proadifen-2707 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the proadifen-2707 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ADGRL1 adhesion G protein-coupled receptor L1
ADRA1A adrenoceptor alpha 1A
ADRB3 adrenoceptor beta 3
AGXT alanine-glyoxylate aminotransferase
AIM1L absent in melanoma 1-like
AREG amphiregulin
ARMC4 armadillo repeat containing 4
BIN1 bridging integrator 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1QL1 complement component 1, q subcomponent-like 1
C21ORF2 chromosome 21 open reading frame 2
CA5B carbonic anhydrase VB, mitochondrial
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CD80 CD80 molecule
CDC14A cell division cycle 14A
CEP41 centrosomal protein 41kDa
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC3B C-type lectin domain family 3, member B
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL1A1 collagen, type I, alpha 1
CRAT carnitine O-acetyltransferase
CREB3L1 cAMP responsive element binding protein 3-like 1
CREM cAMP responsive element modulator
CTGF connective tissue growth factor
CYLD cylindromatosis (turban tumor syndrome)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHRS9 dehydrogenase/reductase (SDR family) member 9
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLX2 distal-less homeobox 2
DNAH7 dynein, axonemal, heavy chain 7
DNASE2 deoxyribonuclease II, lysosomal
DNMBP dynamin binding protein
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ESR1 estrogen receptor 1
FBRS fibrosin
FGFR1 fibroblast growth factor receptor 1
FOXA1 forkhead box A1
G0S2 G0/G1 switch 2
GATA2 GATA binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GPR25 G protein-coupled receptor 25
HES1 hes family bHLH transcription factor 1
HIST1H2AJ histone cluster 1, H2aj
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXC10 homeobox C10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IGLV1-44 immunoglobulin lambda variable 1-44
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KDR kinase insert domain receptor
KIAA1654 KIAA1654 protein
KIDINS220 kinase D-interacting substrate, 220kDa
KLK14 kallikrein-related peptidase 14
KRT17 keratin 17, type I
LRRC31 leucine rich repeat containing 31
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MEFV Mediterranean fever
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MUC1 mucin 1, cell surface associated
MYH14 myosin, heavy chain 14, non-muscle
NF1 neurofibromin 1
NPTX2 neuronal pentraxin II
NR3C2 nuclear receptor subfamily 3, group C, member 2
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PCDH17 protocadherin 17
PER3 period circadian clock 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCE protein kinase C, epsilon
PRLH prolactin releasing hormone
PRR5 proline rich 5 (renal)
PTCH2 patched 2
PTPRF protein tyrosine phosphatase, receptor type, F
PVR poliovirus receptor
QSER1 glutamine and serine rich 1
RIMS2 regulating synaptic membrane exocytosis 2
RNF208 ring finger protein 208
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH2D3A SH2 domain containing 3A
SIRT4 sirtuin 4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SMIM14 small integral membrane protein 14
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSTR4 somatostatin receptor 4
SSTR5 somatostatin receptor 5
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STK17A serine/threonine kinase 17a
TEX40 testis expressed 40
TGFBR3 transforming growth factor, beta receptor III
TIMP3 TIMP metallopeptidase inhibitor 3
TSC22D2 TSC22 domain family, member 2
ULBP2 UL16 binding protein 2
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACAD10 acyl-CoA dehydrogenase family, member 10
ACOX2 acyl-CoA oxidase 2, branched chain
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARL15 ADP-ribosylation factor-like 15
ARMCX4 armadillo repeat containing, X-linked 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
B3GNT1
BNC2 basonuclin 2
C14ORF93 chromosome 14 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
C19ORF40 chromosome 19 open reading frame 40
CCDC85C coiled-coil domain containing 85C
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CKB creatine kinase, brain
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYGC crystallin, gamma C
CTSV cathepsin V
DPYS dihydropyrimidinase
DSPP dentin sialophosphoprotein
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELP6 elongator acetyltransferase complex subunit 6
FAM127B family with sequence similarity 127, member B
FGGY FGGY carbohydrate kinase domain containing
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GSTT1 glutathione S-transferase theta 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H2AE histone cluster 1, H2ae
HIST1H2AI histone cluster 1, H2ai
HIST1H2AM histone cluster 1, H2am
HIST1H3B histone cluster 1, H3b
HLA-DMB major histocompatibility complex, class II, DM beta
HOXC8 homeobox C8
IFT140 intraflagellar transport 140
IFT81 intraflagellar transport 81
INCENP inner centromere protein antigens 135/155kDa
ITGB7 integrin, beta 7
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KLF3 Kruppel-like factor 3 (basic)
KLHL36 kelch-like family member 36
LHFP lipoma HMGIC fusion partner
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LY6E lymphocyte antigen 6 complex, locus E
MAB21L1 mab-21-like 1 (C. elegans)
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MEP1B meprin A, beta
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
MXD3 MAX dimerization protein 3
NAG18 NAG18 mRNA
NCALD neurocalcin delta
NCS1 neuronal calcium sensor 1
NDE1 nudE neurodevelopment protein 1
NEUROD4 neuronal differentiation 4
PADI2 peptidyl arginine deiminase, type II
PDE12 phosphodiesterase 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PHC1 polyhomeotic homolog 1 (Drosophila)
PIPOX pipecolic acid oxidase
PKD2L2 polycystic kidney disease 2-like 2
PLA2G1B phospholipase A2, group IB (pancreas)
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS53 protease, serine, 53
PTCD1 pentatricopeptide repeat domain 1
RAB13 RAB13, member RAS oncogene family
RCAN3 RCAN family member 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SCGB2A2 secretoglobin, family 2A, member 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPAG4 sperm associated antigen 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STARD13 StAR-related lipid transfer (START) domain containing 13
STBD1 starch binding domain 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBL1Y transducin (beta)-like 1, Y-linked
TMC5 transmembrane channel-like 5
TUBB2A tubulin, beta 2A class IIa
TWSG1 twisted gastrulation BMP signaling modulator 1
UNC119 unc-119 homolog (C. elegans)
VNN2 vanin 2
ZBTB25 zinc finger and BTB domain containing 25
ZNF493 zinc finger protein 493
ZNF528 zinc finger protein 528