probucol-1608 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the probucol-1608 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ACVRL1 activin A receptor type II-like 1
ADGRE5 adhesion G protein-coupled receptor E5
ADRB2 adrenoceptor beta 2, surface
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ASAP1-IT1 ASAP1 intronic transcript 1
ASCC1 activating signal cointegrator 1 complex subunit 1
C19ORF66 chromosome 19 open reading frame 66
C2CD2L C2CD2-like
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD86 CD86 molecule
CIZ1 CDKN1A interacting zinc finger protein 1
CLCN6 chloride channel, voltage-sensitive 6
CLEC7A C-type lectin domain family 7, member A
CS citrate synthase
CSNK1G2 casein kinase 1, gamma 2
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNM1 dynamin 1
DUSP2 dual specificity phosphatase 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ENO2 enolase 2 (gamma, neuronal)
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FPR1 formyl peptide receptor 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPSM3 G-protein signaling modulator 3
GRK6 G protein-coupled receptor kinase 6
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
HEXIM1 hexamethylene bis-acetamide inducible 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MLXIP MLX interacting protein
MOCS3 molybdenum cofactor synthesis 3
MOSPD2 motile sperm domain containing 2
MSH3 mutS homolog 3
MYL10 myosin, light chain 10, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NCOA3 nuclear receptor coactivator 3
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFX1 nuclear transcription factor, X-box binding 1
NINJ1 ninjurin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL2 oxysterol binding protein-like 2
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PAM peptidylglycine alpha-amidating monooxygenase
PCIF1 PDX1 C-terminal inhibiting factor 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PGLYRP4 peptidoglycan recognition protein 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB2 phospholipase C, beta 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTK2 protein tyrosine kinase 2
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAD17 RAD17 homolog (S. pombe)
RBM10 RNA binding motif protein 10
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS16 regulator of G-protein signaling 16
RIN1 Ras and Rab interactor 1
RNGTT RNA guanylyltransferase and 5'-phosphatase
SF3A2 splicing factor 3a, subunit 2, 66kDa
SIDT2 SID1 transmembrane family, member 2
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SNX11 sorting nexin 11
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPN sialophorin
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TMEM246 transmembrane protein 246
TMEM45A transmembrane protein 45A
UNC119B unc-119 homolog B (C. elegans)
USF2 upstream transcription factor 2, c-fos interacting
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZBTB48 zinc finger and BTB domain containing 48
ZNF408 zinc finger protein 408

decreased expression

Symbol Name
ACOT8 acyl-CoA thioesterase 8
ACVR2A activin A receptor, type IIA
AGO3 argonaute RISC catalytic component 3
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARHGAP10 Rho GTPase activating protein 10
ASTE1 asteroid homolog 1 (Drosophila)
ATAD3A ATPase family, AAA domain containing 3A
ATG2A autophagy related 2A
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRD9 bromodomain containing 9
C14ORF159 chromosome 14 open reading frame 159
C1GALT1C1 C1GALT1-specific chaperone 1
C9ORF40 chromosome 9 open reading frame 40
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CARD9 caspase recruitment domain family, member 9
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CD302 CD302 molecule
CDK5 cyclin-dependent kinase 5
CLTCL1 clathrin, heavy chain-like 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCLRE1A DNA cross-link repair 1A
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DGKD diacylglycerol kinase, delta 130kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EDAR ectodysplasin A receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP3 elongator acetyltransferase complex subunit 3
ERF Ets2 repressor factor
FAM173A family with sequence similarity 173, member A
FAM222B family with sequence similarity 222, member B
GEMIN6 gem (nuclear organelle) associated protein 6
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPATCH2 G patch domain containing 2
GRM6 glutamate receptor, metabotropic 6
HINFP histone H4 transcription factor
HK1 hexokinase 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL2RG interleukin 2 receptor, gamma
IPO13 importin 13
JUNB jun B proto-oncogene
LSP1 lymphocyte-specific protein 1
LUC7L LUC7-like (S. cerevisiae)
MBIP MAP3K12 binding inhibitory protein 1
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MED15 mediator complex subunit 15
MFSD5 major facilitator superfamily domain containing 5
MOGS mannosyl-oligosaccharide glucosidase
MON1B MON1 secretory trafficking family member B
MT1HL1 metallothionein 1H-like 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NUBP2 nucleotide binding protein 2
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAK1IP1 PAK1 interacting protein 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PELI1 pellino E3 ubiquitin protein ligase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITRM1 pitrilysin metallopeptidase 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNPO pyridoxamine 5'-phosphate oxidase
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRMT3 protein arginine methyltransferase 3
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSKH1 protein serine kinase H1
PTBP2 polypyrimidine tract binding protein 2
PTOV1 prostate tumor overexpressed 1
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RNF126 ring finger protein 126
RPL39L ribosomal protein L39-like
RPS14P3 ribosomal protein S14 pseudogene 3
SERTAD3 SERTA domain containing 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SPX spexin hormone
STAC SH3 and cysteine rich domain
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D31 TBC1 domain family, member 31
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM39A transmembrane protein 39A
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIM22 tripartite motif containing 22
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TTPAL tocopherol (alpha) transfer protein-like
TWF2 twinfilin actin binding protein 2
UBQLN4 ubiquilin 4
UCKL1 uridine-cytidine kinase 1-like 1
USB1 U6 snRNA biogenesis 1
WDR46 WD repeat domain 46
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF189 zinc finger protein 189
ZNF268 zinc finger protein 268
ZNF432 zinc finger protein 432
ZNF573 zinc finger protein 573