrie disease (pseudoglioma) 0.122826
CRLF1 cytokine receptor-like factor 1 0.122594
IL1R1 interleukin 1 receptor, type I 0.122225
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.121806
CLDN11 claudin 11 0.120962
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.120869
LALBA lactalbumin, alpha- 0.120799
SNAP25 synaptosomal-associated protein, 25kDa 0.120611
NTF4 neurotrophin 4 0.120587
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.119761
CRYAA crystallin, alpha A 0.118801
HES4 hes family bHLH transcription factor 4 0.11875
PLP1 proteolipid protein 1 0.117552
NCF4 neutrophil cytosolic factor 4, 40kDa 0.116352
RAB3A RAB3A, member RAS oncogene family 0.115537
PER3 period circadian clock 3 0.114263
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.112475
INVS inversin 0.111608
MX2 MX dynamin-like GTPase 2 0.110996
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.110857
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.108345
GH1 growth hormone 1 0.107974
HSPH1 heat shock 105kDa/110kDa protein 1 0.107367
VSNL1 visinin-like 1 0.10714
PRPF3 pre-mRNA processing factor 3 0.10714
CNTFR ciliary neurotrophic factor receptor 0.106871
APOC1 apolipoprotein C-I 0.106832
CNTN3 contactin 3 (plasmacytoma associated) 0.106286
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.105816
CHD4 chromodomain helicase DNA binding protein 4 0.105176
THY1 Thy-1 cell surface antigen 0.104735
TPPP tubulin polymerization promoting protein 0.104448
IL1A interleukin 1, alpha 0.104407
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.104366
GANC glucosidase, alpha; neutral C 0.103955
OAZ1 ornithine decarboxylase antizyme 1 0.103332
FLOT2 flotillin 2 0.10308
TLR9 toll-like receptor 9 0.102702
S100B S100 calcium binding protein B 0.102618
CSN3 casein kappa 0.102061
PLD1 phospholipase D1, phosphatidylcholine-specific 0.101888
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.101888
SP6 Sp6 transcription factor 0.101198
ERAS ES cell expressed Ras 0.100006
DCN decorin 0.099826
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.099781
C1QB complement component 1, q subcomponent, B chain 0.0996
HMOX1 heme oxygenase 1 0.098189
APCS amyloid P component, serum 0.098097
ENGASE endo-beta-N-acetylglucosaminidase 0.097958
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 0.097866
CREB1 cAMP responsive element binding protein 1 0.097682
BCHE butyrylcholinesterase 0.096556
SP7 Sp7 transcription factor 0.096035
LTB lymphotoxin beta (TNF superfamily, member 3) 0.095842
LTA lymphotoxin alpha 0.09541